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Venlafaxine Besylate ER
Venlafaxine Besylate ER is an extended-release antidepressant in the class of serotonin-norepinephrine reuptake inhibitors (SNRIs). It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder. By increasing levels of serotonin and norepinephrine in the brain, it helps regulate mood and reduce anxiety symptoms. The extended-release (ER) formulation allows for once-daily dosing, providing a controlled release of the medication over time.
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Frequently Asked Questions
How long does it take for venlafaxine ER to start working?
It usually takes 2 to 4 weeks for venlafaxine to show its full effects, although some people may experience improvements sooner. Continue taking the medication as prescribed, even if you don't feel immediate changes.
Can I drink alcohol while taking venlafaxine ER?
It is best to avoid alcohol while taking venlafaxine, as alcohol can increase the risk of dizziness, drowsiness, and impaired judgment.
Can venlafaxine cause weight gain?
Weight gain is possible with venlafaxine, but it is generally less common compared to other antidepressants. Some people may experience weight loss due to reduced appetite when starting the medication.
What should I do if I miss a dose of venlafaxine ER?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
Is venlafaxine ER safe during pregnancy?
Venlafaxine should only be used during pregnancy if the potential benefit outweighs the risk. Consult your healthcare provider if you are pregnant or planning to become pregnant while taking this medication.
Comprehensive Drug Guide
How Does Venlafaxine Besylate ER Work?
Venlafaxine Besylate ER works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters that influence mood, anxiety, and emotional stability. By increasing the availability of these chemicals in the brain, it helps improve symptoms of depression and anxiety disorders.
Common Dosages
- 37.5 mg
- 75 mg
- 150 mg
- 225 mg
Typical Dosing
- For depression and anxiety disorders: The typical starting dose is 75 mg once daily. Doses may be increased based on the patient’s response and tolerance, with a maximum daily dose of 225 mg.
- For panic disorder: Initial dosing usually starts at 37.5 mg once daily, with gradual increases as tolerated, up to 225 mg daily.
Typical Dosing
FDA Approved Indications
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
- Social anxiety disorder (SAD)
- Panic disorder
Who Shouldn't Take Venlafaxine Besylate ER?
- Known hypersensitivity to venlafaxine or any component of the formulation.
- Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI.
- Uncontrolled narrow-angle glaucoma.
Advice From The Pharmacist
- Take venlafaxine ER with food to minimize gastrointestinal side effects like nausea.
- Do not crush, chew, or split the extended-release capsules, as this may interfere with the controlled release of the medication.
- Do not stop taking venlafaxine suddenly, as this can lead to withdrawal symptoms, including dizziness, irritability, and flu-like symptoms. Your doctor will taper the dose if discontinuation is needed.
- It may take several weeks to see the full effects of venlafaxine, so continue taking it as prescribed even if you don’t feel immediate improvement.
Side Effects of Venlafaxine Besylate ER
Common Side Effects
- Nausea
- Drowsiness
- Dry mouth
- Headache
- Dizziness
- Sweating
- Insomnia
- Sexual dysfunction (decreased libido, difficulty achieving orgasm)
Uncommon/Severe Side Effects
- High blood pressure
- Serotonin syndrome (characterized by agitation, confusion, rapid heart rate, sweating, muscle stiffness, or tremors)
- Increased suicidal thoughts (particularly in young adults and adolescents)
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Venlafaxine Besylate ER
- Increased Suicidal Thoughts: Like other antidepressants, venlafaxine may increase the risk of suicidal thoughts and behaviors, especially in young adults, adolescents, and children. Careful monitoring is necessary during the first few weeks of treatment or when adjusting doses.
- Serotonin Syndrome: Taking venlafaxine with other medications that increase serotonin levels (e.g., SSRIs, MAOIs, triptans) can increase the risk of serotonin syndrome, a potentially life-threatening condition. Seek immediate medical attention if symptoms arise.
- Hypertension: Venlafaxine can cause increased blood pressure, especially at higher doses. Regular monitoring of blood pressure is recommended, particularly in patients with a history of hypertension.
Interactions with Venlafaxine Besylate ER
Common Drug Interactions
- Monoamine oxidase inhibitors (MAOIs): Combining venlafaxine with MAOIs can lead to serotonin syndrome. Avoid using MAOIs and venlafaxine together or within 14 days of stopping one before starting the other.
- Blood thinners (e.g., warfarin, aspirin): Venlafaxine may increase the risk of bleeding, particularly when taken with anticoagulants or antiplatelet drugs.
- Other serotonergic drugs (e.g., SSRIs, triptans): The risk of serotonin syndrome increases when venlafaxine is used in combination with other drugs that enhance serotonin activity.
Alternatives to Venlafaxine Besylate ER
- SSRIs (Selective Serotonin Reuptake Inhibitors): Medications such as sertraline (Zoloft) or fluoxetine (Prozac) are often used as first-line treatments for depression and anxiety.
- Other SNRIs: Duloxetine (Cymbalta) is an SNRI used for depression, anxiety, and chronic pain conditions.
- Bupropion (Wellbutrin): An alternative antidepressant that does not typically cause sexual side effects and works on norepinephrine and dopamine.
