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Tiadylt ER
Tiadylt ER (generic name: diltiazem hydrochloride) is a calcium channel blocker used to treat high blood pressure (hypertension) and chronic stable angina (chest pain). It works by relaxing blood vessels and reducing the workload on the heart, making it easier for blood to flow and lowering the heart's oxygen demand. Tiadylt ER helps reduce the risk of heart attacks and strokes by controlling blood pressure and reducing the frequency of angina episodes.
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Frequently Asked Questions
How long does it take for Tiadylt ER to start working?
Tiadylt ER may start lowering blood pressure within a few hours, but it can take 1 to 2 weeks to see the full effect.
Can I drink alcohol while taking Tiadylt ER?
You should limit or avoid alcohol, as it can enhance the blood pressure-lowering effects of Tiadylt ER and increase the risk of side effects such as dizziness.
What should I do if I miss a dose of Tiadylt ER?
If you miss a dose, take it as soon as you remember. If it’s close to your next scheduled dose, skip the missed dose and continue as normal. Do not double the dose.
Can Tiadylt ER be used for arrhythmias?
Yes, Tiadylt ER is sometimes used off-label to treat certain types of arrhythmias, such as atrial fibrillation. Always follow your doctor’s recommendations.
Can Tiadylt ER cause weight gain?
Tiadylt ER can cause swelling (edema) in the legs or feet, which may lead to temporary weight gain. If you experience significant swelling, consult your healthcare provider.
Comprehensive Drug Guide
How Does Tiadylt ER Work?
Tiadylt ER works by blocking calcium ions from entering the smooth muscle cells of the heart and blood vessels. This action leads to relaxation of blood vessels, reduced heart rate, and decreased blood pressure, making it easier for the heart to pump blood and reducing the oxygen demand of the heart muscles.
Common Dosages
- 120 mg
- 180 mg
- 240 mg
- 300 mg
- 360 mg
- 420 mg
Typical Dosing
- For hypertension: The usual starting dose is 180 mg to 240 mg once daily, with adjustments made based on response. The maximum recommended dose is 420 mg per day.
- For angina: The typical dose ranges from 120 mg to 360 mg daily, depending on the severity of symptoms.
Typical Dosing
FDA Approved Indications
- Hypertension (high blood pressure)
- Chronic stable angina (chest pain)
- Atrial fibrillation and atrial flutter (off-label use)
Who Shouldn't Take Tiadylt ER?
- Severe hypotension (low blood pressure)
- Advanced heart block (without a pacemaker)
- Severe heart failure
- Known hypersensitivity to diltiazem or any of its components
Advice From The Pharmacist
- Take Tiadylt ER once daily, preferably at the same time each day. It can be taken with or without food, but consistency is important.
- Do not crush or chew the extended-release capsules, as this may interfere with the controlled-release mechanism.
- Regularly monitor your blood pressure to ensure the medication is effectively managing your condition.
- Avoid grapefruit or grapefruit juice while taking Tiadylt ER, as it can increase the risk of side effects.
Side Effects of Tiadylt ER
Common Side Effects
- Dizziness or lightheadedness
- Headache
- Fatigue
- Swelling in the legs, ankles, or feet (edema)
- Slow heart rate (bradycardia)
Uncommon/Severe Side Effects
- Severe low blood pressure (hypotension)
- Heart failure
- Severe allergic reactions (swelling, rash, difficulty breathing)
- Liver dysfunction
Risks and Warnings of Tiadylt ER
- Heart Failure Risk: Tiadylt ER can worsen symptoms in patients with heart failure. Close monitoring is recommended for patients with a history of heart conditions.
- Hypotension: The medication can cause dangerously low blood pressure, especially in combination with other blood pressure-lowering medications. Dizziness or fainting may occur.
- Bradycardia and Heart Block: Tiadylt ER can slow the heart rate and cause heart block in some individuals. Regular ECG monitoring may be necessary in patients with pre-existing heart conditions.
Interactions with Tiadylt ER
Common Drug Interactions
- Beta-blockers: Combining Tiadylt ER with beta-blockers (e.g., metoprolol) may increase the risk of bradycardia and heart block.
- Digoxin: Tiadylt ER may increase blood levels of digoxin, leading to potential toxicity. Monitoring is recommended.
- CYP3A4 inhibitors: Medications like ketoconazole or ritonavir can increase the levels of Tiadylt ER, raising the risk of side effects.
Alternatives to Tiadylt ER
- Amlodipine (Norvasc): Another calcium channel blocker used for hypertension and angina.
- Verapamil: A similar calcium channel blocker used for high blood pressure and heart rate control.
- Lisinopril (Zestril): An ACE inhibitor used to treat high blood pressure and heart failure.
- Atenolol (Tenormin): A beta-blocker used to treat hypertension and angina.
