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Timoptic-XE
Timoptic-XE (generic name: timolol maleate) is an ophthalmic gel-forming solution used to treat elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. Timoptic-XE is a beta-blocker that helps reduce intraocular pressure by decreasing fluid production in the eye. The gel-forming solution allows for once-daily dosing, making it convenient for patients who need to control their eye pressure consistently.
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Frequently Asked Questions
How long does it take for Timoptic-XE to lower eye pressure?
Timoptic-XE typically starts lowering intraocular pressure within 1 to 2 hours after application, with maximum effects seen in about 12 hours.
Can I use Timoptic-XE with contact lenses?
No, Timoptic-XE contains preservatives that can be absorbed by soft contact lenses. You should remove your contact lenses before applying the gel and wait at least 15 minutes before reinserting them.
What should I do if I miss a dose of Timoptic-XE?
If you miss a dose, apply it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Can Timoptic-XE cause low blood pressure?
Yes, Timoptic-XE can cause systemic effects like low blood pressure, especially if absorbed into the bloodstream. Pressing on the inner corner of the eye after administration can help reduce systemic absorption.
How is Timoptic-XE different from regular Timoptic?
Timoptic-XE is a gel-forming solution that allows for once-daily dosing, whereas regular Timoptic is a traditional solution that may require twice-daily dosing.
Comprehensive Drug Guide
How Does Timoptic-XE Work?
Timoptic-XE reduces intraocular pressure by inhibiting the production of aqueous humor, the fluid inside the eye. By reducing this fluid, Timoptic-XE helps to lower the pressure inside the eye, decreasing the risk of damage to the optic nerve and preventing vision loss from glaucoma or ocular hypertension.
Common Dosages
- 0.25% ophthalmic gel-forming solution
- 0.5% ophthalmic gel-forming solution
Typical Dosing
- For glaucoma and ocular hypertension: The recommended dose is one drop of 0.25% or 0.5% in the affected eye(s) once daily, usually in the morning. The dosage may be adjusted based on the patient's response to the treatment.
Typical Dosing
FDA Approved Indications
- Open-angle glaucoma
- Ocular hypertension
Who Shouldn't Take Timoptic-XE?
- Bronchial asthma or a history of asthma
- Severe chronic obstructive pulmonary disease (COPD)
- Bradycardia, heart block, or heart failure
- Known hypersensitivity to timolol or any components of the solution
Advice From The Pharmacist
- Administer Timoptic-XE once daily, preferably in the morning. Avoid touching the tip of the bottle to your eye or any surface to prevent contamination.
- After applying the drops, keep your eyes closed and apply gentle pressure to the corner of the eye (near the nose) for 1 to 2 minutes to prevent systemic absorption.
- Do not stop using Timoptic-XE suddenly without consulting your doctor, as this can lead to a sudden increase in intraocular pressure.
- Store Timoptic-XE upright to ensure proper gel formation when applied.
Side Effects of Timoptic-XE
Common Side Effects
- Temporary blurred vision after applying the gel
- Mild burning or stinging
- Dry eyes or watery eyes
- Headache
Uncommon/Severe Side Effects
- Shortness of breath or wheezing
- Bradycardia (slow heart rate)
- Dizziness or fainting
- Severe allergic reactions (rash, swelling, difficulty breathing)
Risks and Warnings of Timoptic-XE
- Respiratory Effects: Timoptic-XE may cause breathing difficulties in patients with asthma or COPD. Avoid use in these patients unless absolutely necessary.
- Cardiovascular Effects: Timoptic-XE may reduce heart rate and blood pressure, particularly in patients with pre-existing heart conditions. Monitor for bradycardia and hypotension.
- Systemic Absorption: Pressing on the inner corner of the eye after applying the drops can reduce systemic absorption and the risk of side effects like low blood pressure and slow heart rate.
Interactions with Timoptic-XE
Common Drug Interactions
- Beta-blockers: Using Timoptic-XE with systemic beta-blockers (e.g., atenolol, metoprolol) may increase the risk of low blood pressure or slow heart rate.
- Calcium channel blockers: Combining Timoptic-XE with drugs like verapamil or diltiazem can increase the risk of cardiovascular effects such as bradycardia and hypotension.
- Digoxin: Timoptic-XE may enhance the effects of digoxin, increasing the risk of bradycardia.
Alternatives to Timoptic-XE
- Latanoprost (Xalatan): A prostaglandin analog used to lower intraocular pressure in glaucoma patients.
- Brimonidine (Alphagan): An alpha agonist used to reduce eye pressure.
- Dorzolamide (Trusopt): A carbonic anhydrase inhibitor used to lower intraocular pressure.
- Travoprost (Travatan Z): Another prostaglandin analog used for glaucoma and ocular hypertension.
