NiHowdy > Drug Classes > GLP-1 Receptor Agonists

Browse Medications by Drug Class: GLP-1 Receptor Agonists

Written by Amar Lunagaria

Pharm.D • NiHowdy Founder

Reviewed by James Wong

Pharm.D • NiHowdy Founder

Published Jan 15, 2025

Fact checked

What are GLP-1 Receptor Agonists?

GLP-1 receptor agonists are medications that mimic the action of glucagon-like peptide-1 (GLP-1), a hormone involved in regulating blood sugar levels. These medications enhance insulin secretion, suppress glucagon release, and slow gastric emptying, leading to improved glycemic control and weight loss. GLP-1 receptor agonists are primarily used to treat type 2 diabetes but are also effective for weight management in some cases. A unique characteristic of these medications is their ability to simultaneously improve blood sugar control and promote weight loss, addressing two key challenges in diabetes management. NiHowdy ensures affordable access to GLP-1 receptor agonists, empowering patients to take control of their health.

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List of drugs in GLP-1 Receptor Agonists

Drug Name	More Information	NiHowdy Prices & Bitcoin Rebate

Adlyxin	Adlyxin Information	Adlyxin Pricing
Bydureon BCise	Bydureon BCise Information	Bydureon BCise Pricing
Byetta 10 MCG Pen	Byetta 10 MCG Pen Information	Byetta 10 MCG Pen Pricing
Byetta 5 MCG Pen	Byetta 5 MCG Pen Information	Byetta 5 MCG Pen Pricing
Mounjaro	Mounjaro Information	Mounjaro Pricing
Ozempic	Ozempic Information	Ozempic Pricing
Rybelsus	Rybelsus Information	Rybelsus Pricing
Saxenda	Saxenda Information	Saxenda Pricing
Trulicity	Trulicity Information	Trulicity Pricing
Victoza	Victoza Information	Victoza Pricing
Wegovy	Wegovy Information	Wegovy Pricing

Brief history about GLP-1 Receptor Agonists?

GLP-1 receptor agonists were introduced in the early 2000s as a novel class of medications for managing type 2 diabetes. Exenatide, the first GLP-1 receptor agonist, was derived from a compound found in the saliva of the Gila monster lizard. Since then, several other GLP-1 receptor agonists, such as liraglutide, dulaglutide, and semaglutide, have been developed with improved efficacy and longer durations of action. These medications have revolutionized diabetes care by offering glycemic control and weight loss benefits in a single therapy. NiHowdy simplifies access to these innovative treatments, ensuring affordability for patients managing diabetes and related conditions.

How do GLP-1 Receptor Agonists work?

GLP-1 receptor agonists work by activating GLP-1 receptors in the pancreas, brain, and gastrointestinal tract. This activation enhances insulin secretion in response to meals, suppresses glucagon release, and slows gastric emptying. By delaying stomach emptying, these medications reduce appetite and promote satiety, leading to weight loss. In the brain, GLP-1 receptor agonists influence appetite-regulating centers, further aiding in weight management. For example, semaglutide is highly effective in reducing HbA1c levels and supporting weight loss in patients with type 2 diabetes. NiHowdy ensures patients can access these life-changing therapies affordably and conveniently.

What are GLP-1 Receptor Agonists used to treat?

Type 2 Diabetes

GLP-1 receptor agonists are primarily used to manage type 2 diabetes by improving glycemic control. These medications stimulate insulin release and reduce glucagon secretion in a glucose-dependent manner, lowering blood sugar levels without causing hypoglycemia. Additionally, their weight loss benefits make them particularly useful for overweight or obese patients with type 2 diabetes.

Weight Management

In patients with obesity, GLP-1 receptor agonists such as semaglutide are approved for weight management. By slowing gastric emptying and influencing appetite regulation centers in the brain, these medications reduce caloric intake and promote sustained weight loss, improving overall metabolic health.

Prediabetes

In individuals with prediabetes, GLP-1 receptor agonists help improve glucose tolerance and prevent the progression to type 2 diabetes. Their weight loss effects further enhance insulin sensitivity and support metabolic health.

