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Vilazodone HCl
Vilazodone HCl is the generic form of Viibryd, an antidepressant used to treat major depressive disorder (MDD) in adults. It combines the mechanisms of a selective serotonin reuptake inhibitor (SSRI) and a serotonin 5-HT1A receptor partial agonist, making it unique compared to standard SSRIs. Vilazodone increases serotonin levels in the brain, helping improve mood, sleep, energy levels, and interest in daily activities for individuals suffering from depression.
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Frequently Asked Questions
How long does it take for Vilazodone to start working?
It may take 1 to 2 weeks to notice improvements in symptoms of depression, but full effects may take up to 4 to 6 weeks.
Can Vilazodone cause weight gain?
Weight gain is not commonly associated with Vilazodone, but individual responses can vary. Some patients may experience changes in appetite or weight.
What should I do if I miss a dose of Vilazodone?
If you miss a dose, take it as soon as you remember unless it’s close to the time of your next dose. Do not double the dose to make up for a missed one.
Can Vilazodone cause insomnia?
Yes, insomnia is a potential side effect of Vilazodone. If you have trouble sleeping, consult your healthcare provider for guidance.
Can Vilazodone be used to treat anxiety?
While Vilazodone is primarily used for major depressive disorder, it may help relieve anxiety symptoms in some patients with depression. However, it is not specifically approved for the treatment of anxiety disorders.
Comprehensive Drug Guide
How Does Vilazodone HCl Work?
Vilazodone works by inhibiting the reuptake of serotonin in the brain, thereby increasing serotonin levels to improve mood and reduce depression symptoms. It also partially stimulates 5-HT1A receptors, which are involved in mood regulation, further enhancing its antidepressant effects.
Common Dosages
- 10 mg oral tablet
- 20 mg oral tablet
- 40 mg oral tablet
Typical Dosing
- Starting dose: 10 mg once daily for the first 7 days.
- After 7 days, the dose is typically increased to 20 mg once daily, and after another week, it may be increased to 40 mg once daily if needed.
- Vilazodone should be taken with food to enhance absorption and reduce the risk of stomach upset.
Typical Dosing
FDA Approved Indications
- Treatment of major depressive disorder (MDD) in adults.
Who Shouldn't Take Vilazodone HCl?
- Known hypersensitivity to vilazodone or any of its components.
- Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days due to the risk of serotonin syndrome.
- Severe liver impairment, as metabolism of the drug may be altered.
Advice From The Pharmacist
- Take Vilazodone with food to ensure better absorption and reduce gastrointestinal side effects like nausea.
- Do not stop taking Vilazodone suddenly, as this can lead to withdrawal symptoms. Always taper off the medication under medical supervision.
- Monitor your mood during the first few weeks of treatment. If you experience worsening depression or suicidal thoughts, contact your healthcare provider immediately.
- Avoid alcohol while taking Vilazodone, as it can increase the risk of dizziness or sedation.
Side Effects of Vilazodone HCl
Common Side Effects
- Diarrhea
- Nausea
- Headache
- Dizziness
- Dry mouth
Uncommon/Severe Side Effects
- Serotonin syndrome (agitation, hallucinations, rapid heart rate, fever)
- Increased risk of suicidal thoughts, particularly in young adults and adolescents.
- Hyponatremia (low sodium levels in the blood)
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Vilazodone HCl
- Serotonin Syndrome: Vilazodone can increase the risk of serotonin syndrome, a potentially life-threatening condition. Seek medical help if you experience agitation, hallucinations, rapid heartbeat, or fever.
- Suicidal Thoughts: Like other antidepressants, Vilazodone can increase the risk of suicidal thoughts and behaviors, particularly in younger individuals. Monitoring by a healthcare provider is essential during the initial phase of treatment.
- Withdrawal Symptoms: Discontinuing Vilazodone abruptly can lead to withdrawal symptoms, including irritability, dizziness, and sensory disturbances. Always taper off under medical guidance.
Interactions with Vilazodone HCl
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Combining Vilazodone with MAOIs increases the risk of serotonin syndrome. A gap of at least 14 days is required between discontinuing an MAOI and starting Vilazodone.
- Serotonergic drugs: Drugs that affect serotonin levels (e.g., SSRIs, SNRIs, triptans) increase the risk of serotonin syndrome.
- NSAIDs and anticoagulants: Using these medications alongside Vilazodone may increase the risk of bleeding.
- Alcohol: Avoid alcohol while taking Vilazodone, as it may intensify side effects like dizziness and sedation.
Alternatives to Vilazodone HCl
- Lexapro (escitalopram): An SSRI used to treat depression and anxiety disorders.
- Zoloft (sertraline): Another SSRI often prescribed for depression, anxiety, and other mood disorders.
- Cymbalta (duloxetine): A serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression and anxiety.
- Wellbutrin (bupropion): An atypical antidepressant often used for depression and smoking cessation.
