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Amitiza
Amitiza (generic name: lubiprostone) is a chloride channel activator used to treat chronic idiopathic constipation (CIC), irritable bowel syndrome with constipation (IBS-C) in women, and opioid-induced constipation (OIC) in adults with chronic non-cancer pain. Amitiza works by increasing fluid secretion in the intestines, which softens stool and promotes bowel movements, making it easier for patients to manage constipation.
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Frequently Asked Questions
How long does it take for Amitiza to start working?
Some patients may notice relief from constipation within 24 to 48 hours of starting treatment with Amitiza, but full effects can take a few days.
Can Amitiza be used long-term?
Yes, Amitiza can be used for long-term management of constipation, but regular follow-ups with your healthcare provider are recommended to monitor your response to treatment.
What should I do if I miss a dose of Amitiza?
If you miss a dose, take it as soon as you remember, but skip the missed dose if it is close to the next scheduled dose. Do not take two doses at once.
Is Amitiza safe during pregnancy?
Amitiza is classified as a pregnancy category C drug, meaning that it should be used with caution during pregnancy. Always consult your healthcare provider before using Amitiza if you are pregnant or planning to become pregnant.
Can Amitiza be taken with other medications for IBS?
Amitiza can be combined with other medications, but it is important to discuss any combinations with your healthcare provider to avoid potential interactions and side effects.
Comprehensive Drug Guide
How Does Amitiza Work?
Amitiza works by activating chloride channels in the intestinal lining, which increases the secretion of chloride-rich fluid into the intestines. This additional fluid helps soften stool and stimulate bowel movements, alleviating the symptoms of constipation. Unlike some other constipation treatments, Amitiza does not affect the movement of the intestines (peristalsis) directly but rather encourages the natural process of bowel function.
Common Dosages
- Capsules: 8 mcg for IBS-C and 24 mcg for CIC and OIC
Typical Dosing
- For chronic idiopathic constipation (CIC) and opioid-induced constipation (OIC): The typical dose is 24 mcg taken twice daily with food and water.
- For irritable bowel syndrome with constipation (IBS-C): The usual dose is 8 mcg taken twice daily with food and water.
Typical Dosing
FDA Approved Indications
- Chronic idiopathic constipation (CIC) in adults
- Irritable bowel syndrome with constipation (IBS-C) in women aged 18 years and older
- Opioid-induced constipation (OIC) in adults with chronic non-cancer pain
Who Shouldn't Take Amitiza?
- Known hypersensitivity to lubiprostone or any other ingredient in the formulation.
- Bowel obstruction or a history of mechanical gastrointestinal obstruction, as it may worsen the condition.
Advice From The Pharmacist
- Take Amitiza with food and water to reduce the risk of nausea, which is a common side effect.
- If you experience severe diarrhea, stop taking Amitiza and consult your healthcare provider, as this may indicate that the medication is working too effectively.
- Stay hydrated to support the medication’s mechanism of action and avoid potential dehydration.
Side Effects of Amitiza
Common Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Bloating
- Headache
Uncommon/Severe Side Effects
- Severe diarrhea
- Difficulty breathing (especially within an hour of taking the medication)
- Chest tightness or discomfort
Risks and Warnings of Amitiza
- Breathing Difficulties: Some patients may experience shortness of breath or chest discomfort shortly after taking Amitiza, which generally resolves within a few hours. Contact your healthcare provider if this occurs.
- Diarrhea: Amitiza can cause severe diarrhea in some patients. If this happens, discontinue use and seek medical advice to avoid dehydration or other complications.
- Pregnancy: Amitiza should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Consult your healthcare provider before using Amitiza if you are pregnant or planning to become pregnant.
Interactions with Amitiza
Common Drug Interactions
- Other constipation medications: Combining Amitiza with other laxatives or stool softeners may increase the risk of diarrhea or gastrointestinal discomfort.
- Opioids: While Amitiza is used to treat opioid-induced constipation, taking it alongside opioids can sometimes require careful dosing adjustments to manage constipation effectively.
Alternatives to Amitiza
- Linzess (linaclotide): Another medication for chronic idiopathic constipation and IBS-C, but it works by increasing the secretion of chloride and bicarbonate into the intestines.
- Movantik (naloxegol): Used specifically to treat opioid-induced constipation by targeting the opioid receptors in the gut.
- MiraLAX (polyethylene glycol 3350): An over-the-counter osmotic laxative that softens stool by drawing water into the bowel.
