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Cleocin
Cleocin (clindamycin) is a lincosamide antibiotic used to treat a variety of bacterial infections, including skin infections, respiratory infections, pelvic infections, and bone infections. It works by inhibiting bacterial protein synthesis, effectively stopping the growth of bacteria. Cleocin is commonly prescribed for infections caused by anaerobic bacteria and some gram-positive bacteria.
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Frequently Asked Questions
How long does it take for Cleocin to work?
Cleocin generally starts to work within a few days of starting the treatment. Complete the full course even if you feel better before finishing the medication.
Can Cleocin be used for acne?
Yes, Cleocin is sometimes used topically to treat acne due to its ability to kill acne-causing bacteria.
What should I do if I miss a dose of Cleocin?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Can Cleocin cause diarrhea?
Yes, diarrhea is a common side effect of Cleocin. However, severe diarrhea, especially with blood or mucus, may indicate a serious condition known as Clostridium difficile-associated diarrhea.
Does Cleocin interact with other antibiotics?
Yes, Cleocin can interact with some antibiotics, such as erythromycin, leading to reduced effectiveness. Inform your healthcare provider about all medications you are taking.
Comprehensive Drug Guide
How Does Cleocin Work?
Cleocin works by binding to the 50S ribosomal subunit of bacteria, inhibiting protein synthesis. This prevents the bacteria from producing essential proteins needed for growth, effectively stopping bacterial proliferation and allowing the body's immune system to fight the infection.
Common Dosages
- Oral capsules: 150 mg, 300 mg
- Topical solution: 1%
- Vaginal suppositories: 100 mg
- Injectable solution
Typical Dosing
- For skin infections: The usual oral dose is 150 to 450 mg every 6 to 8 hours, depending on the severity of the infection.
- For topical use: Apply the topical solution twice daily to the affected area.
- For vaginal infections: Insert one vaginal suppository at bedtime for 3 to 7 days, as directed by your healthcare provider.
Typical Dosing
FDA Approved Indications
- Skin and soft tissue infections
- Respiratory tract infections
- Intra-abdominal infections
- Pelvic inflammatory disease
- Bone and joint infections
Who Shouldn't Take Cleocin?
- Known hypersensitivity to clindamycin or lincomycin.
- Ulcerative colitis or Crohn’s disease (increased risk of severe diarrhea and colitis).
Advice From The Pharmacist
- Take Cleocin with a full glass of water to avoid irritation of the esophagus.
- If you are taking the oral form, do not lie down immediately after taking it to reduce the risk of esophageal irritation.
- Report any signs of severe diarrhea or stomach pain, as this could be a sign of Clostridium difficile-associated diarrhea (CDAD), a serious side effect of antibiotics like Cleocin.
- Complete the full course of Cleocin, even if you feel better before finishing the prescription.
Side Effects of Cleocin
Common Side Effects
- Nausea
- Diarrhea
- Stomach pain
- Rash
- Vaginal itching or discharge (with vaginal use)
Uncommon/Severe Side Effects
- Clostridium difficile-associated diarrhea (CDAD)
- Severe allergic reactions (swelling, difficulty breathing)
- Liver toxicity
Risks and Warnings of Cleocin
- Clostridium difficile Infection: Cleocin can increase the risk of severe, sometimes life-threatening diarrhea caused by Clostridium difficile. This condition can occur during or after antibiotic treatment.
- Allergic Reactions: Cleocin can cause severe allergic reactions, including anaphylaxis. Discontinue use and seek medical attention if you experience signs of an allergic reaction.
- Superinfections: Prolonged use of antibiotics can lead to the overgrowth of nonsusceptible organisms, including fungi.
Interactions with Cleocin
Common Drug Interactions
- Neuromuscular blocking agents: Cleocin may enhance the effects of neuromuscular blocking agents, leading to prolonged muscle relaxation.
- Erythromycin: Concurrent use of Cleocin and erythromycin may lead to reduced effectiveness of both medications due to competitive binding at the same site.
Alternatives to Cleocin
- Doxycycline: An alternative antibiotic used for skin, respiratory, and other bacterial infections.
- Metronidazole (Flagyl): An antibiotic commonly used for anaerobic bacterial infections and vaginal infections.
- Amoxicillin-clavulanate (Augmentin): A broad-spectrum antibiotic used for a wide variety of bacterial infections.
