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Motegrity
Motegrity (generic name: prucalopride) is a medication used for the treatment of chronic idiopathic constipation in adults. It is a selective serotonin 5-HT4 receptor agonist that enhances gastrointestinal motility, helping to increase the frequency of bowel movements and improve overall bowel function.
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Frequently Asked Questions
How quickly does Motegrity work?
Many patients may begin to see improvements in bowel function within 1 to 3 days of starting treatment.
Can I take Motegrity with food?
Yes, Motegrity can be taken with or without food.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up doses.
Are there any dietary restrictions while using Motegrity?
There are no specific dietary restrictions while using Motegrity, but a balanced diet rich in fiber may enhance its effects.
Is Motegrity safe during pregnancy or breastfeeding?
Consult your healthcare provider if you are pregnant or breastfeeding to discuss the risks and benefits of using Motegrity during these periods.
Comprehensive Drug Guide
How Does Motegrity Work?
Prucalopride works by selectively stimulating serotonin receptors in the gastrointestinal tract, which enhances peristalsis (the wave-like muscle contractions that move food through the digestive system). This action promotes bowel movement and alleviates symptoms associated with constipation.
Common Dosages
- Tablets: 1 mg and 2 mg.
Typical Dosing
- The usual dose for adults is 2 mg taken orally once daily. If necessary, the dose may be reduced to 1 mg based on individual tolerability.
Typical Dosing
FDA Approved Indications
- Chronic Idiopathic Constipation: for the treatment of adults with this condition who have not responded adequately to other treatments.
Who Shouldn't Take Motegrity?
- Known hypersensitivity to prucalopride or any component of the formulation.
- Severe renal impairment or end-stage renal disease.
- History of bowel obstruction or inflammatory bowel disease.
Advice From The Pharmacist
- Take Motegrity exactly as prescribed, at the same time each day for the best results.
- Be patient, as it may take a few days to notice improvements in bowel function.
- Monitor for side effects, particularly gastrointestinal symptoms.
Side Effects of Motegrity
Common Side Effects
- Nausea
- Headache
- Abdominal pain
- Diarrhea
- Dizziness
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling)
- Symptoms of bowel obstruction.
Risks and Warnings of Motegrity
- Gastrointestinal Effects: Monitor for signs of worsening constipation or bowel obstruction; discontinue use if these occur.
- Renal Function: Use with caution in patients with renal impairment.
Interactions with Motegrity
Common Drug Interactions
- Other Medications: Inform your healthcare provider about all medications you are taking, especially those affecting gastrointestinal motility or serotonin levels.
Alternatives to Motegrity
- Other Laxatives: Such as polyethylene glycol or linaclotide for managing constipation.
- Dietary Changes: Increasing fiber and fluid intake may also help manage chronic constipation.
