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Wegovy
Wegovy (generic name: semaglutide) is a once-weekly injectable medication used for chronic weight management in adults with obesity or those who are overweight with weight-related medical problems. It belongs to a class of medications called GLP-1 receptor agonists, which help regulate appetite and reduce food intake by mimicking a hormone that targets areas of the brain responsible for appetite control. Wegovy is designed to be used alongside a reduced-calorie diet and increased physical activity.
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Frequently Asked Questions
How long does it take for Wegovy to work?
Weight loss with Wegovy typically begins within 4 to 8 weeks, but more significant weight loss is usually seen after several months of treatment, especially when combined with diet and exercise.
Can I take Wegovy if I don’t have diabetes?
Yes, Wegovy is approved for weight management in individuals with obesity or overweight, regardless of whether they have diabetes. However, it also helps regulate blood sugar levels, which may be beneficial for those with type 2 diabetes.
What should I do if I miss a dose of Wegovy?
If you miss a dose of Wegovy, take it as soon as you remember, as long as it’s within 5 days of the missed dose. If it’s been more than 5 days, skip the dose and continue with your regular schedule.
Does Wegovy cause nausea?
Yes, nausea is a common side effect, especially during the first few weeks of treatment as your body adjusts to the medication. This typically subsides over time as your dose is increased.
Is Wegovy safe for long-term use?
Wegovy is intended for long-term use in managing chronic weight conditions, but regular monitoring by a healthcare provider is recommended to ensure it remains effective and safe for you.
Comprehensive Drug Guide
How Does Wegovy Work?
Wegovy works by activating GLP-1 receptors, which help regulate appetite and calorie intake. By mimicking the naturally occurring hormone GLP-1, it slows gastric emptying, reduces hunger, and increases feelings of fullness. This leads to reduced caloric intake and weight loss. Wegovy also helps regulate blood sugar levels, making it beneficial for individuals with obesity-related conditions such as type 2 diabetes.
Common Dosages
- 0.25 mg once weekly for 4 weeks, increasing to
- 0.5 mg once weekly for 4 weeks, then to
- 1 mg, 1.7 mg, and eventually 2.4 mg once weekly as the maintenance dose.
Typical Dosing
- Start with 0.25 mg once weekly for the first 4 weeks, followed by gradual dose increases every 4 weeks until reaching the maintenance dose of 2.4 mg once weekly. Wegovy should be injected subcutaneously in the abdomen, thigh, or upper arm.
Typical Dosing
FDA Approved Indications
- Chronic weight management in adults with a BMI ≥30 kg/m² (obesity)
- Weight management in adults with a BMI ≥27 kg/m² (overweight) and at least one weight-related condition (e.g., hypertension, type 2 diabetes, dyslipidemia)
Who Shouldn't Take Wegovy?
- A personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)
- A known hypersensitivity to semaglutide or any components of the formulation
- Pregnancy, as weight loss is not recommended during pregnancy
Advice From The Pharmacist
- Administer Wegovy once weekly, on the same day each week, with or without food. If you miss a dose and it’s been less than 5 days, administer the missed dose as soon as possible. If more than 5 days have passed, skip the missed dose and resume your regular schedule.
- Store Wegovy pens in the refrigerator, but they can be kept at room temperature for up to 28 days if necessary.
- Ensure proper injection technique by rotating injection sites to avoid irritation. Never inject into areas of bruised, tender, or scarred skin.
- Follow a reduced-calorie diet and increase physical activity to maximize the effectiveness of Wegovy.
Side Effects of Wegovy
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
Uncommon/Severe Side Effects
- Gallbladder disease (gallstones or inflammation)
- Thyroid tumors, including thyroid cancer
Risks and Warnings of Wegovy
- Thyroid Tumor Risk: Wegovy carries a potential risk of thyroid tumors, including medullary thyroid carcinoma (MTC). Report any symptoms such as a lump in the neck, hoarseness, or difficulty swallowing to your healthcare provider.
- Pancreatitis: Wegovy can increase the risk of pancreatitis. If you experience severe abdominal pain, nausea, or vomiting, discontinue use and seek medical attention immediately.
- Hypoglycemia: Wegovy may increase the risk of hypoglycemia, especially in patients taking insulin or other medications that lower blood sugar.
Interactions with Wegovy
Common Drug Interactions
- Insulin or other diabetes medications: Wegovy may increase the risk of hypoglycemia when used in combination with insulin or sulfonylureas.
- Oral medications: Wegovy slows gastric emptying, which may affect the absorption of some oral medications. Consult your healthcare provider about potential interactions.
Alternatives to Wegovy
- Saxenda (liraglutide): Another GLP-1 receptor agonist used for weight management.
- Contrave (naltrexone/bupropion): A combination medication used for chronic weight management.
- Qsymia (phentermine/topiramate): A weight loss medication that combines an appetite suppressant with an anticonvulsant.
- Orlistat: A lipase inhibitor that prevents the absorption of fats from the diet.
