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Tinidazole
Tinidazole is an antibiotic that fights bacteria in the body. It's used to treat certain types of vaginal infections like bacterial vaginosis. It's also used to treat certain types of parasite infections. Common side effects include nausea, stomach cramps, and a metallic taste in the mouth. Like all antibiotics, it's important to take the full course to ensure that the infection is completely cleared from the body.
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Frequently Asked Questions
Can I consume alcohol while on Tinidazole?
No, alcohol can react with tinidazole causing severe nausea and vomiting. It's recommended to avoid alcohol during treatment and at least 3 days after the last dose.
Can I stop taking Tinidazole if I feel better?
No, you should complete the full course of medication to ensure the infection is fully cleared and to avoid the risk of the infection coming back. Always follow your doctor's instructions.
Does Tinidazole affect birth control?
It may reduce the effectiveness of some birth control pills leading to unintentional pregnancy. It?s wise to use an additional form of contraception whilst taking this medication.
I missed a dose of Tinidazole, what should I do?
If it's near the time for your next dose, skip the missed dose. If there is plenty of time before your next dose, take it as soon as you remember. Don't double up the doses!
Comprehensive Drug Guide
How Does Tinidazole Work?
Tinidazole interrupts the DNA replication process of susceptible, anaerobic microorganisms, resulting in cell death and eliminating the infection.
What is Tinidazole Used For?
FDA indications: Tinidazole is used to treat bacterial vaginosis in women. It's also used to treat certain parasitic infections like giardiasis and amebiasis.
Offlabel uses: Tinidazole has also been used offlabel for the treatment of infections caused by other anaerobic bacteria, and helicobacter pylori (the bacteria responsible for stomach ulcers).
Common Dosages
Tablets: 250mg, 500mg
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Bacterial vaginosis: 2g single dose, or 1 g per day for two days.
- Giardiasis: 2g single dose.
- Amebiasis: 2 g per day for three days.
Off-Label Uses
- For offlabel uses:
- Other anaerobic infections: Dosage varies, but often 2 g single dose.
- Helicobacter pylori infection: 1 g per day for two days, in combination with other medications.
Who Shouldn't Take Tinidazole?
- Have ever had an allergic reaction to tinidazole or similar medicines such as metronidazole (Flagyl).
- Are in the first trimester of pregnancy.
- Are breastfeeding a baby.
- Have a blood cell disorder such as anemia or low white cell counts.
- Have a seizure disorder.
- Have kidney disease (or if you are on dialysis).
- Have liver disease.
- Have any other infections (such as a viral infection).
Advice From The Pharmacist
- Avoid alcohol. Tinidazole can react with alcohol leading to upset stomach, vomiting, stomach cramps, headaches, flushing, and sweating.
- Tinidazole can be taken with or without food, but taking it with food can help avoid an upset stomach.
- It's important to take the full course of tinidazole, even if you're feeling better, to ensure that the infection is fully cleared.
- Birth control pills may not work as effectively whilst you're taking this medicine, use other forms of contraception to avoid unintentional pregnancy.
- Avoid exposure to strong sunlight or artificial UV light, tinidazole can make your skin more sensitive to sun.
Side Effects of Tinidazole
Common Side Effects
- Nausea, vomiting, upset stomach.
- Metallic or bitter taste in your mouth.
- Loss of appetite.
- Constipation, diarrhea.
- Feeling tired or weak.
- Feeling dizzy.
- Vaginal itching or discharge may occur in women.
Uncommon/Severe Side Effects
- Rare side effects:
- Pancreatitis.
- Unusual fatigue.
- Severe side effects:
- If you have a severe allergic reaction (hives, difficulty breathing, swelling in your face or throat) seek emergency medical attention.
Risks and Warnings of Tinidazole
- Tinidazole shouldn't be used during the first trimester of pregnancy.
- Avoid alcohol: Tinidazole and alcohol do not mix well and can lead to severe nausea and vomiting.
- It should be used with caution in patients with kidney function problems or liver disease.
- Tinidazole can cause candida overgrowth, leading to thrush in women.
Interactions with Tinidazole
Common Drug Interactions
- Warfarin or other blood thinners.
- Antifungals such as fluconazole.
- Certain seizure medications.
- Disulfiram.
Alternatives to Tinidazole
- Metronidazole
- Clindamycin
- Azithromycin
