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Vandazole
Vandazole, the brand name for metronidazole vaginal gel, is an antibiotic used to treat bacterial vaginosis (BV), a condition caused by an imbalance of the natural bacteria in the vagina. Metronidazole works by stopping the growth of certain bacteria, helping to restore the natural balance in the vagina and relieve symptoms such as discharge, odor, and discomfort. It is applied intravaginally and is specifically designed for use in women with BV.
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Frequently Asked Questions
How long does it take for Vandazole to work?
You may begin to notice improvements in symptoms such as discharge and odor within 2 to 3 days of starting treatment, but it is important to finish the full 5-day course to ensure the infection is fully treated.
Can I use Vandazole during my period?
Yes, Vandazole can be used during your menstrual period. However, you may want to avoid using tampons during treatment, as they may absorb some of the medication. Use sanitary pads instead.
What should I do if I miss a dose of Vandazole?
If you miss a dose, use it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can I have sex while using Vandazole?
It is recommended to avoid sexual intercourse during treatment, as Vandazole may weaken condoms and diaphragms, reducing their effectiveness. This helps ensure the best treatment outcome and avoids transmitting or worsening the infection.
Can Vandazole treat yeast infections?
No, Vandazole is specifically used to treat bacterial vaginosis. It is not effective against yeast infections, which are caused by fungi, not bacteria.
Comprehensive Drug Guide
How Does Vandazole Work?
Vandazole works by inhibiting the nucleic acid synthesis of bacteria, which disrupts their DNA and prevents them from multiplying. This action specifically targets anaerobic bacteria, the type of bacteria commonly responsible for bacterial vaginosis. By eliminating the harmful bacteria, Vandazole helps to restore the normal balance of bacteria in the vagina.
Common Dosages
- Vandazole is available as a 0.75% metronidazole vaginal gel. Each applicator delivers 5 grams of gel containing 37.5 mg of metronidazole.
Typical Dosing
- The usual dose is one applicatorful (5 grams) of Vandazole inserted into the vagina once daily at bedtime for 5 consecutive days.
- The gel is applied using a pre-filled applicator, which should be inserted intravaginally.
Typical Dosing
FDA Approved Indications
- Treatment of bacterial vaginosis (BV) in adult women.
Who Shouldn't Take Vandazole?
- Known hypersensitivity to metronidazole or other components of the gel.
- Alcohol consumption during and for at least 24 hours after treatment, due to the risk of a disulfiram-like reaction (nausea, vomiting, flushing).
Advice From The Pharmacist
- Insert one full applicator of Vandazole into the vagina at bedtime for 5 days. Follow your healthcare provider's instructions closely to ensure the infection is fully treated.
- Avoid drinking alcohol while using Vandazole and for at least 24 hours after completing treatment, as combining alcohol with metronidazole may cause a disulfiram-like reaction (severe nausea, vomiting, flushing, and headache).
- If you experience any vaginal irritation or discomfort while using Vandazole, inform your healthcare provider. Some mild irritation is common, but persistent discomfort should be evaluated.
- Finish the entire course of treatment, even if your symptoms improve before the 5-day period is over. Stopping treatment early may cause the infection to return.
- Avoid sexual intercourse during treatment, as Vandazole may weaken condoms and diaphragms, reducing their effectiveness in preventing pregnancy or sexually transmitted infections (STIs).
Side Effects of Vandazole
Common Side Effects
- Vaginal irritation or burning
- Vaginal discharge
- Mild abdominal cramps
- Nausea or upset stomach
- Headache
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Severe vaginal irritation or discharge
- Neurological symptoms (seizures or numbness, though this is more common with oral metronidazole)
Risks and Warnings of Vandazole
- Alcohol interaction: Drinking alcohol during treatment or within 24 hours after the last dose can cause a disulfiram-like reaction, leading to severe nausea, vomiting, flushing, and headache.
- Vaginal irritation: Some patients may experience mild vaginal irritation, but severe or persistent irritation should be reported to a healthcare provider.
- Condom or diaphragm weakening: Vandazole may weaken latex condoms or diaphragms, so alternative contraceptive methods should be considered during treatment to prevent pregnancy and STIs.
Interactions with Vandazole
Common Drug Interactions
- Alcohol: Consuming alcohol during treatment with Vandazole and for 24 hours after the last dose may cause severe side effects such as nausea, vomiting, and flushing.
- Anticoagulants (warfarin): Metronidazole can increase the effect of warfarin, increasing the risk of bleeding. Close monitoring of blood clotting parameters may be required.
- Lithium: Concomitant use of metronidazole may increase lithium levels in the blood, leading to toxicity.
- Disulfiram: Patients should avoid using metronidazole with disulfiram, as it may cause acute psychosis or confusion.
Alternatives to Vandazole
- Clindamycin (Cleocin Vaginal Cream): Another antibiotic used to treat bacterial vaginosis, available as a vaginal cream.
- Oral metronidazole (Flagyl): The oral form of metronidazole is also used to treat bacterial vaginosis but may cause more systemic side effects.
- Tinidazole (Tindamax): An oral antibiotic similar to metronidazole, used for treating bacterial vaginosis and certain protozoal infections.
- Secnidazole (Solosec): A single-dose oral antibiotic used to treat bacterial vaginosis.
