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Ambien
Ambien, the brand name for zolpidem, is a prescription medication used to treat insomnia. It belongs to a class of drugs known as sedative-hypnotics and is typically prescribed for short-term use to help individuals fall asleep more easily and stay asleep through the night. Ambien works by slowing down brain activity, allowing individuals with sleep difficulties to get a more restful night’s sleep. It is available in both immediate-release and extended-release (Ambien CR) forms.
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Frequently Asked Questions
What should I do if I miss a dose of Ambien?
If you forget to take Ambien before bedtime, skip the dose. Do not take it during the night, as it may affect your ability to wake up in the morning.
Can I take Ambien with food?
It is best to take Ambien on an empty stomach, as food can delay its absorption and reduce its effectiveness.
How long does it take for Ambien to work?
Ambien works quickly, typically within 15-30 minutes, so it should be taken right before bedtime.
Is Ambien addictive?
Ambien has the potential for dependence and should only be used for the short-term treatment of insomnia. It is important to follow your doctor’s instructions and avoid using it for extended periods.
Can I stop taking Ambien suddenly?
Do not stop taking Ambien suddenly without consulting your doctor, as this can lead to withdrawal symptoms. Your doctor may recommend tapering the dose gradually to avoid these effects.
Comprehensive Drug Guide
How Does Ambien Work?
Ambien works by enhancing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that helps promote sleep by inhibiting certain brain activities. By boosting GABA’s effects, Ambien induces a calming and sedative effect, making it easier for individuals to fall asleep and stay asleep. The immediate-release form helps people fall asleep faster, while the extended-release (Ambien CR) formulation is designed to help people stay asleep throughout the night.
Common Dosages
- Tablets: Available in strengths of 5 mg and 10 mg.
- Extended-release tablets: Available in 6.25 mg and 12.5 mg formulations.
Typical Dosing
- For adults: The usual recommended dose is 10 mg taken immediately before bedtime. For those with a higher risk of side effects (e.g., elderly patients), a starting dose of 5 mg is recommended.
- For extended-release: The dosage may be 6.25 mg for women or elderly patients, and 12.5 mg for men.
Typical Dosing
FDA Approved Indications
- Short-term treatment of insomnia characterized by difficulty falling asleep or staying asleep.
Who Shouldn't Take Ambien?
- Known hypersensitivity or allergy to zolpidem or any ingredients in Ambien.
- Severe liver impairment, as it can increase the risk of side effects.
- History of complex sleep behaviors, such as sleepwalking, sleep-driving, or other activities while not fully awake.
Advice From The Pharmacist
Take Ambien right before bed, as it works quickly, and you should be prepared to sleep for at least 7-8 hours. Do not take it if you are unable to get a full night's rest, as this may increase the risk of next-day drowsiness. Avoid consuming alcohol or other sedatives while taking Ambien, as this can increase the risk of dangerous side effects. It is important to use Ambien for the short-term management of insomnia, as long-term use can lead to dependence. Do not suddenly stop taking Ambien without consulting your doctor, as this can lead to withdrawal symptoms.
Side Effects of Ambien
Common Side Effects
- Drowsiness or dizziness
- Headache
- Nausea or upset stomach
- Fatigue or feeling "hungover" the next day (especially if taken without a full night of sleep)
Uncommon/Severe Side Effects
- Complex sleep behaviors, such as sleepwalking, sleep-driving, or other activities while not fully awake
- Allergic reactions, such as swelling of the face, lips, or throat
- Abnormal thoughts or behaviors, such as agitation, confusion, or hallucinations
- Memory problems or difficulty concentrating
Risks and Warnings of Ambien
- Ambien can cause complex sleep behaviors, such as sleepwalking or sleep-driving, which may occur without the individual being fully awake.
- These behaviors can be dangerous, so discontinue Ambien if they occur and contact your healthcare provider.
- Additionally, Ambien can cause next-day drowsiness, particularly if taken with less than a full night of sleep or if taken in higher doses.
- Ambien has the potential for abuse and dependence, so it should be used for the shortest duration possible.
- Avoid alcohol and other sedative medications while using Ambien, as they can increase the risk of serious side effects.
Interactions with Ambien
Common Drug Interactions
- Alcohol, which increases the risk of dangerous side effects like drowsiness and impaired coordination.
- CNS depressants, such as benzodiazepines, opioids, or barbiturates, which can increase the sedative effects and risk of respiratory depression.
- Antidepressants, which may increase the risk of next-day drowsiness or other side effects.
Alternatives to Ambien
- Lunesta (eszopiclone) – another sedative-hypnotic
- Sonata (zaleplon) – a short-acting sleep aid
- Trazodone – an antidepressant often prescribed off-label for insomnia
- Melatonin – an over-the-counter supplement for sleep
- Cognitive Behavioral Therapy for Insomnia (CBT-I) – a non-drug treatment for chronic insomnia
