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Vectical
Vectical (generic name: calcitriol) is a topical ointment used to treat mild to moderate plaque psoriasis in adults. Calcitriol is a form of vitamin D3, and it works by regulating the growth and development of skin cells, which helps reduce the scaling, redness, and thickness associated with psoriasis. Vectical is not a cure for psoriasis but helps manage its symptoms by slowing down the overproduction of skin cells.
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Frequently Asked Questions
How long does it take for Vectical to start working?
Improvement in psoriasis symptoms may be noticed within 2 weeks of starting Vectical, with full effects typically seen after 8 weeks of consistent use.
Can I use Vectical with other psoriasis treatments?
Yes, Vectical can be used in combination with other treatments for psoriasis, such as topical steroids or phototherapy. Always consult your healthcare provider for advice on combination therapy.
Is Vectical safe for long-term use?
Vectical is generally safe for long-term use under medical supervision, but regular monitoring of calcium levels is recommended, especially if large areas of the body are being treated.
Can I use moisturizers with Vectical?
Yes, you can use moisturizers while using Vectical. However, apply moisturizers after the medication has absorbed, usually 30 minutes after application.
Can Vectical be used for children?
Vectical is only approved for use in adults 18 years and older. It is not recommended for use in children.
Comprehensive Drug Guide
How Does Vectical Work?
Vectical contains calcitriol, which is a form of active vitamin D3. Calcitriol works by inhibiting the excessive proliferation of skin cells, a characteristic feature of plaque psoriasis. It also helps normalize the development of skin cells, reducing the formation of psoriatic plaques and improving symptoms like scaling, redness, and itching.
Common Dosages
- Topical ointment: 3 mcg/g of calcitriol.
Typical Dosing
- Apply a thin layer of Vectical ointment to the affected areas twice daily (morning and evening).
- Avoid applying it to the face, lips, or eyes. Wash your hands after applying the ointment unless treating the hands themselves.
Typical Dosing
FDA Approved Indications
- Mild to moderate plaque psoriasis in adults aged 18 years and older.
Who Shouldn't Take Vectical?
- Known hypersensitivity to calcitriol or any components of the formulation.
- Hypercalcemia or evidence of vitamin D toxicity.
- Severe kidney disease (without physician oversight).
Advice From The Pharmacist
- Apply Vectical only to affected skin and avoid getting it on healthy skin, eyes, lips, or mouth. If contact occurs, rinse thoroughly with water.
- Do not exceed the prescribed amount, as this may increase the risk of side effects, particularly high levels of calcium in the blood.
- You can still use moisturizers while using Vectical but apply them after the medication has absorbed (about 30 minutes).
- Avoid excessive exposure to natural or artificial sunlight (tanning beds) while using Vectical, as it may increase sensitivity to sunlight.
Side Effects of Vectical
Common Side Effects
- Itching
- Skin discomfort or burning
- Dry skin
- Redness
Uncommon/Severe Side Effects
- Hypercalcemia (elevated calcium levels), which can cause symptoms like nausea, vomiting, muscle weakness, and confusion.
- Severe skin irritation or allergic reactions (rash, swelling, difficulty breathing).
Risks and Warnings of Vectical
- Hypercalcemia: Excessive use of Vectical can lead to high calcium levels in the blood. This is more likely if large areas of the body are treated. If symptoms like nausea, weakness, or fatigue occur, contact your healthcare provider.
- Sun Sensitivity: Vectical can increase your skin’s sensitivity to sunlight. Always use sunscreen and protective clothing when outdoors, and avoid tanning beds while using this medication.
- Avoid Use on Face: Vectical should not be applied to sensitive areas like the face or skin folds, as it can cause irritation.
Interactions with Vectical
Common Drug Interactions
- Calcium supplements: Using calcium supplements or high doses of vitamin D may increase the risk of developing high calcium levels when using Vectical.
- Thiazide diuretics: These medications can also increase the risk of hypercalcemia when used alongside Vectical.
Alternatives to Vectical
- Calcipotriene (Dovonex): Another topical vitamin D analog used to treat plaque psoriasis.
- Topical corticosteroids: These are commonly used to reduce inflammation and irritation associated with psoriasis.
- Tazarotene (Tazorac): A topical retinoid used to treat plaque psoriasis and acne.
- Phototherapy: Light therapy used for treating psoriasis in more severe cases.
