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Temazepam
Temazepam is a prescription benzodiazepine medication used to treat insomnia (difficulty falling or staying asleep). It works by enhancing the activity of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which produces a calming effect and helps patients fall asleep faster and stay asleep longer. Temazepam is typically used for short-term treatment of sleep disorders, as it can become habit-forming if used for an extended period.
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Frequently Asked Questions
How long does it take for temazepam to start working?
Temazepam typically begins to work within 30 minutes to 1 hour after taking it. It is best taken just before going to bed.
Can I take temazepam every night?
Temazepam is intended for short-term use only, generally for 7 to 10 days. Long-term use can lead to dependence, and it should not be taken every night unless directed by your healthcare provider.
What should I do if I miss a dose of temazepam?
If you forget to take temazepam and it is close to bedtime, take it as soon as you remember. However, if you are not planning to sleep for at least 7 to 8 hours, it’s best to skip the dose to avoid next-day drowsiness.
Is temazepam addictive?
Yes, temazepam can be habit-forming, particularly with prolonged use. It is important to use it exactly as prescribed and not to take it for longer than recommended.
Can I stop taking temazepam suddenly?
No, you should not stop temazepam abruptly, especially if you have been taking it for a long period. Stopping suddenly can lead to withdrawal symptoms, including anxiety, insomnia, seizures, and tremors. Gradual tapering under medical supervision is recommended.
Comprehensive Drug Guide
How Does Temazepam Work?
Temazepam works by increasing the activity of GABA, a neurotransmitter that inhibits brain activity, thereby producing sedative and hypnotic effects. This helps induce sleep and prolong sleep duration by reducing overactivity in the brain that contributes to insomnia.
Common Dosages
- 7.5 mg
- 15 mg
- 22.5 mg
- 30 mg
Typical Dosing
- Adults: The usual dose of temazepam for insomnia is 15 mg to 30 mg, taken once before bedtime. Lower doses may be prescribed in elderly patients or those with liver impairment.
- Temazepam is intended for short-term use only, typically for 7 to 10 days.
Typical Dosing
FDA Approved Indications
- Short-term treatment of insomnia (generally used for 7-10 days) in adults who have difficulty falling asleep or staying asleep.
Who Shouldn't Take Temazepam?
- Known hypersensitivity to temazepam or other benzodiazepines
- Severe respiratory insufficiency or sleep apnea syndrome
- Myasthenia gravis (a condition that causes muscle weakness)
- Pregnancy, due to the risk of harm to the fetus (it is categorized as a pregnancy category X drug)
Advice From The Pharmacist
- Take Temazepam just before bedtime, as it works quickly to induce sleep.
- Do not take temazepam if you do not plan to sleep for at least 7 to 8 hours, as you may experience drowsiness the next day.
- Avoid alcohol and other central nervous system depressants while taking temazepam, as this can enhance its sedative effects and increase the risk of side effects.
- Temazepam can be habit-forming. It should only be used for short-term treatment, and you should follow your doctor's instructions carefully regarding dosage and duration.
- Do not stop taking temazepam abruptly, especially if you have been using it for an extended period, as this can lead to withdrawal symptoms. Gradual dose reduction is recommended under medical supervision.
Side Effects of Temazepam
Common Side Effects
- Drowsiness or dizziness the next day
- Headache
- Fatigue
- Nausea
- Blurred vision
Uncommon/Severe Side Effects
- Severe allergic reactions (rash, itching, swelling of the face, tongue, or throat)
- Sleep behaviors: Complex sleep-related behaviors like sleepwalking, sleep driving, or making phone calls while not fully awake
- Memory problems (anterograde amnesia)
- Depression or mood changes
Risks and Warnings of Temazepam
- Risk of Dependence: Temazepam can be habit-forming, especially with prolonged use or in higher doses. Use should be limited to short-term treatment, and the patient should be monitored for signs of dependence.
- Withdrawal Symptoms: Abrupt discontinuation can result in withdrawal symptoms, including anxiety, tremors, and seizures.
- Impaired Coordination: Temazepam may cause impaired motor skills and coordination, increasing the risk of falls or accidents, especially in older adults.
- Risk in Pregnancy: Temazepam should not be used during pregnancy as it can cause harm to the developing fetus, including birth defects or withdrawal symptoms in newborns
Interactions with Temazepam
Common Drug Interactions
- Alcohol: Combining alcohol with temazepam can increase sedation, dizziness, and the risk of severe side effects like respiratory depression.
- Opioids and other CNS depressants: Using temazepam with other medications that depress the central nervous system (such as opioids, antipsychotics, or barbiturates) can lead to serious side effects, including profound sedation, respiratory depression, coma, or death.
- Antihistamines and sedative drugs: These can increase the sedative effects of temazepam and lead to excessive drowsiness.
Alternatives to Temazepam
- Zolpidem (Ambien): A non-benzodiazepine sedative-hypnotic used for short-term treatment of insomnia.
- Eszopiclone (Lunesta): Another non-benzodiazepine option for treating insomnia.
- Trazodone: An antidepressant that is sometimes used off-label for its sedative properties in treating insomnia.
- Melatonin supplements: A natural supplement that can help regulate the sleep-wake cycle in individuals with mild sleep disturbances.