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Lubiprostone
Lubiprostone is a chloride channel activator used to treat chronic constipation in adults, including chronic idiopathic constipation (CIC), irritable bowel syndrome with constipation (IBS-C) in women, and opioid-induced constipation (OIC) in adults with chronic, non-cancer pain. By increasing fluid secretion in the intestines, lubiprostone helps soften stool and stimulate bowel movements, making it easier to pass stool and relieve symptoms of constipation.
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Frequently Asked Questions
How long does it take for Lubiprostone to start working?
Lubiprostone may begin to improve bowel movements within 24 to 48 hours, but it may take longer for full relief of constipation symptoms. Continue taking the medication as prescribed for best results.
Can I take Lubiprostone for occasional constipation?
No, lubiprostone is intended for chronic constipation (long-term constipation) and is not recommended for occasional or short-term constipation. Speak to your healthcare provider about other options if you experience occasional constipation.
What should I do if I miss a dose of lubiprostone?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.
Can I take lubiprostone if I have diarrhea?
You should not take lubiprostone if you are experiencing severe diarrhea, as it may worsen your symptoms. Contact your healthcare provider if diarrhea becomes persistent or severe while taking lubiprostone.
Is lubiprostone safe for long-term use?
Yes, lubiprostone is approved for long-term use in treating chronic constipation. However, regular monitoring by your healthcare provider is important to ensure its continued effectiveness and to manage any side effects.
Comprehensive Drug Guide
How Does Lubiprostone Work?
Lubiprostone works by activating chloride channels in the lining of the intestines. This activation increases the secretion of chloride-rich fluid into the intestines, which helps to soften stools, improve bowel movements, and promote regularity. It also enhances the motility of the gastrointestinal tract, helping to relieve constipation by stimulating the passage of stool through the intestines.
Common Dosages
- 8 mcg capsule, typically used for IBS-C in women
- 24 mcg capsule, used for CIC and OIC in adults
Typical Dosing
- For chronic idiopathic constipation (CIC): The recommended dose is 24 mcg twice daily with food and water.
- For irritable bowel syndrome with constipation (IBS-C): The usual dose is 8 mcg twice daily with food and water.
- For opioid-induced constipation (OIC): The recommended dose is 24 mcg twice daily with food and water.
Typical Dosing
FDA Approved Indications
- Chronic idiopathic constipation (CIC) in adults
- Irritable bowel syndrome with constipation (IBS-C) in adult women
- Opioid-induced constipation (OIC) in adults with chronic, non-cancer pain
Who Shouldn't Take Lubiprostone?
- Known or suspected mechanical gastrointestinal obstruction.
- Severe diarrhea, as lubiprostone may worsen this condition.
- Known hypersensitivity to lubiprostone or any component of the formulation.
Advice From The Pharmacist
- Take lubiprostone with food and water to reduce the likelihood of nausea, one of the more common side effects.
- Do not crush, chew, or break the capsules. Swallow them whole.
- It may take a few days of regular use before you notice an improvement in constipation symptoms. Continue taking the medication as prescribed, even if symptoms do not improve right away.
- Stay well-hydrated while taking lubiprostone to support the increased fluid secretion in the intestines.
- If you experience severe diarrhea, abdominal pain, or difficulty breathing after taking lubiprostone, contact your healthcare provider immediately.
Side Effects of Lubiprostone
Common Side Effects
- Nausea
- Diarrhea
- Abdominal pain or bloating
- Headache
- Dizziness
Uncommon/Severe Side Effects
- Severe diarrhea or dehydration
- Difficulty breathing (may occur within an hour of the first dose but typically resolves within a few hours)
- Allergic reactions (such as rash, itching, or swelling)
Risks and Warnings of Lubiprostone
- Diarrhea: Lubiprostone may cause severe diarrhea in some patients. If diarrhea occurs, it is important to stay hydrated and consult your doctor. You may need to discontinue the medication if diarrhea is severe or persistent.
- Breathing Difficulties: Some patients may experience shortness of breath or chest tightness within the first hour of taking lubiprostone. This typically resolves on its own, but if breathing problems persist or worsen, seek medical attention.
- Pregnancy: The safety of lubiprostone during pregnancy has not been fully established. Women who are pregnant or planning to become pregnant should discuss the risks and benefits with their healthcare provider before starting this medication
Interactions with Lubiprostone
Common Drug Interactions
- Lubiprostone does not have significant known drug interactions but should be used cautiously in patients taking medications that may cause diarrhea or gastrointestinal issues. Always inform your healthcare provider about all the medications, supplements, and herbs you are taking.
Alternatives to Lubiprostone
- Linaclotide (Linzess): A medication used to treat IBS-C and chronic idiopathic constipation by increasing fluid secretion in the intestines.
- Plecanatide (Trulance): Another drug for chronic idiopathic constipation and IBS-C, which works similarly to lubiprostone by enhancing fluid secretion in the intestines.
- Prucalopride (Motegrity): A prokinetic agent used for chronic idiopathic constipation by stimulating gut motility.
- Over-the-counter laxatives (e.g., polyethylene glycol, senna): Common alternatives for short-term constipation relief.
