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Viibryd

Viibryd (generic name: vilazodone) is a selective serotonin reuptake inhibitor (SSRI) and serotonin receptor partial agonist used to treat major depressive disorder (MDD) in adults. It helps improve mood, energy levels, and interest in daily activities by enhancing the activity of serotonin, a neurotransmitter involved in regulating mood. Viibryd has a unique mechanism of action, combining SSRI effects with partial agonism at the serotonin 5-HT1A receptors.

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Frequently Asked Questions

How long does it take for Viibryd to start working?
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Viibryd may start improving symptoms of depression within 1 to 2 weeks, but it may take 4 to 6 weeks to experience the full therapeutic effects.

Can Viibryd cause weight gain?
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Weight gain is not commonly associated with Viibryd. However, individual responses to antidepressants vary, and some people may experience changes in appetite or weight.

What should I do if I miss a dose of Viibryd?
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If you miss a dose, take it as soon as you remember, unless it’s close to the time for your next dose. Do not double the dose to make up for a missed one.

Can Viibryd cause insomnia?
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Yes, insomnia is a potential side effect of Viibryd. If you experience trouble sleeping, discuss this with your healthcare provider, who may suggest adjustments to your treatment plan.

Can Viibryd be used for anxiety?
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Viibryd is approved for major depressive disorder (MDD) but may help relieve symptoms of anxiety in some patients with depression. However, it is not specifically approved for the treatment of anxiety disorders.

Comprehensive Drug Guide

How Does Viibryd Work?

Viibryd works by inhibiting the reuptake of serotonin in the brain, which increases serotonin levels and helps improve mood. Additionally, Viibryd is a partial agonist at the 5-HT1A receptors, which enhances serotonin signaling in a more targeted way, contributing to its antidepressant effects.

Common Dosages

  • 10 mg oral tablet
  • 20 mg oral tablet
  • 40 mg oral tablet

Typical Dosing

  • Starting dose: 10 mg once daily for 7 days.
  • After 7 days, the dose is typically increased to 20 mg once daily, with a further increase to 40 mg once daily after another 7 days, depending on patient response and tolerance.
  • Viibryd should be taken with food to improve absorption and effectiveness.

Typical Dosing

FDA Approved Indications

  • Treatment of major depressive disorder (MDD) in adults.

Who Shouldn't Take Viibryd?

  • Known hypersensitivity to vilazodone or any of its components.
  • Use of monoamine oxidase inhibitors (MAOIs) within the last 14 days due to the risk of serotonin syndrome.
  • Severe liver impairment, as the metabolism of vilazodone may be altered.

Advice From The Pharmacist

  • Take Viibryd with food to ensure better absorption and reduce the risk of stomach upset.
  • Do not stop taking Viibryd suddenly, as this may lead to withdrawal symptoms. Always taper off under medical supervision.
  • Monitor for mood changes, especially during the first few weeks of treatment. Report any worsening depression or thoughts of suicide to your healthcare provider immediately.
  • Avoid alcohol while taking Viibryd, as it may increase the risk of side effects like drowsiness or dizziness.

Side Effects of Viibryd

Common Side Effects

  • Diarrhea
  • Nausea
  • Dizziness
  • Trouble sleeping (insomnia)
  • Dry mouth

Uncommon/Severe Side Effects

  • Serotonin syndrome (symptoms include agitation, hallucinations, fever, rapid heartbeat)
  • Increased risk of suicidal thoughts and behavior in young adults and children
  • Hyponatremia (low sodium levels in the blood)
  • Severe allergic reactions (rash, swelling, difficulty breathing)

Risks and Warnings of Viibryd

  • Serotonin Syndrome: Viibryd can increase the risk of serotonin syndrome, a potentially life-threatening condition. Symptoms include agitation, hallucinations, rapid heart rate, fever, sweating, and muscle stiffness. Seek medical attention immediately if these symptoms occur.
  • Suicidal Thoughts: Antidepressants, including Viibryd, can increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults, particularly in the first few months of treatment. Patients should be closely monitored.
  • Withdrawal Symptoms: Abrupt discontinuation of Viibryd can cause withdrawal symptoms such as irritability, dizziness, sensory disturbances, and headache. Always taper off the medication under medical supervision.

Interactions with Viibryd

Common Drug Interactions

  • Monoamine oxidase inhibitors (MAOIs): Combining Viibryd with MAOIs increases the risk of serotonin syndrome. There should be at least a 14-day gap between stopping an MAOI and starting Viibryd.
  • Serotonergic drugs (e.g., triptans, other SSRIs, SNRIs): Increases the risk of serotonin syndrome when taken together.
  • NSAIDs and blood thinners (e.g., aspirin, warfarin): May increase the risk of bleeding when taken with Viibryd.
  • Alcohol: Avoid alcohol while taking Viibryd, as it can increase the sedative effects and the risk of dizziness or drowsiness.

Alternatives to Viibryd

  • Lexapro (escitalopram): An SSRI used to treat major depressive disorder and anxiety.
  • Zoloft (sertraline): Another SSRI used for depression, anxiety, and other mood disorders.
  • Cymbalta (duloxetine): A serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat depression and anxiety.
  • Wellbutrin (bupropion): An atypical antidepressant that works differently from SSRIs and SNRIs, often used for depression and smoking cessation.