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Dipyridamole

Dipyridamole is a medication renowned for its ability to prevent blood clots. Complications related to stroke or heart valve replacement are often averted using this med. A raised heart rate, a feeling of warmth, and mild headaches, among others, constitute some possible side effects. Remember, your health provider will only prescribe Dipyridamole if its benefits justify these inconveniences.

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Frequently Asked Questions

Can Dipyridamole cause headaches?
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Headache is a common, usually mild, and shortlasting side effect of Dipyridamole. Drinking enough water will often help with these headaches.

Can I stop taking Dipyridamole abruptly?
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No, abrupt discontinuation should be avoided. Always consult with your healthcare provider before making any changes to your medication regime.

Does Dipyridamole affect blood pressure?
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Yes, it can cause a decrease in blood pressure for some individuals.

What should I do if I miss a dose?
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If you miss a dose, take it as soon as possible unless it's almost time for your next dose. In that case, skip the missed dose. Do not double the next dose.

Comprehensive Drug Guide

How Does Dipyridamole Work?

Dipyridamole inhibits the activity of adenosine deaminase and phosphodiesterase, leading to an accumulation of adenosine and cyclic AMP, resulting in platelet activation inhibition, which reduces the risk of clot formation.

What is Dipyridamole Used For?

FDA indications: To reduce the risk of stroke in patients who have had or are at risk of stroke, and to prevent complications associated with artificial heart valve replacement.

Offlabel uses: Dipyridamole has been used to treat scleroderma (a group of autoimmune diseases that cause changes and damage to the skin, joints, and internal organs), and vasculitis.

Common Dosages

Tablets: 25mg, 50mg, and 75mg

Extendedrelease capsules (combination with aspirin): 200mg/25mg

Typical Dosing

FDA Approved Indications

  • Stroke prevention: 75 to 100mg, 4 times per day.
  • After mechanical heart valve implantation: 75 to 100mg, 4 times per day, and 1 aspirin tablet each day.

Off-Label Uses

  • Varying for offlabel uses, depending on condition severity and patient characteristics.

Who Shouldn't Take Dipyridamole?

  • Those allergic to dipyridamole.
  • Have an active bleeding disorder.
  • Suffering from a muscle condition called myasthenia gravis.
  • Individuals with a heart condition called unstable angina.
  • Pregnant women, unless specifically recommended by a healthcare provider.

Advice From The Pharmacist

  • Stay hydrated while on dipyridamole, as it prevents headaches associated with the medication.
  • This medication should be used with caution if you have low blood pressure.
  • If you experience dizziness, rise slowly from sitting or lying.
  • Inform your doctors that you're taking dipyridamole before undergoing any sort of surgery or dental procedures.
  • Do not discontinue the medication abruptly without consulting your doctor.
  • Abstain from alcohol as it may enhance the medication's blood pressurelowering effect.
  • Regular monitoring of liver function is essential.
  • Maintain a balanced diet, exercise, and cessation of smoking for optimal results.

Side Effects of Dipyridamole

Common Side Effects

  • Headache
  • Diarrhea
  • Dizziness
  • Stomach upset

Uncommon/Severe Side Effects

  • Uncommon side effects:
  • Low blood pressure
  • Rare side effects:
  • Gallstones
  • Liver problems
  • Rash
  • Severe side effects:
  • If you notice unusual bruising/bleeding, black or tarry stools, or other signs of bleeding, contact your healthcare provider immediately.

Risks and Warnings of Dipyridamole

  • It's crucial to know that Dipyridamole should be sidestepped if one is allergic to it.
  • If you're diagnosed with unstable angina or have an active bleeding disorder, Dipyridamole should be avoided.
  • Be wary if diagnosed with a muscle condition known as myasthenia gravis.
  • It should be used with caution under the supervision of a healthcare provider during pregnancy.
  • Regular doctor appointments and checkups are necessary to monitor the effects of this medication.

Interactions with Dipyridamole

Common Drug Interactions

  • Adenosine
  • Aspirin
  • Warfarin
  • Heparin
  • Betablockers

Alternatives to Dipyridamole

  • Plavix (Clopidogrel)
  • Effient (Prasugrel)
  • Brilinta (Ticagrelor)
  • Agrylin (Anagrelide)
  • Pletal (Cilostazol)