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Toviaz
Toviaz (generic name: fesoterodine fumarate) is a prescription medication used to treat symptoms of overactive bladder (OAB), such as frequent urination, urge incontinence, and urgency. It belongs to the class of drugs known as antimuscarinics or anticholinergics, which help relax the bladder muscles to prevent involuntary contractions. By reducing bladder activity, Toviaz helps individuals manage urinary frequency, leakage, and the sudden urge to urinate.
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Frequently Asked Questions
How long does it take for Toviaz to start working?
Most patients begin to see improvement in their overactive bladder symptoms within 1 to 2 weeks of starting Toviaz, but it may take up to 8 weeks to experience the full benefits.
Can I stop taking Toviaz once my symptoms improve?
You should not stop taking Toviaz without consulting your doctor. Overactive bladder symptoms may return once the medication is discontinued, and your healthcare provider can help adjust your treatment plan.
Is Toviaz safe for long-term use?
Yes, Toviaz is generally considered safe for long-term use, but your doctor will monitor for any side effects or complications, such as urinary retention or constipation, during ongoing treatment.
Can I take Toviaz with other overactive bladder medications?
Toviaz should not be combined with other anticholinergic medications due to the increased risk of side effects. Your healthcare provider may recommend other options, such as a beta-3 agonist like Myrbetriq, if additional treatment is needed.
Can Toviaz cause weight gain?
Weight gain is not a common side effect of Toviaz, but if you notice unusual weight changes, especially with fluid retention, you should inform your doctor.
Comprehensive Drug Guide
How Does Toviaz Work?
Toviaz works by blocking muscarinic receptors in the bladder. These receptors control bladder contractions, and by inhibiting them, fesoterodine reduces the frequency and intensity of involuntary bladder muscle contractions. This allows the bladder to hold more urine and decreases the urgency and frequency of urination, as well as reducing episodes of incontinence.
Common Dosages
- 4 mg extended-release tablet
- 8 mg extended-release tablet
Typical Dosing
- The usual starting dose of Toviaz is 4 mg once daily, which may be increased to 8 mg once daily based on individual response and tolerance.
- Toviaz should be taken with water and swallowed whole. It can be taken with or without food.
Typical Dosing
FDA Approved Indications
- Overactive bladder (OAB) with symptoms such as urinary frequency, urgency, and urge incontinence
Who Shouldn't Take Toviaz?
- Urinary retention (inability to empty the bladder)
- Gastric retention (severe delayed stomach emptying)
- Uncontrolled narrow-angle glaucoma
- Known hypersensitivity to fesoterodine or any other anticholinergics
- Severe liver or kidney impairment without dosage adjustment
Advice From The Pharmacist
- Toviaz should be taken once daily, preferably at the same time each day, to help manage symptoms consistently.
- Avoid crushing, chewing, or breaking the extended-release tablet, as this can interfere with the extended-release mechanism.
- Toviaz can cause dry mouth and constipation; staying hydrated and eating a fiber-rich diet may help alleviate these symptoms.
- If you experience any difficulty urinating, contact your healthcare provider immediately, as Toviaz can cause urinary retention in some individuals.
- Store Toviaz at room temperature and protect it from moisture.
Side Effects of Toviaz
Common Side Effects
- Dry mouth
- Constipation
- Drowsiness or dizziness
- Blurred vision
- Dry eyes
Uncommon/Severe Side Effects
- Severe difficulty urinating or urinary retention
- Severe abdominal pain or constipation
- Allergic reactions (e.g., rash, swelling, difficulty breathing)
- Irregular heartbeat or palpitations
Risks and Warnings of Toviaz
- Urinary Retention: Toviaz may cause or worsen urinary retention in some patients, especially those with pre-existing bladder outflow obstructions.
- Cognitive Impairment: As an anticholinergic, Toviaz can cause drowsiness, confusion, or memory problems, particularly in elderly patients.
- Gastrointestinal Issues: Toviaz may worsen gastrointestinal motility issues, such as severe constipation or gastric retention.
- Glaucoma: Toviaz should not be used in patients with uncontrolled narrow-angle glaucoma, as it can worsen intraocular pressure.
Interactions with Toviaz
Common Drug Interactions
- Anticholinergic medications: Combining Toviaz with other anticholinergic drugs (e.g., oxybutynin, solifenacin) can increase the risk of side effects like dry mouth, constipation, and blurred vision.
- CYP3A4 inhibitors: Medications like ketoconazole or clarithromycin can increase the levels of Toviaz in the blood, potentially leading to more pronounced side effects.
- Alcohol: Alcohol may increase the sedative effects of Toviaz, leading to increased drowsiness or dizziness.
Alternatives to Toviaz
- Detrol LA (tolterodine): Another antimuscarinic medication used to treat overactive bladder symptoms.
- Vesicare (solifenacin): A similar drug that works by relaxing the bladder muscles to reduce urgency and frequency.
- Myrbetriq (mirabegron): A beta-3 adrenergic agonist that treats OAB by relaxing bladder muscles without the anticholinergic side effects.
- Oxybutynin: An older anticholinergic medication available in various forms (oral, patch, gel) for the treatment of OAB.
