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Tazarotene
Tazarotene (brand name: Tazorac) is a topical retinoid used for treating acne, plaque psoriasis, and fine wrinkles caused by sun damage. It works by modulating skin cell behavior, promoting cell turnover, and reducing the formation of acne lesions or thickened skin plaques. Tazarotene is available in cream and gel forms and is used as part of long-term treatment regimens for these conditions.
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Frequently Asked Questions
How long does it take for tazarotene to start working?
For acne, improvement is typically seen after 4 to 8 weeks of consistent use. For psoriasis, results may begin to appear in 2 to 4 weeks.
Can I use tazarotene with other acne medications?
Avoid using irritating topical products such as benzoyl peroxide or salicylic acid at the same time as tazarotene unless directed by your doctor. You may be advised to alternate their use (e.g., one in the morning and tazarotene at night).
What should I do if I miss a dose?
If you miss a dose, apply the medication as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Can I wear makeup while using tazarotene?
Yes, you can wear makeup while using tazarotene. However, make sure to apply tazarotene to clean skin, and use non-comedogenic makeup products to avoid clogging pores.
Is tazarotene safe for long-term use?
Tazarotene can be used long-term under a doctor’s supervision. It is important to monitor for side effects like skin irritation or increased sun sensitivity. Long-term use for acne or psoriasis is generally considered safe with proper care.
Comprehensive Drug Guide
How Does Tazarotene Work?
Tazarotene is a prodrug that is converted into its active form, tazarotenic acid, after being applied to the skin. It binds to retinoic acid receptors (RARs) in the skin, modulating gene expression and affecting the growth and differentiation of skin cells. This helps to normalize the shedding of skin cells in acne, reduces inflammation, and decreases the formation of plaques in psoriasis. Tazarotene also promotes collagen production, which can improve the appearance of fine wrinkles.
Common Dosages
- 0.05% and 0.1% cream or gel.
Typical Dosing
- For acne: Apply a thin layer of 0.1% cream or gel once daily, preferably in the evening, to the affected areas after cleansing.
- For plaque psoriasis: Apply a thin layer of 0.05% or 0.1% cream or gel once daily to the psoriatic plaques.
- For fine wrinkles and hyperpigmentation: Apply a thin layer of 0.1% cream or gel once daily at bedtime to the affected areas.
Typical Dosing
FDA Approved Indications
- Acne vulgaris in adults and adolescents aged 12 years and older.
- Plaque psoriasis in adults.
- Fine wrinkles and hyperpigmentation due to sun damage (photodamage).
Who Shouldn't Take Tazarotene?
- Hypersensitivity to tazarotene or any components of the formulation.
- Pregnancy: Tazarotene is classified as Pregnancy Category X due to the risk of fetal harm. Women of childbearing potential should use effective contraception while using tazarotene.
Advice From The Pharmacist
- Apply tazarotene once daily in the evening, using a thin layer. Avoid using more than directed, as this can increase the risk of irritation.
- Use sunscreen during the day, as tazarotene increases sensitivity to sunlight. Use a broad-spectrum sunscreen with at least SPF 30 and wear protective clothing.
- Moisturize regularly, as tazarotene can cause dryness and peeling. Applying moisturizer after the medication can help reduce irritation.
- Avoid using other skin irritants, such as salicylic acid, alpha-hydroxy acids, or harsh cleansers, unless recommended by your doctor.
- Women of childbearing age should use effective birth control and avoid becoming pregnant while using tazarotene due to the risk of birth defects.
Side Effects of Tazarotene
Common Side Effects
- Skin irritation (redness, burning, stinging, or itching)
- Dryness and peeling
- Increased sensitivity to sunlight
- Temporary worsening of acne during the first few weeks of treatment
Uncommon/Severe Side Effects
- Severe skin irritation or blistering
- Allergic reactions, such as swelling, rash, or difficulty breathing
Risks and Warnings of Tazarotene
- Pregnancy Risk: Tazarotene is contraindicated in pregnancy due to its potential to cause birth defects. Women of childbearing potential should use effective contraception during treatment and for at least one month after discontinuing the medication.
- Sun Sensitivity: Tazarotene makes the skin more sensitive to UV light, increasing the risk of sunburn. Use sunscreen daily and avoid prolonged exposure to the sun or tanning beds.
- Initial Worsening: Acne may initially worsen during the first few weeks of treatment as the skin adjusts. This is common, and improvements should be seen after 4 to 8 weeks of consistent use.
Interactions with Tazarotene
Common Drug Interactions
Tazarotene has minimal systemic absorption, so drug interactions are rare. However, using other topical treatments with irritating ingredients, such as benzoyl peroxide, salicylic acid, or other retinoids, should be avoided unless recommended by your healthcare provider.
Alternatives to Tazarotene
- Adapalene (Differin): A topical retinoid available over-the-counter for acne treatment.
- Tretinoin (Retin-A): Another commonly used topical retinoid for acne, hyperpigmentation, and wrinkles.
- Calcipotriene (Dovonex): A topical vitamin D analog used for treating plaque psoriasis.
- Benzoyl Peroxide: An antibacterial agent often used in combination with retinoids for acne treatment.
