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Tribenzor
Tribenzor is a combination medication used to treat high blood pressure (hypertension). It contains three active ingredients: olmesartan medoxomil, an angiotensin II receptor blocker (ARB); amlodipine, a calcium channel blocker; and hydrochlorothiazide, a thiazide diuretic. Together, these medications work to lower blood pressure by relaxing blood vessels, reducing fluid retention, and blocking the effects of angiotensin II, which constricts blood vessels. Lowering blood pressure helps to prevent strokes, heart attacks, and kidney problems.
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Frequently Asked Questions
How long does it take for Tribenzor to lower blood pressure?
You may start to see a reduction in blood pressure within a few days, but it may take 2 to 4 weeks for the full effect.
Can I stop taking Tribenzor if my blood pressure is normal?
No, you should not stop taking Tribenzor without consulting your healthcare provider, even if your blood pressure becomes normal. Stopping the medication abruptly may cause your blood pressure to rise again.
Can I take Tribenzor with food?
Yes, Tribenzor can be taken with or without food. However, it is important to take it consistently at the same time each day.
Does Tribenzor cause frequent urination?
Yes, the hydrochlorothiazide in Tribenzor is a diuretic and may cause you to urinate more frequently. This is a normal effect of the medication.
What should I do if I miss a dose?
If you miss a dose of Tribenzor, take it as soon as you remember unless it is close to your next scheduled dose. Do not take two doses at the same time to make up for a missed dose.
Comprehensive Drug Guide
How Does Tribenzor Work?
- Olmesartan blocks the angiotensin II receptor, preventing blood vessel constriction and reducing blood pressure.
- Amlodipine relaxes the blood vessels by inhibiting the influx of calcium into the blood vessel walls, leading to vasodilation.
- Hydrochlorothiazide helps the kidneys remove excess salt and water from the body, reducing fluid retention and lowering blood pressure.
Common Dosages
- 20 mg olmesartan / 5 mg amlodipine / 12.5 mg hydrochlorothiazide
- 40 mg olmesartan / 5 mg amlodipine / 12.5 mg hydrochlorothiazide
- 40 mg olmesartan / 10 mg amlodipine / 25 mg hydrochlorothiazide
Typical Dosing
- The typical starting dose for adults is one tablet once daily, with the strength of the tablet chosen based on individual patient needs. Doses may be adjusted by the healthcare provider depending on blood pressure response and tolerability.
- Tribenzor should be taken at the same time each day, with or without food.
Typical Dosing
FDA Approved Indications
- The treatment of hypertension (high blood pressure) in patients who require multiple medications to control their blood pressure.
Who Shouldn't Take Tribenzor?
- Anuria (inability to urinate)
- Known hypersensitivity to olmesartan, amlodipine, hydrochlorothiazide, or any of the components
- Severe liver disease or kidney disease
- Pregnancy: Use during pregnancy can cause harm or death to the fetus, particularly in the second and third trimesters.
Advice From The Pharmacist
- Take Tribenzor once daily, at the same time each day. You can take it with or without food, but consistency is key.
- Stay hydrated and follow your doctor's dietary recommendations, especially if you're advised to reduce salt intake.
- If you miss a dose, take it as soon as you remember unless it is close to your next dose. Do not take two doses at once.
- Monitor your blood pressure regularly and keep a log to discuss with your healthcare provider.
- Avoid over-the-counter NSAIDs (such as ibuprofen), as they may reduce the effectiveness of this medication in controlling blood pressure.
Side Effects of Tribenzor
Common Side Effects
- Dizziness or lightheadedness, especially when standing up
- Swelling in the legs, ankles, or feet (due to amlodipine)
- Fatigue
- Headache
- Nausea
Uncommon/Severe Side Effects
- Low blood pressure (hypotension) with symptoms like dizziness or fainting
- Kidney problems, indicated by changes in urination
- Electrolyte imbalances (low potassium or sodium) with symptoms like muscle cramps or weakness
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Tribenzor
- Pregnancy Risk: Tribenzor should not be used during pregnancy as it can cause harm to the fetus. If you become pregnant while taking this medication, contact your healthcare provider immediately.
- Low Blood Pressure: Tribenzor may cause low blood pressure, especially when standing up (postural hypotension). Move slowly when changing positions to avoid dizziness or fainting.
- Kidney Function: Tribenzor can affect kidney function, particularly in patients with pre-existing kidney issues. Your healthcare provider may monitor kidney function with blood tests.
- Electrolyte Imbalance: Hydrochlorothiazide can cause imbalances in potassium, sodium, and other electrolytes, which may need to be monitored during treatment.
Interactions with Tribenzor
Common Drug Interactions
- NSAIDs (e.g., ibuprofen): May reduce the effectiveness of Tribenzor in controlling blood pressure and increase the risk of kidney problems.
- Potassium supplements or salt substitutes: Hydrochlorothiazide can lower potassium levels, but olmesartan can increase potassium. Consult your doctor before using supplements to avoid high potassium levels.
- ACE inhibitors or ARBs: Using these medications together with Tribenzor can increase the risk of kidney problems and hyperkalemia (high potassium levels).
Alternatives to Tribenzor
- Losartan-HCTZ (Hyzaar): A combination of an ARB and diuretic used for hypertension.
- Valsartan-Amlodipine-HCTZ (Exforge HCT): Another three-drug combination used for high blood pressure.
- Lisinopril-HCTZ (Zestoretic): A combination of an ACE inhibitor and thiazide diuretic used to treat high blood pressure.
