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Trulance
Trulance (generic name: plecanatide) is a prescription medication used to treat adults with certain types of chronic constipation. It is specifically approved for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). Trulance works by stimulating fluid secretion in the intestines, which helps soften the stool and promote more regular bowel movements. It is a once-daily oral medication designed to improve symptoms like infrequent stools, hard stools, and straining during bowel movements.
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Frequently Asked Questions
How long does it take for Trulance to work?
Many patients start noticing improvements in constipation symptoms within the first week of taking Trulance, though results can vary.
Can I take Trulance with food?
Yes, Trulance can be taken with or without food. The timing of meals does not affect the efficacy of the medication.
What should I do if I miss a dose of Trulance?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at once.
Is Trulance safe for long-term use?
Trulance is generally considered safe for long-term use in managing chronic constipation or IBS-C. Your healthcare provider will monitor your condition to ensure its continued safety and effectiveness.
Can I use Trulance for occasional constipation?
Trulance is not typically prescribed for occasional constipation. It is intended for chronic conditions like CIC or IBS-C. Over-the-counter laxatives may be more appropriate for occasional constipation. Consult your healthcare provider for recommendations.
Comprehensive Drug Guide
How Does Trulance Work?
Trulance works by activating guanylate cyclase-C (GC-C) receptors in the lining of the intestines. This activation increases the production of cyclic guanosine monophosphate (cGMP), which stimulates the secretion of fluid into the intestines. The additional fluid helps soften stool and promote bowel movements. This action also helps reduce abdominal pain associated with constipation in patients with IBS-C.
Common Dosages
- 3 mg oral tablets, taken once daily.
Typical Dosing
- The recommended dose of Trulance is 3 mg once daily, with or without food.
- The tablet can be swallowed whole or crushed and mixed with water or applesauce if needed for patients who have difficulty swallowing.
Typical Dosing
FDA Approved Indications
- Chronic Idiopathic Constipation (CIC)
- Irritable Bowel Syndrome with Constipation (IBS-C)
Who Shouldn't Take Trulance?
- Known or suspected mechanical gastrointestinal obstruction.
- Children under 6 years of age due to the risk of severe dehydration, and it is not recommended for use in patients under 18 years old.
- History of hypersensitivity or allergy to plecanatide or any of its components.
Advice From The Pharmacist
- Take Trulance exactly as prescribed, once daily, at any time of day, with or without food.
- If you have trouble swallowing pills, you can crush the tablet and mix it with water or applesauce, but be sure to take it immediately.
- Trulance is not recommended for pediatric patients under 18 due to the risk of dehydration.
- Store the medication at room temperature and keep it out of reach of children.
Side Effects of Trulance
Common Side Effects
- Diarrhea (most common)
- Bloating or gas
- Nausea
- Abdominal pain
Uncommon/Severe Side Effects
- Severe diarrhea, which can lead to dehydration
- Allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Trulance
- Severe Diarrhea: Trulance can cause diarrhea, which may lead to dehydration, particularly in the first few weeks of treatment. If diarrhea is severe or persistent, contact your healthcare provider immediately and consider discontinuing the medication.
- Not for Pediatric Use: Trulance is contraindicated in children under 6 years old due to the risk of severe dehydration. It is not recommended for use in patients under 18.
- Hydration: Patients should stay well-hydrated while taking Trulance, particularly if diarrhea occurs, to avoid dehydration.
Interactions with Trulance
Common Drug Interactions
- No significant drug interactions have been identified with Trulance. However, always inform your healthcare provider of all medications, supplements, and over-the-counter products you are using to ensure safety.
Alternatives to Trulance
- Linzess (linaclotide): Another guanylate cyclase-C agonist used to treat IBS-C and CIC.
- Amitiza (lubiprostone): A medication that increases fluid secretion in the intestines, used for constipation.
- Motegrity (prucalopride): A selective serotonin 5-HT4 receptor agonist used to treat CIC.
- Over-the-counter laxatives: Short-term options for constipation relief, but not suitable for long-term use.
