Calcipotriene

The typical dosage of calcipotriene for adults with plaque psoriasis is:

• Topical Cream/Ointment: Apply a thin layer to the affected areas once or twice daily as directed by a healthcare provider.
• Topical Solution (for scalp psoriasis): Apply to the affected scalp areas once or twice daily, usually after shampooing.

Calcipotriene is contraindicated in patients with:

• Known hypersensitivity to calcipotriene or any of the components in the formulation.
• Hypercalcemia (high levels of calcium in the blood) or evidence of vitamin D toxicity, as calcipotriene can affect calcium metabolism.
• Use on the face or in skin folds where the skin is thin, as this can increase the risk of irritation and adverse effects.

Patients using calcipotriene should be advised to:

• Apply the medication exactly as prescribed and not exceed the recommended amount, as overuse can lead to skin irritation and increased calcium levels in the blood.
• Avoid exposure to natural or artificial sunlight (such as tanning beds) on treated areas, as calcipotriene can make the skin more sensitive to UV light.
• Inform their healthcare provider if they experience any signs of skin irritation, such as burning, stinging, or redness, especially if it persists or worsens.
• Use the medication regularly for the best results, but avoid using it on areas of broken or infected skin.
• Report any signs of hypercalcemia, such as nausea, vomiting, weakness, or confusion, to their healthcare provider immediately.

• Skin irritation at the site of application (such as redness, itching, or dryness)
• Burning or stinging sensation
• Peeling or scaling of the skin
• Rash or worsening of psoriasis (in some cases)

Serious side effects can include:

• Hypercalcemia: Although rare, overuse of calcipotriene can lead to elevated levels of calcium in the blood. Symptoms include nausea, vomiting, constipation, and confusion.
• Severe Skin Irritation: If the irritation is severe or does not improve with continued use, the medication should be discontinued, and the healthcare provider should be consulted.

• Hypercalcemia: Patients using large amounts of calcipotriene or applying it to large body areas are at risk of developing hypercalcemia. Blood calcium levels should be monitored, especially if high doses or prolonged treatment is required.
• Photosensitivity: Calcipotriene can make the skin more sensitive to sunlight, increasing the risk of sunburn. Sun exposure should be minimized, and sun protection measures (such as using sunscreen and wearing protective clothing) should be followed.

Calcipotriene may interact with other medications, including:

• Topical Corticosteroids: When used together, there may be an increased risk of skin irritation. However, they are sometimes used in combination under the guidance of a healthcare provider to enhance treatment effectiveness.
• Calcium Supplements or Vitamin D Analogs: Concomitant use with other vitamin D products or calcium supplements may increase the risk of hypercalcemia.

Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.

Alternative treatments for plaque psoriasis include:

• Topical Corticosteroids: Such as hydrocortisone or betamethasone, which reduce inflammation and itching.
• Topical Retinoids: Such as tazarotene, which can also normalize skin cell growth.
• Coal Tar Preparations: Which help to slow down the rapid growth of skin cells and reduce scaling.
• Phototherapy: Treatment with ultraviolet light under medical supervision can be effective in reducing psoriasis symptoms.

The choice of treatment depends on the severity of the psoriasis, patient preferences, and the response to previous treatments.