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Venlafaxine HCl ER
Venlafaxine HCl ER (extended-release) is a prescription antidepressant in the serotonin-norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder. The extended-release formulation allows the medication to be taken once daily, offering a more gradual release of the active ingredient for longer-lasting effects throughout the day.
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Frequently Asked Questions
How long does it take for venlafaxine ER to start working?
It typically takes 2 to 4 weeks to start noticing improvements in mood or anxiety symptoms. Full effects may take up to 6 to 8 weeks.
Can I drink alcohol while taking venlafaxine ER?
It is best to avoid alcohol while taking venlafaxine, as alcohol can increase the risk of side effects such as dizziness, drowsiness, and impaired judgment.
What should I do if I miss a dose of venlafaxine ER?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Can venlafaxine ER cause weight gain?
Weight gain is possible but is generally less common with venlafaxine compared to other antidepressants. Some individuals may experience weight loss due to reduced appetite, especially early in treatment.
Is venlafaxine safe during pregnancy?
Venlafaxine should be used during pregnancy only if the potential benefit outweighs the risk. Always discuss with your healthcare provider if you are pregnant or planning to become pregnant while on venlafaxine.
Comprehensive Drug Guide
How Does Venlafaxine HCl ER Work?
Venlafaxine HCl ER works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters involved in mood regulation and anxiety. By increasing the availability of these chemicals in the brain, venlafaxine helps to improve mood, reduce feelings of anxiety, and alleviate depressive symptoms.
Common Dosages
- 37.5 mg
- 75 mg
- 150 mg
- 225 mg
Typical Dosing
- For depression and anxiety disorders: The usual starting dose is 75 mg once daily, which may be increased based on the patient’s response and tolerance. Maximum dose for depression is generally 225 mg per day.
- For panic disorder: The typical starting dose is 37.5 mg once daily, with gradual increases depending on response, up to 225 mg per day.
Typical Dosing
FDA Approved Indications
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
- Social anxiety disorder (SAD)
- Panic disorder
Off-Label Uses
Pediatric Dosing
Who Shouldn't Take Venlafaxine HCl ER?
- Known hypersensitivity to venlafaxine or any component of the formulation.
- Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
- Uncontrolled narrow-angle glaucoma.
Advice From The Pharmacist
- Take venlafaxine ER once daily, with food, to minimize the risk of gastrointestinal side effects such as nausea.
- Do not crush, chew, or split the extended-release capsules, as doing so can interfere with the time-release mechanism.
- It is important to take the medication at the same time each day to maintain consistent levels in your system.
- Avoid stopping venlafaxine suddenly, as it can lead to withdrawal symptoms such as dizziness, irritability, and flu-like symptoms. Your healthcare provider will gradually taper your dose if discontinuation is necessary.
Side Effects of Venlafaxine HCl ER
Common Side Effects
- Nausea
- Dizziness
- Dry mouth
- Insomnia
- Increased sweating
- Headache
- Sexual dysfunction (decreased libido or difficulty achieving orgasm)
Uncommon/Severe Side Effects
- High blood pressure
- Serotonin syndrome (a life-threatening condition caused by excessive serotonin)
- Suicidal thoughts (especially in young adults and adolescents)
- Severe allergic reactions (swelling, rash, difficulty breathing)
Risks and Warnings of Venlafaxine HCl ER
- Increased Suicidal Thoughts: Like other antidepressants, venlafaxine may increase the risk of suicidal thoughts and behaviors, especially in young adults, adolescents, and children. Monitoring by a healthcare provider is essential, particularly during the initial weeks of treatment.
- Serotonin Syndrome: This can occur when venlafaxine is taken with other drugs that increase serotonin levels, such as SSRIs, MAOIs, or certain pain medications. Symptoms include agitation, confusion, rapid heart rate, and muscle stiffness. Seek immediate medical attention if these occur.
- High Blood Pressure: Venlafaxine ER may increase blood pressure, particularly at higher doses. Regular monitoring of blood pressure is recommended.
Interactions with Venlafaxine HCl ER
Common Drug Interactions
- MAOIs: Venlafaxine should not be taken with MAOIs or within 14 days of stopping MAOIs, due to the risk of serotonin syndrome.
- Blood thinners (e.g., warfarin, aspirin): There may be an increased risk of bleeding when venlafaxine is used with anticoagulants or antiplatelet drugs.
- CYP2D6 inhibitors: Medications that inhibit the enzyme CYP2D6 (e.g., bupropion, fluoxetine) may increase venlafaxine levels and lead to more side effects.
Common Food Interactions
Alternatives to Venlafaxine HCl ER
- SSRIs (Selective Serotonin Reuptake Inhibitors): Medications like sertraline (Zoloft) or fluoxetine (Prozac) are often used as first-line treatments for depression and anxiety.
- Other SNRIs: Duloxetine (Cymbalta) is an SNRI that is used for depression, anxiety, and chronic pain conditions.
- Bupropion (Wellbutrin): Another antidepressant that works on norepinephrine and dopamine, often used in cases of sexual side effects with other antidepressants.
