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Yosprala
Yosprala is a combination medication that contains aspirin and omeprazole. It is used to reduce the risk of heart attack, stroke, and other cardiovascular events in patients who need aspirin therapy but are at risk of developing stomach ulcers. Aspirin is an antiplatelet agent that helps prevent blood clots, while omeprazole is a proton pump inhibitor (PPI) that helps reduce stomach acid, thereby reducing the risk of developing gastric ulcers or irritation caused by long-term aspirin use.
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Frequently Asked Questions
How long does it take for Yosprala to work?
Yosprala works to reduce the risk of heart attacks and strokes over time as part of long-term therapy. It does not provide immediate relief for heart-related conditions or symptoms.
Can I stop taking Yosprala if I feel fine?
No, Yosprala is typically prescribed for long-term use to prevent cardiovascular events. Stopping the medication suddenly can increase the risk of a heart attack or stroke. Always consult your healthcare provider before stopping any medication.
Can Yosprala be taken with other blood pressure medications?
Yes, Yosprala can be taken with blood pressure medications. However, it is important to discuss all medications with your healthcare provider to avoid potential interactions.
Is Yosprala safe during pregnancy?
Aspirin is not recommended during pregnancy, especially during the third trimester, due to the risk of bleeding complications. Women who are pregnant or planning to become pregnant should discuss safer alternatives with their healthcare provider.
What should I do if I miss a dose of Yosprala?
If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not take two doses at the same time to make up for the missed one.
Comprehensive Drug Guide
How Does Yosprala Work?
- Aspirin: An antiplatelet drug that prevents the formation of blood clots by inhibiting the enzyme cyclooxygenase (COX), which reduces the production of thromboxane, a chemical that promotes platelet aggregation and blood clotting.
- Omeprazole: A proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach, helping to protect the stomach lining from damage caused by aspirin, which can lead to ulcers and gastrointestinal bleeding.
Common Dosages
- 81 mg aspirin / 40 mg omeprazole
- 325 mg aspirin / 40 mg omeprazole
Typical Dosing
- The usual dose is one tablet taken once daily. The strength (either 81 mg or 325 mg of aspirin) will depend on the patient’s cardiovascular risk and the healthcare provider’s recommendation.
- It is important to take Yosprala 30 to 60 minutes before a meal to ensure proper absorption of the omeprazole component.
Typical Dosing
FDA Approved Indications
- Secondary prevention of cardiovascular events (such as heart attacks and strokes) in patients who require aspirin therapy and are at risk for developing aspirin-associated gastric ulcers.
Who Shouldn't Take Yosprala?
- Allergy to aspirin, omeprazole, or other NSAIDs
- Active bleeding disorders such as peptic ulcers or gastrointestinal bleeding
- Severe liver disease
- Asthma exacerbated by aspirin use
- Rye syndrome (aspirin should not be used in children or teenagers with viral infections, due to the risk of Reye’s syndrome)
Advice From The Pharmacist
- Take Yosprala once daily on an empty stomach, at least 30 to 60 minutes before a meal.
- Do not chew, crush, or split the tablet, as it is designed to release the medication at specific times.
- Avoid drinking alcohol while taking Yosprala, as this can increase the risk of stomach bleeding.
- Let your healthcare provider know if you are taking any other blood thinners or antacids, as these may interact with Yosprala.
- If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose. Do not take two doses at the same time.
Side Effects of Yosprala
Common Side Effects
- Upset stomach or heartburn
- Nausea
- Mild headache
- Diarrhea or constipation
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulcers (symptoms include black or tarry stools, vomiting blood)
- Allergic reactions (such as rash, swelling, difficulty breathing)
- Kidney problems (reduced urine output or swelling in the legs)
- Increased risk of fractures (due to long-term PPI use)
- Liver problems (yellowing of the skin or eyes, dark urine)
Risks and Warnings of Yosprala
- Gastrointestinal bleeding: Aspirin increases the risk of gastrointestinal bleeding and ulcers, especially in patients with a history of ulcers, heavy alcohol use, or those taking other NSAIDs. Omeprazole in Yosprala helps reduce this risk, but patients should still be monitored.
- Cardiovascular risk: Although aspirin reduces the risk of heart attacks and strokes, long-term use can increase the risk of bleeding. The benefits and risks of aspirin therapy should be discussed with a healthcare provider.
- Kidney function: Aspirin can impair kidney function, particularly in individuals with pre-existing kidney disease. Regular monitoring may be required.
- Reye’s syndrome: Aspirin should not be used in children or adolescents with viral infections, as it can lead to Reye’s syndrome, a serious condition affecting the liver and brain.
Interactions with Yosprala
Common Drug Interactions
- Blood thinners (warfarin, clopidogrel): Taking Yosprala with other anticoagulants or antiplatelet drugs increases the risk of bleeding.
- NSAIDs: Other nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen) can increase the risk of stomach bleeding when used with Yosprala.
- Antacids: Taking antacids or other acid-reducing drugs may interfere with the absorption of omeprazole.
- SSRIs or SNRIs: These antidepressants can increase the risk of bleeding when taken with aspirin.
- Methotrexate: Aspirin may increase the levels of methotrexate in the blood, leading to increased toxicity.
Alternatives to Yosprala
- Aspirin alone: For patients who are not at high risk of ulcers, aspirin may be used alone for cardiovascular protection.
- Plavix (clopidogrel): An antiplatelet drug that can be used as an alternative to aspirin in some patients.
- Aggrenox (aspirin/dipyridamole): A combination of aspirin and dipyridamole used to reduce the risk of stroke.
- Proton pump inhibitors (PPIs): Such as Prilosec (omeprazole) or Nexium (esomeprazole) can be used alongside aspirin to reduce the risk of gastrointestinal complications.
