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TriaDime-80
TriaDime-80 is a combination antibiotic containing trimethoprim and sulfamethoxazole, used to treat various bacterial infections. This medication is commonly prescribed for infections such as urinary tract infections (UTIs), bronchitis, pneumonia, and ear infections. The combination of these two antibiotics works synergistically to block the production of folic acid in bacteria, which is essential for their growth and survival.
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Frequently Asked Questions
How long does it take for TriaDime-80 to work?
You may start to feel better within a few days of starting TriaDime-80, but it is important to continue taking it for the full prescribed duration to ensure the infection is fully treated.
Can I drink alcohol while taking TriaDime-80?
It is best to avoid alcohol while taking this medication, as it may increase the risk of side effects like nausea, vomiting, and stomach upset.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Can TriaDime-80 be used to treat a cold or flu?
No, TriaDime-80 is an antibiotic and is not effective against viral infections like the common cold or flu.
Is TriaDime-80 safe for children?
Yes, but the dosage must be adjusted based on the child’s weight and the type of infection being treated. Always follow your doctor’s instructions for pediatric use.
Comprehensive Drug Guide
How Does TriaDime-80 Work?
TriaDime-80 works by inhibiting the production of folic acid in bacteria, which is necessary for DNA synthesis and cellular reproduction. Sulfamethoxazole inhibits the first step of folic acid synthesis, while trimethoprim blocks the next step, making the combination more effective than either drug alone. This dual mechanism helps to prevent bacterial growth and reproduction, allowing the body’s immune system to eliminate the infection.
Common Dosages
- Trimethoprim 80 mg / Sulfamethoxazole 400 mg (standard dose)
Typical Dosing
- For most infections, the typical adult dose is one tablet every 12 hours (twice daily) for 10 to 14 days, depending on the type and severity of the infection.
- For Pneumocystis jirovecii pneumonia (PJP), higher doses may be required, and the dosing frequency will depend on your doctor’s instructions.
Typical Dosing
FDA Approved Indications
- Urinary tract infections (UTIs)
- Bronchitis
- Traveler’s diarrhea
- Pneumocystis jirovecii pneumonia (PJP)
- Ear infections (otitis media)
- Shigellosis
Who Shouldn't Take TriaDime-80?
- Known hypersensitivity to sulfonamides, trimethoprim, or any of the components of the medication.
- Severe liver disease or kidney disease unless closely monitored.
- Megaloblastic anemia due to folate deficiency.
- Pregnant women near term or nursing mothers.
Advice From The Pharmacist
- Take TriaDime-80 with a full glass of water and drink plenty of fluids while on this medication to help prevent kidney stones.
- Complete the full course of antibiotics as prescribed, even if symptoms improve before finishing the medication.
- If you experience any signs of allergic reactions, such as rash or difficulty breathing, stop taking the medication and contact your doctor immediately.
- Avoid excessive sun exposure while taking TriaDime-80, as it can increase your sensitivity to sunlight and increase the risk of sunburn.
Side Effects of TriaDime-80
Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Loss of appetite
- Skin rash
- Headache
Uncommon/Severe Side Effects
- Severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis
- Liver or kidney problems (yellowing of the skin or eyes, dark urine, difficulty urinating)
- Blood disorders, such as low white blood cell count or anemia
Risks and Warnings of TriaDime-80
- Severe Allergic Reactions: Sulfonamide antibiotics can cause serious skin reactions and other hypersensitivity reactions. Stop using the medication and seek medical help if you notice a rash, blistering, or swelling.
- Kidney and Liver Issues: TriaDime-80 can affect kidney and liver function, especially in patients with pre-existing conditions. Blood tests may be required to monitor organ function during treatment.
- Blood Disorders: This medication may cause blood cell abnormalities, especially in people with a folate deficiency. Symptoms include fatigue, easy bruising, or pale skin.
Interactions with TriaDime-80
Common Drug Interactions
- Blood thinners: Taking TriaDime-80 with blood-thinning medications like warfarin may increase the risk of bleeding.
- Diuretics (water pills): Using this medication with diuretics can increase the risk of low blood sodium levels (hyponatremia).
- Methotrexate: Combining TriaDime-80 with methotrexate (a chemotherapy drug) may increase the risk of side effects such as bone marrow suppression.
Alternatives to TriaDime-80
- Amoxicillin-clavulanate (Augmentin): An alternative antibiotic for treating bacterial infections, including UTIs and respiratory infections.
- Nitrofurantoin (Macrobid): Often used to treat urinary tract infections.
- Ciprofloxacin (Cipro): Another broad-spectrum antibiotic used for bacterial infections, particularly for those resistant to trimethoprim-sulfamethoxazole.
