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Triazolam
Triazolam is a benzodiazepine used to treat insomnia on a short-term basis. It helps people fall asleep faster and stay asleep for a longer period by promoting relaxation and reducing activity in the central nervous system (CNS). Triazolam is typically prescribed for short-term use (7 to 10 days) due to its potential for dependence and tolerance.
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Frequently Asked Questions
How long does it take for triazolam to work?
Triazolam typically works within 15 to 30 minutes of taking it, making it effective for helping you fall asleep quickly.
Can I use triazolam for long-term insomnia treatment?
No, triazolam is intended for short-term use (7 to 10 days). Long-term use increases the risk of dependence, tolerance, and withdrawal symptoms.
What should I do if I miss a dose?
If you miss a dose and still need to sleep, take the missed dose as soon as you remember, but only if you have enough time to get 7 to 8 hours of sleep. Do not take extra doses to make up for a missed one.
Can triazolam cause memory problems?
Yes, triazolam can cause anterograde amnesia, meaning it can affect your ability to form new memories after taking the medication, particularly if you do not get enough sleep after taking it.
Is triazolam safe for older adults?
Older adults may be more sensitive to the effects of triazolam, including next-day drowsiness and falls. Lower doses and close monitoring are recommended for older patients.
Comprehensive Drug Guide
How Does Triazolam Work?
Triazolam works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits activity in the brain. By increasing GABA activity, triazolam produces a calming effect on the CNS, helping individuals fall asleep faster and remain asleep longer. Its short duration of action makes it particularly effective for sleep initiation rather than long-term sleep maintenance.
Common Dosages
- 0.125 mg tablets
- 0.25 mg tablets
Typical Dosing
- The typical starting dose for adults is 0.125 mg to 0.25 mg taken once before bedtime.
- Dosage may be adjusted based on individual response, but it is generally recommended to use the lowest effective dose for the shortest duration possible.
- Triazolam should not be used for more than 7 to 10 consecutive days without reevaluation by a healthcare provider.
Typical Dosing
FDA Approved Indications
- The short-term treatment of insomnia, particularly for individuals who have difficulty falling asleep.
Who Shouldn't Take Triazolam?
- Severe liver disease
- Known hypersensitivity to triazolam or other benzodiazepines
- Sleep apnea or other serious breathing disorders
- A history of substance abuse
Advice From The Pharmacist
- Take triazolam right before bedtime to help you fall asleep faster. Ensure you can get at least 7 to 8 hours of sleep after taking the medication to avoid next-day drowsiness.
- Avoid drinking alcohol or using other sedatives while taking triazolam, as this can increase the risk of serious side effects like excessive drowsiness or difficulty breathing.
- Triazolam is intended for short-term use only. Using it for longer periods can lead to dependence or tolerance.
- Do not suddenly stop taking triazolam if you have been using it for a prolonged period, as this can cause withdrawal symptoms. Consult your doctor about gradually reducing the dose.
Side Effects of Triazolam
Common Side Effects
- Drowsiness
- Dizziness
- Headache
- Coordination problems
- Dry mouth
Uncommon/Severe Side Effects
- Memory problems (anterograde amnesia)
- Confusion or abnormal thoughts and behavior
- Sleepwalking or performing activities while asleep (e.g., eating, driving)
- Allergic reactions (rash, swelling, difficulty breathing)
- Dependence and withdrawal symptoms with long-term use
Risks and Warnings of Triazolam
- Dependence and Abuse: Triazolam can be habit-forming, and there is a risk of dependence with prolonged use. It should only be used for short-term treatment of insomnia.
- Withdrawal Symptoms: Abruptly stopping triazolam after prolonged use can cause withdrawal symptoms, including anxiety, irritability, and sleep disturbances. Tapering off the medication under a doctor’s supervision is recommended.
- CNS Depression: Combining triazolam with other CNS depressants, including alcohol, opioids, or other sedatives, can result in dangerous side effects such as severe drowsiness, respiratory depression, or coma.
- Next-Day Impairment: Some individuals may experience next-day drowsiness or impaired alertness. Avoid driving or operating heavy machinery until you know how the medication affects you.
Interactions with Triazolam
Common Drug Interactions
- Alcohol: Increases the sedative effects of triazolam and the risk of serious side effects like respiratory depression.
- Opioids: Combining triazolam with opioid medications increases the risk of respiratory depression, sedation, and overdose.
- Antifungals (e.g., ketoconazole): Can increase the blood levels of triazolam, leading to enhanced sedative effects.
- Grapefruit juice: May increase the blood levels of triazolam and should be avoided while taking this medication.
Alternatives to Triazolam
- Temazepam (Restoril): Another benzodiazepine used for short-term insomnia treatment, with a longer duration of action.
- Zolpidem (Ambien): A non-benzodiazepine sedative-hypnotic used for short-term treatment of insomnia.
- Eszopiclone (Lunesta): A non-benzodiazepine hypnotic used to treat insomnia for both sleep initiation and sleep maintenance.
- Melatonin: A non-prescription alternative for sleep difficulties, especially for individuals who prefer natural remedies.
