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Zorvolex
Zorvolex (diclofenac) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and manage the symptoms of osteoarthritis. It works by reducing inflammation, pain, and swelling in the body. Zorvolex is often prescribed to manage pain from various conditions, including joint pain, muscle pain, and arthritis. It is a lower-dose formulation of diclofenac, designed to reduce the risk of side effects associated with long-term NSAID use.
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Frequently Asked Questions
How long does it take for Zorvolex to work?
Zorvolex generally starts working within 1-2 hours after taking it, providing relief from mild to moderate pain.
Can I take Zorvolex with other pain relievers?
You should avoid taking Zorvolex with other NSAIDs (such as ibuprofen or naproxen). However, acetaminophen (Tylenol) may be taken with Zorvolex, but always consult your healthcare provider before combining medications.
What should I do if I miss a dose of Zorvolex?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses.
Is Zorvolex safe for long-term use?
Zorvolex can be used long-term under medical supervision, but long-term use of NSAIDs is associated with increased risks of heart attack, stroke, and gastrointestinal issues. Regular monitoring by your healthcare provider is important.
Can Zorvolex cause stomach problems?
Yes, like other NSAIDs, Zorvolex can cause stomach upset, ulcers, or gastrointestinal bleeding. It’s important to take Zorvolex with food or milk and to contact your doctor if you experience any signs of bleeding, such as black or tarry stools.
Comprehensive Drug Guide
How Does Zorvolex Work?
Zorvolex works by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins, chemicals in the body that cause inflammation and pain. By blocking this enzyme, Zorvolex reduces inflammation and provides relief from pain associated with conditions like osteoarthritis and injury-related pain.
Common Dosages
- 18 mg capsules
- 35 mg capsules
Typical Dosing
- For mild to moderate pain: The usual dose is 18 mg or 35 mg taken three times a day as needed for pain relief.
- For osteoarthritis: The recommended dose is 35 mg three times daily. The dose may be adjusted based on the patient’s needs and response to the medication.
Typical Dosing
FDA Approved Indications
- Mild to moderate pain (e.g., postoperative pain, injury-related pain)
- Osteoarthritis pain
Who Shouldn't Take Zorvolex?
- Known hypersensitivity to diclofenac or any component of the formulation
- Asthma, urticaria, or other allergic reactions triggered by NSAIDs or aspirin
- History of gastrointestinal bleeding or ulcers
- Severe kidney or liver impairment
- Coronary artery bypass graft (CABG) surgery
Advice From The Pharmacist
- Zorvolex should be taken with food or milk to help reduce the risk of stomach upset or gastrointestinal side effects.
- Avoid using other NSAIDs (such as ibuprofen or naproxen) while taking Zorvolex, as this can increase the risk of stomach ulcers and bleeding.
- Monitor for signs of gastrointestinal bleeding, such as black or tarry stools, and contact your healthcare provider immediately if these symptoms occur.
- Be cautious when taking Zorvolex if you have a history of heart disease, as NSAIDs can increase the risk of heart attack or stroke, particularly with long-term use.
Side Effects of Zorvolex
Common Side Effects
- Stomach pain or upset
- Diarrhea
- Nausea
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Gastrointestinal bleeding (black or tarry stools, vomiting blood)
- Heart attack or stroke
- Liver damage (yellowing of the skin or eyes, dark urine)
- Kidney problems (decreased urination, swelling in the legs or ankles)
- Severe allergic reactions (rash, itching, swelling, difficulty breathing)
Risks and Warnings of Zorvolex
- Cardiovascular Risk: Long-term use of NSAIDs, including Zorvolex, may increase the risk of heart attack or stroke. This risk may be higher in patients with existing heart conditions or those using the drug at higher doses.
- Gastrointestinal Risk: Zorvolex can cause serious gastrointestinal events, such as bleeding, ulceration, and perforation of the stomach or intestines. These effects can occur without warning and are more likely with long-term use or in patients with a history of ulcers.
- Liver Toxicity: Zorvolex may cause liver damage, especially in patients with pre-existing liver conditions. Periodic liver function tests may be needed during long-term use.
Interactions with Zorvolex
Common Drug Interactions
- Anticoagulants (such as warfarin): Combining Zorvolex with blood thinners can increase the risk of bleeding.
- Other NSAIDs: Taking Zorvolex with other NSAIDs (such as ibuprofen or naproxen) increases the risk of gastrointestinal side effects and should be avoided.
- Corticosteroids: These medications can increase the risk of gastrointestinal problems when taken with Zorvolex.
- ACE inhibitors or diuretics: These drugs may reduce the effectiveness of Zorvolex and increase the risk of kidney problems.
Alternatives to Zorvolex
- Ibuprofen: Another NSAID used for pain relief and inflammation, available over-the-counter.
- Naproxen: A longer-acting NSAID that provides relief from pain and inflammation.
- Celecoxib (Celebrex): A COX-2 selective NSAID, which may have a lower risk of gastrointestinal side effects compared to traditional NSAIDs like diclofenac.
- Acetaminophen (Tylenol): A pain reliever that may be used as an alternative to NSAIDs for mild pain without anti-inflammatory effects.
