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Trospium Chloride ER
Trospium Chloride ER is the extended-release version of Trospium Chloride, a medication used to treat symptoms of overactive bladder (OAB), including urinary urgency, frequency, and urge incontinence. It belongs to the anticholinergic drug class, which works by relaxing the bladder muscles, thereby helping to control the symptoms of OAB. Trospium Chloride ER offers the benefit of once-daily dosing, providing long-lasting symptom relief throughout the day.
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Frequently Asked Questions
How long does it take for Trospium Chloride ER to work?
Most patients begin to notice an improvement in overactive bladder symptoms within the first 1 to 2 weeks of treatment, with full effects typically seen after 4 to 8 weeks.
Can I take Trospium Chloride ER with food?
It is recommended to take Trospium Chloride ER on an empty stomach, 1 hour before meals, to ensure proper absorption. Taking it with food may reduce its effectiveness.
What should I do if I miss a dose of Trospium Chloride ER?
If you miss a dose, take it as soon as you remember unless it is close to the time of your next dose. Do not take two doses at once to make up for a missed dose.
Does Trospium Chloride ER cause weight gain?
Weight gain is not a common side effect of Trospium Chloride ER. However, some patients may experience fluid retention or other changes. Discuss any concerns with your healthcare provider.
Can I drink alcohol while taking Trospium Chloride ER?
It is best to avoid alcohol while taking Trospium Chloride ER, as alcohol can increase the risk of side effects like dizziness and drowsiness.
Comprehensive Drug Guide
How Does Trospium Chloride ER Work?
Trospium Chloride ER works by blocking muscarinic receptors in the bladder muscle. This reduces the effect of the neurotransmitter acetylcholine, which stimulates bladder contractions. By inhibiting acetylcholine's action, the medication helps to prevent involuntary bladder contractions, thus reducing the symptoms of overactive bladder, such as urinary urgency and frequency.
Common Dosages
- 60 mg extended-release capsules
Typical Dosing
- The usual recommended dose of Trospium Chloride ER is 60 mg taken once daily, preferably on an empty stomach at least one hour before meals or on an empty stomach.
Typical Dosing
FDA Approved Indications
- Overactive bladder (OAB) with symptoms of urinary frequency, urgency, and urge incontinence
Who Shouldn't Take Trospium Chloride ER?
- Known hypersensitivity to Trospium Chloride or any of its components
- Urinary retention
- Gastric retention or severe gastrointestinal motility disorders
- Narrow-angle glaucoma (untreated)
Advice From The Pharmacist
- Take Trospium Chloride ER once daily with water, 1 hour before eating, to ensure the best absorption of the medication.
- Swallow the capsule whole; do not crush, chew, or open the capsule, as it may alter the extended-release mechanism.
- Stay well-hydrated while using this medication, as it may cause dry mouth or constipation.
- Trospium may cause drowsiness or blurred vision, so avoid driving or operating heavy machinery until you know how the medication affects you.
- If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses to make up for a missed dose.
Side Effects of Trospium Chloride ER
Common Side Effects
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Urinary retention
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Confusion or hallucinations (especially in elderly patients)
Risks and Warnings of Trospium Chloride ER
- Urinary Retention: Trospium Chloride ER may cause difficulty in completely emptying the bladder. Contact your doctor if you have trouble urinating.
- Heatstroke Risk: Anticholinergics like Trospium Chloride ER may decrease your ability to sweat, which can increase the risk of heatstroke. Stay hydrated and avoid excessive heat.
- Cognitive Effects: Elderly patients may be more prone to side effects such as confusion, dizziness, or hallucinations. Careful monitoring is advised, especially in elderly or cognitively impaired patients.
Interactions with Trospium Chloride ER
Common Drug Interactions
- Other Anticholinergics: Using other anticholinergic medications alongside Trospium Chloride ER may increase the risk of side effects like dry mouth, constipation, or blurred vision.
- Alcohol: Alcohol can enhance the drowsiness and dizziness caused by Trospium Chloride ER. Avoid consuming alcohol while using this medication.
- Kidney function medications: Trospium is cleared primarily by the kidneys, so medications that affect kidney function may impact how your body processes Trospium Chloride ER.
Alternatives to Trospium Chloride ER
- Oxybutynin ER (Ditropan XL): Another anticholinergic medication used to manage overactive bladder symptoms with extended-release dosing.
- Tolterodine (Detrol LA): An alternative anticholinergic medication used to reduce urinary frequency and urgency.
- Mirabegron (Myrbetriq): A beta-3 adrenergic agonist used for treating overactive bladder, offering an alternative for those who cannot tolerate anticholinergics.
- Solifenacin (Vesicare): Another anticholinergic medication commonly used to treat overactive bladder symptoms.
