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Detrol LA
Detrol LA (tolterodine tartrate) is an extended-release antimuscarinic medication used to treat overactive bladder (OAB) symptoms, including urinary frequency, urgency, and urge incontinence. It works by relaxing the muscles in the bladder, allowing it to hold more urine and reducing the frequency of urination. Detrol LA provides long-lasting relief from OAB symptoms with once-daily dosing.
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Frequently Asked Questions
How long does it take for Detrol LA to start working?
Some patients may begin to notice improvements in bladder control within the first week, but it may take 4 to 8 weeks for the full benefits of Detrol LA to become noticeable.
Can Detrol LA cause weight gain?
Weight gain is not a common side effect of Detrol LA. If you experience significant weight changes, consult your healthcare provider.
What should I do if I miss a dose of Detrol LA?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Can Detrol LA be taken with food?
Yes, Detrol LA can be taken with or without food. Swallow the capsule whole without crushing or chewing it.
Is Detrol LA safe for long-term use?
Yes, Detrol LA is generally safe for long-term use when taken as prescribed. However, regular follow-up appointments with your healthcare provider are recommended to monitor for any side effects or changes in bladder function.
Comprehensive Drug Guide
How Does Detrol LA Work?
Detrol LA works by blocking muscarinic receptors in the bladder, which reduces the involuntary contractions of the bladder muscles. This allows the bladder to store more urine and reduces the urgent need to urinate.
What is Detrol LA Used For?
Treatment of overactive bladder (OAB) with symptoms of urgency, frequency, and urge incontinence
Common Dosages
Detrol LA is available in the following strengths:
- 2 mg extended-release capsules
- 4 mg extended-release capsules
Typical Dosing
FDA Approved Indications
The typical starting dose for adults is 4 mg once daily. Based on the patient's response and tolerability, the dose may be reduced to 2 mg once daily.
Who Shouldn't Take Detrol LA?
Detrol LA should not be used in individuals with:
- Urinary retention
- Gastric retention (e.g., severe digestive disorders)
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to tolterodine or any ingredients in the formulation
Advice From The Pharmacist
- Take Detrol LA at the same time every day, with or without food. Swallow the capsule whole and do not crush or chew it.
- If you experience dry mouth, chewing sugarless gum or sucking on sugarless candy may help.
- Drink plenty of water and maintain hydration, as antimuscarinics can lead to dry mouth and decreased sweating.
- If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. Do not double the dose.
Side Effects of Detrol LA
Common Side Effects
- Dry mouth
- Headache
- Constipation
- Drowsiness
- Blurred vision
Uncommon/Severe Side Effects
- Urinary retention
- Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
- Confusion or memory problems
Risks and Warnings of Detrol LA
Cognitive Impairment: Detrol LA may cause drowsiness, confusion, or memory problems in some patients. Use caution when driving or operating machinery.
Urinary Retention: In some patients, especially those with pre-existing urinary issues, Detrol LA can worsen urinary retention. Patients should be monitored for difficulty urinating.
Increased Glaucoma Risk: Detrol LA can worsen narrow-angle glaucoma. Patients with glaucoma should be closely monitored, and the medication should be avoided in uncontrolled cases.
Interactions with Detrol LA
Common Drug Interactions
- Other anticholinergic medications: Using Detrol LA with other anticholinergics can increase the risk of side effects such as dry mouth, constipation, and blurred vision.
- Ketoconazole or other CYP3A4 inhibitors: These medications can increase the blood levels of tolterodine, leading to an increased risk of side effects.
- Medications that slow gastric motility: Combining Detrol LA with other medications that slow digestion can increase the risk of gastric retention
Alternatives to Detrol LA
- Oxybutynin (Ditropan XL): Another antimuscarinic medication used for the treatment of overactive bladder.
- Solifenacin (Vesicare): A long-acting antimuscarinic for the treatment of overactive bladder.
- Myrbetriq (mirabegron): A beta-3 adrenergic agonist used to treat OAB by relaxing the bladder without using anticholinergic effects.
- Trospium (Sanctura XR): An anticholinergic medication with similar effects used to treat OAB.
