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Dovonex
Dovonex (generic name: calcipotriene) is a topical medication used to treat plaque psoriasis. It is a synthetic form of vitamin D3 that helps slow down the overproduction of skin cells, which is a hallmark of psoriasis. Dovonex helps reduce the redness, scaling, and thickness of psoriatic plaques, making it an effective treatment for mild to moderate psoriasis.
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Frequently Asked Questions
How long does it take for Dovonex to work?
Most patients begin to see improvements within 2 weeks, but the full effect may take up to 8 weeks of consistent use.
Can I use Dovonex on my face?
No, Dovonex should not be applied to the face, as it may cause irritation. It is intended for use on the body and scalp.
Can Dovonex be used with other psoriasis treatments?
Yes, Dovonex is often used in combination with other psoriasis treatments like topical corticosteroids or phototherapy. Always consult your doctor before combining treatments.
Does Dovonex cause skin irritation?
Some users may experience mild irritation, itching, or redness at the application site, especially if applied too frequently. If irritation occurs, reduce the frequency of use.
Is Dovonex safe for long-term use?
Yes, but long-term use should be monitored by a healthcare provider to avoid potential side effects like hypercalcemia.
Comprehensive Drug Guide
How Does Dovonex Work?
Dovonex works by regulating skin cell production. In psoriasis, skin cells are produced too quickly, causing a buildup of thick, scaly patches. Calcipotriene (the active ingredient in Dovonex) helps normalize the rate of skin cell turnover, reducing the plaques' size and severity.
Common Dosages
- Cream: 0.005% calcipotriene
- Ointment: 0.005% calcipotriene
- Scalp solution: 0.005% calcipotriene
Typical Dosing
- The typical dosing for Dovonex involves applying a thin layer of the cream, ointment, or solution to the affected areas once or twice daily. Avoid applying to the face or areas of broken skin.
Typical Dosing
FDA Approved Indications
- Plaque psoriasis
Who Shouldn't Take Dovonex?
- Hypercalcemia (high blood calcium levels)
- Known hypersensitivity to calcipotriene or other ingredients in the formulation
Advice From The Pharmacist
- Apply Dovonex only to the areas affected by psoriasis and avoid contact with healthy skin or mucous membranes.
- Wash your hands thoroughly after applying Dovonex unless you are treating your hands.
- Avoid excessive exposure to sunlight or UV lamps while using Dovonex, as this can increase the risk of skin irritation.
- If using the scalp solution, ensure the medication does not get into your eyes or mouth.
Side Effects of Dovonex
Common Side Effects
- Skin irritation at the application site
- Itching or dryness
- Redness
Uncommon/Severe Side Effects
- Hypercalcemia (elevated calcium levels in the blood)
- Severe skin irritation or rash
- Worsening of psoriasis in rare cases
Risks and Warnings of Dovonex
- Hypercalcemia: Overuse of Dovonex can lead to elevated calcium levels in the blood. Patients should avoid applying excessive amounts or using it over large areas of skin.
- Skin Irritation: Some patients may experience skin irritation, particularly if they apply Dovonex to sensitive areas like the face or groin. If irritation occurs, reduce the frequency of application or consult your healthcare provider.
- Photosensitivity: Dovonex can increase your skin’s sensitivity to sunlight, so it’s important to use sunscreen and avoid prolonged sun exposure.
Interactions with Dovonex
Common Drug Interactions
- Other topical medications: Combining Dovonex with other topical products, especially steroids or salicylic acid, should be done under the guidance of a healthcare provider.
- Calcium supplements: Using calcipotriene in combination with calcium supplements can increase the risk of hypercalcemia.
Alternatives to Dovonex
- Taclonex: A combination of calcipotriene and betamethasone dipropionate used to treat plaque psoriasis.
- Topical corticosteroids: Such as betamethasone or clobetasol, often used to reduce inflammation and scaling in psoriasis.
- Tazarotene (Tazorac): A topical retinoid used to treat plaque psoriasis.
- Coal tar: A traditional treatment for psoriasis that helps reduce scaling and inflammation.
