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Linzess
Linagliptin is a type of medication known as a DPP-4 inhibitor. It's used for managing type 2 diabetes, working by increasing the levels of natural substances that help to control blood sugars and decrease the amount of sugar your liver makes. Common side effects include stuffy or runny nose, sore throat, and diarrhea, but as always, your doctor will assess the benefits vs these potential issues.
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Frequently Asked Questions
Can Linagliptin cause weight gain?
Unlike some other diabetes medications, linagliptin is not typically associated with weight gain.
Can I drink alcohol while taking Linagliptin?
While it's not directly contraindicated, you should limit your alcohol intake. Alcohol can aggravate diabetes control and potentially raise the risk of developing lactic acidosis.
I missed a dose of Linagliptin, what should I do?
If it's near the time of your next dose, you should simply skip the missed dose. If it's still quite a bit of time until your next dose, take the missed one as soon as you remember it. Never double dose.
Will Linagliptin cause hypoglycemia (low blood sugar)?
In general, linagliptin alone doesn't cause hypoglycemia. However, it can occur if combined with other medications like sulfonylureas or insulin. Always consult with your healthcare provider.
Can Linagliptin cause pancreatitis?
Although rare, linagliptin can cause pancreatitis. If you feel severe and persistent stomach pain, often accompanied by vomiting, contact your healthcare provider immediately.
Comprehensive Drug Guide
How Does Linzess Work?
Linagliptin is an antidiabetic drug that works by inhibiting DPP-4, an enzyme that breaks down hormones called incretins. This boosts the levels of active incretins, enhancing the secretion of insulin (a hormone that reduces blood sugar), slowing gastric emptying, and reducing the amount of sugar produced by the liver during a meal.
What is Linzess Used For?
FDA indications: Linagliptin is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Off-label uses: While its primary role is in controlling type 2 diabetes, some studies suggest potential use in the treatment of polycystic ovary syndrome (PCOS), but this remains off-label.
Common Dosages
Tablets: 5mg
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Type 2 Diabetes Mellitus: 5mg once daily
Off-Label Uses
- For off-label uses:
- Polycystic ovary syndrome (PCOS): 5mg once daily
Who Shouldn't Take Linzess?
- People who are hypersensitive to linagliptin or any other ingredient in the product.
- Anyone with a history of pancreatitis.
- People with type 1 diabetes.
- Those with severe renal impairment, end-stage renal disease, or dialysis (its efficiency and safety in such conditions haven't been tested).
- Pregnant women or women planning pregnancy without a doctor's advice.
Advice From The Pharmacist
- Keep track of your blood sugar levels regularly.
- Ensure you're sticking to your prescribed diet and exercise regimen, along with this medication to control your blood sugar.
- Don't skip or double doses without discussing it with your healthcare provider.
- Avoid consuming alcohol which may dangerously lower blood sugar.
- Regularly monitor your kidney function.
- Inform your healthcare team about any new or worsening symptoms.
- Be aware that linagliptin can cause severe and disabling joint pain. Call your doctor right away if you have severe joint pain.
Side Effects of Linzess
Common Side Effects
- You may get a runny or stuffy nose and a sore throat.
- You might get an upset stomach or diarrhea.
Risks and Warnings of Linzess
- Consider potential warnings with linagliptin if you've had pancreatitis in the past, or if you have type 1 diabetes.
- Also, exercise caution if you have kidney issues in severe states including end-stage renal disease, or if you're on dialysis.
- Regarding pregnancy and breastfeeding, since there are no adequate studies done on pregnant women, it's advised to use linagliptin only if the potential benefit justifies the potential risk to the fetus.
Interactions with Linzess
Common Drug Interactions
- Insulin
- Metformin
- Glipizide
- Atorvastatin
- Simvastatin
Common Food Interactions
- No specific food interactions, but maintaining a balanced diet for diabetes is recommended.
- Limit alcohol intake.
Alternatives to Linzess
- Sitagliptin
- Saxagliptin
- Alogliptin
- Vildagliptin
