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Twynsta
Twynsta is a combination prescription medication used to treat high blood pressure (hypertension). It contains two active ingredients: telmisartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker (CCB). These medications work together to relax blood vessels, lower blood pressure, and reduce the risk of strokes, heart attacks, and kidney problems. Twynsta is often prescribed when blood pressure is not adequately controlled with a single medication.
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Frequently Asked Questions
How long does it take for Twynsta to work?
Twynsta begins to lower blood pressure within a few hours of taking a dose, but it may take several weeks to see the full effect. Consistent use is important for optimal blood pressure control.
Can Twynsta be taken with other blood pressure medications?
Yes, Twynsta is often prescribed with other blood pressure medications, particularly if additional blood pressure control is needed. Always follow your healthcare provider’s guidance on combining medications.
Can I stop taking Twynsta if my blood pressure is under control?
No, you should not stop taking Twynsta without consulting your healthcare provider. Blood pressure control typically requires ongoing treatment, even if you feel well.
What should I do if I experience dizziness while taking Twynsta?
Dizziness is a common side effect, particularly when starting Twynsta or increasing the dose. If dizziness persists or is severe, contact your healthcare provider. It may help to stand up slowly from sitting or lying down to reduce the risk of dizziness.
Can I drink alcohol while taking Twynsta?
It is best to limit alcohol consumption while taking Twynsta, as alcohol can lower blood pressure and increase the risk of dizziness or fainting. Always consult your healthcare provider for personalized advice.
Comprehensive Drug Guide
How Does Twynsta Work?
- Telmisartan: Blocks the action of angiotensin II, a hormone that causes blood vessels to constrict. By preventing this hormone from binding to its receptors, telmisartan allows blood vessels to relax, lowering blood pressure.
- Amlodipine: Inhibits the entry of calcium ions into vascular smooth muscle and heart muscle cells, which helps to relax the blood vessels and improve blood flow.
Common Dosages
- Telmisartan 40 mg / Amlodipine 5 mg
- Telmisartan 40 mg / Amlodipine 10 mg
- Telmisartan 80 mg / Amlodipine 5 mg
- Telmisartan 80 mg / Amlodipine 10 mg
The specific dose prescribed will depend on the patient's blood pressure goals and response to treatment.
Typical Dosing
- The typical starting dose is one tablet once daily. Dosage adjustments are made based on blood pressure response and individual tolerance.
- Twynsta can be taken with or without food, and it is generally recommended to take the medication at the same time each day to maintain consistent blood pressure control.
Typical Dosing
FDA Approved Indications
- Treatment of hypertension in adults, especially when a combination of telmisartan and amlodipine is needed to achieve adequate blood pressure control.
Who Shouldn't Take Twynsta?
- Known hypersensitivity to telmisartan, amlodipine, or any other component of the drug.
- Pregnancy: ARBs, including telmisartan, can cause harm or death to the developing fetus. Twynsta should not be used during pregnancy.
- Severe liver or kidney impairment without close monitoring by a healthcare provider.
Advice From The Pharmacist
- Take Twynsta as directed by your healthcare provider, typically once daily.
- If you miss a dose, take it as soon as you remember, but if it’s close to the time of your next dose, skip the missed dose. Do not take two doses at once.
- Avoid grapefruit and grapefruit juice while taking Twynsta, as it can increase the level of amlodipine in your blood, potentially leading to side effects.
- Keep a close check on your blood pressure while taking this medication, and report any significant changes to your healthcare provider.
- Do not stop taking Twynsta without consulting your doctor, even if you feel well. High blood pressure often has no symptoms.
Side Effects of Twynsta
Common Side Effects
- Dizziness
- Swelling (edema) in the legs or ankles
- Fatigue
- Flushing (warmth, redness, or tingly feeling)
- Low blood pressure (hypotension)
Uncommon/Severe Side Effects
- Fainting
- Chest pain or a significant increase in angina (chest pain) symptoms
- Allergic reactions (e.g., rash, swelling, difficulty breathing)
- Severe low blood pressure
Risks and Warnings of Twynsta
- Hypotension (Low Blood Pressure): Twynsta can cause a significant drop in blood pressure, particularly in patients who are volume-depleted (e.g., due to diuretics or dehydration). Symptoms of low blood pressure include dizziness or fainting.
- Heart Attack or Worsening Angina: Rarely, amlodipine can cause a worsening of chest pain or a heart attack in patients with severe heart disease.
- Kidney Function: Twynsta may affect kidney function, especially in individuals with pre-existing kidney conditions. Regular monitoring of kidney function is recommended.
- Pregnancy Warning: Twynsta should not be used during pregnancy due to the risk of fetal harm. If you become pregnant while taking Twynsta, contact your healthcare provider immediately.
Interactions with Twynsta
Common Drug Interactions
- Grapefruit juice: Avoid grapefruit products while taking Twynsta, as they can increase the concentration of amlodipine and the risk of side effects.
- NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen may reduce the effectiveness of Twynsta and increase the risk of kidney problems.
- Diuretics: If you are taking diuretics (water pills), your healthcare provider may need to adjust the dose to avoid excessive drops in blood pressure.
Alternatives to Twynsta
- Exforge: A combination of valsartan (ARB) and amlodipine (CCB) for the treatment of hypertension.
- Lotrel: A combination of benazepril (ACE inhibitor) and amlodipine for managing high blood pressure.
- Hyzaar: A combination of losartan (ARB) and hydrochlorothiazide (a diuretic) used for hypertension management.
- Diovan HCT: A combination of valsartan and hydrochlorothiazide for hypertension.