Cardiovascular Risk Reduction

For patients with type 2 diabetes and cardiovascular disease, GLP-1 receptor agonists like liraglutide and semaglutide have demonstrated cardiovascular benefits, including reduced risk of major adverse cardiovascular events. This dual action of glycemic control and heart protection makes them a valuable choice for high-risk patients.

Who should consider GLP-1 Receptor Agonists medications?

Adults

Adults with type 2 diabetes or obesity are the primary candidates for GLP-1 receptor agonists. These medications improve glycemic control, support weight loss, and reduce cardiovascular risk. Healthcare providers tailor therapy based on individual needs and health goals, ensuring effective treatment outcomes.

Children

GLP-1 receptor agonists may be used in pediatric populations for type 2 diabetes management when lifestyle interventions and other medications are insufficient. Doses are carefully adjusted to the child's weight and age, with close monitoring to ensure safety and efficacy.

Seniors

Seniors with type 2 diabetes or obesity benefit significantly from GLP-1 receptor agonists due to their favorable safety profile and additional cardiovascular benefits. Age-related changes in kidney function and other comorbidities require careful monitoring and dose adjustments to optimize therapy.

Are GLP-1 Receptor Agonists safe?

GLP-1 receptor agonists are generally safe when used as prescribed. Common side effects include nausea, vomiting, diarrhea, and mild gastrointestinal discomfort, which often improve over time. Rare but serious risks include pancreatitis and gallbladder-related issues, such as cholelithiasis. Regular follow-ups with a healthcare provider ensure that side effects are managed and the therapy remains effective and safe.

Can I take GLP-1 Receptor Agonists during pregnancy?

GLP-1 receptor agonists are generally avoided during pregnancy due to limited safety data. Patients with diabetes or obesity who are pregnant or planning pregnancy should consult their healthcare provider for alternative treatment options.

Are GLP-1 Receptor Agonists safe to take while lactating?

The safety of GLP-1 receptor agonists during lactation is not well established. These medications may pass into breast milk, and alternative therapies are often recommended for breastfeeding individuals. Patients should discuss risks and benefits with their healthcare provider.

Are GLP-1 Receptor Agonists controlled substances?

GLP-1 receptor agonists are not classified as controlled substances. However, they require a prescription and medical supervision to ensure appropriate use, particularly for managing chronic conditions like diabetes and obesity.

Side effects of GLP-1 Receptor Agonists?

GLP-1 receptor agonists are generally well-tolerated, but they can cause side effects. Common side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, or constipation, which are more pronounced at the beginning of therapy and typically subside over time. Less common side effects include fatigue, dizziness, and injection site reactions for those using injectable formulations. Rare but serious risks include pancreatitis, which presents with severe abdominal pain and requires immediate medical attention, and gallbladder-related complications like gallstones. Patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid GLP-1 receptor agonists due to potential risks of thyroid-related side effects. Regular monitoring and open communication with healthcare providers help manage side effects effectively, ensuring the safe and successful use of these medications.

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Cost considerations and insurance coverage for GLP-1 Receptor Agonists

The cost of GLP-1 receptor agonists varies based on the specific medication and formulation. These medications, particularly newer agents like semaglutide, can be expensive. However, many insurance plans cover them for approved indications such as type 2 diabetes and obesity. NiHowdy offers discounts, rebates, and Bitcoin rewards to ensure these life-changing treatments remain accessible and cost-effective.

How do I get rebates on GLP-1 Receptor Agonists?

NiHowdy's Bitcoin rebate program for GLP-1 receptor agonist prescriptions provides patients with a unique opportunity to save on healthcare costs while earning potential financial growth. This innovative approach makes managing conditions like type 2 diabetes and obesity both affordable and rewarding, improving access to transformative treatments while building long-term value.

Therapeutic Classes linked to GLP-1 Receptor Agonists

Antidiabetics (Diabetes Management)

Medical Conditions treated by GLP-1 Receptor Agonists

Obesity

Everyday Health Concerns related to GLP-1 Receptor Agonists

Endocrine

Enlarged thyroid gland

Hot flashes

Unexplained weight gain