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Tazorac
Tazorac (generic name: tazarotene) is a topical retinoid used to treat a variety of skin conditions, including acne, psoriasis, and fine wrinkles due to sun damage. Tazarotene works by affecting the growth of skin cells, helping to reduce inflammation and prevent the formation of acne or psoriasis plaques. It is available in both cream and gel forms and comes in various strengths depending on the condition being treated.
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Frequently Asked Questions
How long does it take for Tazorac to work?
For acne, noticeable improvements may begin after 4 to 8 weeks of consistent use. For psoriasis, improvements may be seen after 1 to 4 weeks. Photodamage improvements may take several months.
Can I use Tazorac with other acne medications?
Avoid using other topical treatments, such as benzoyl peroxide or salicylic acid, simultaneously with Tazorac unless advised by your doctor, as they can increase irritation. Use these treatments at different times of day if necessary.
Can I wear makeup while using Tazorac?
Yes, makeup can be worn while using Tazorac, but ensure your skin is clean and dry before applying the medication. Use non-comedogenic makeup to avoid clogging pores.
What should I do if I miss a dose?
If you miss a dose, apply Tazorac as soon as you remember. If it is close to the time of your next dose, skip the missed dose and apply the next dose at the regular time. Do not double up doses.
Can Tazorac be used on sensitive skin?
Tazorac can cause irritation, especially on sensitive skin. Use it cautiously, starting with a lower strength (0.05%) and applying it every other day until your skin adjusts. Moisturizing can help reduce irritation.
Comprehensive Drug Guide
How Does Tazorac Work?
Tazarotene is a prodrug that is converted to its active form (tazarotenic acid) after application to the skin. It binds to retinoic acid receptors (RARs) in the skin, regulating the growth and differentiation of skin cells. This action helps to reduce acne by preventing the formation of comedones (blocked pores) and to decrease the overproduction of skin cells in psoriasis. Tazarotene also promotes cell turnover, which can improve the appearance of fine wrinkles.
Common Dosages
- 0.05% and 0.1% cream or gel.
Typical Dosing
- For acne: Apply a thin layer of 0.1% gel or cream once daily, preferably in the evening, to the affected areas after cleansing.
- For plaque psoriasis: Apply a thin layer of 0.05% or 0.1% cream or gel once daily to the affected areas.
- For photodamage: Apply a thin layer of 0.1% cream or gel once daily at bedtime.
Typical Dosing
FDA Approved Indications
- Acne vulgaris in adults and adolescents aged 12 years and older.
- Plaque psoriasis in adults.
- Reduction of facial fine wrinkles and discoloration caused by sun damage (photodamage).
Who Shouldn't Take Tazorac?
- Hypersensitivity to tazarotene or any of its components.
- Pregnancy: Tazorac is classified as Category X for pregnancy, meaning it can cause harm to the fetus and should not be used during pregnancy.
Advice From The Pharmacist
- Apply a thin layer to the affected areas once daily in the evening. Avoid applying more than directed, as this will not increase efficacy but can increase irritation.
- Avoid direct sun exposure, as tazarotene can make your skin more sensitive to sunlight and increase the risk of sunburn. Use sunscreen and protective clothing during the day.
- Do not use on eczematous skin or open wounds, as it may cause severe irritation.
- Moisturize regularly, especially if treating acne or psoriasis, as tazarotene can cause dryness and peeling. Apply moisturizer after using Tazorac to reduce irritation.
- Women of childbearing potential should use effective contraception during treatment and for one month after discontinuation to prevent pregnancy.
Side Effects of Tazorac
Common Side Effects
- Skin irritation (redness, peeling, burning, or itching)
- Dryness or flaking
- Increased sensitivity to sunlight
- Worsening of acne initially
Uncommon/Severe Side Effects
- Severe skin irritation: If your skin becomes excessively red, swollen, or blistered, discontinue use and consult your doctor.
- Allergic reactions, such as rash, itching, or swelling, particularly if involving the face, lips, or throat.
Risks and Warnings of Tazorac
- Pregnancy Risk: Tazarotene is contraindicated during pregnancy due to the risk of fetal harm. Women should use effective contraception while using this medication and for at least one month after discontinuing the medication.
- Sun Sensitivity: Tazorac can make your skin more susceptible to sunburn. Use sunscreen with at least SPF 30 and avoid tanning beds or prolonged sun exposure.
- Initial Worsening: Acne may worsen in the first few weeks of treatment as your skin adjusts to the medication. This is normal, and improvements should be seen after several weeks of consistent use.
Interactions with Tazorac
Common Drug Interactions
Tazorac is a topical medication and has minimal systemic absorption, so drug interactions are rare. However, avoid using other topical products with irritating effects (such as salicylic acid, benzoyl peroxide, or other retinoids) unless recommended by your doctor.
Alternatives to Tazorac
- Adapalene (Differin): Another topical retinoid used for acne, available over-the-counter in lower strengths.
- Tretinoin (Retin-A): A widely used topical retinoid for acne and photodamage.
- Calcipotriene (Dovonex): A topical vitamin D analog used for treating plaque psoriasis.
- Benzoyl Peroxide: A topical antibacterial agent for acne, often used in combination with retinoids.
- Salicylic Acid: A topical keratolytic agent used to treat acne, often used as a gentler alternative to retinoids.
