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Super Quad-Mix
Super Quad-Mix is an injectable compounded medication used to treat erectile dysfunction (ED). It contains four active ingredients: papaverine, phentolamine, alprostadil, and atropine. This combination enhances blood flow to the penis, helping men achieve and maintain an erection. Super Quad-Mix is typically prescribed when other treatments, such as oral PDE5 inhibitors (e.g., sildenafil), are ineffective or not suitable. It is a stronger formulation compared to Tri-Mix, often recommended for men with more severe ED.
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Frequently Asked Questions
How long does it take for Super Quad-Mix to work?
Super Quad-Mix usually works within 5 to 15 minutes of injection, with effects lasting for up to an hour.
Can I adjust the dose of Super Quad-Mix on my own?
No, you should never adjust your dose without consulting your healthcare provider. Your doctor will determine the appropriate dose based on your response to the medication.
What should I do if I experience an erection lasting more than 4 hours?
This is a medical emergency known as priapism. You should seek immediate medical attention to prevent long-term damage.
How often can I use Super Quad-Mix?
Super Quad-Mix should not be used more than once in a 24-hour period and no more than 3 times per week. Overuse can increase the risk of side effects.
Can I store Super Quad-Mix at room temperature?
No, Super Quad-Mix should be stored in the refrigerator to maintain its effectiveness. Allow the medication to warm to room temperature before injecting, but do not freeze it.
Comprehensive Drug Guide
How Does Super Quad-Mix Work?
- Papaverine acts as a vasodilator, relaxing the blood vessels to increase blood flow.
- Phentolamine blocks alpha-adrenergic receptors, further preventing constriction of blood vessels.
- Alprostadil is a prostaglandin that stimulates blood flow by dilating blood vessels.
- Atropine helps to enhance the effects of the other agents by reducing vascular resistance and improving blood flow.
Common Dosages
- Papaverine: 30 mg/ml to 150 mg/ml
- Phentolamine: 0.5 mg/ml to 5 mg/ml
- Alprostadil: 10 mcg/ml to 20 mcg/ml
- Atropine: 0.05 mg/ml to 0.5 mg/ml
Typical Dosing
- Self-injection: The dose is typically administered as an injection into the base or side of the penis 5 to 15 minutes before sexual activity.
- The initial dose is determined by a healthcare provider and adjusted based on effectiveness and side effects.
Typical Dosing
FDA Approved Indications
- Erectile dysfunction (ED) in adult men, particularly those who do not respond well to oral medications or require a stronger formulation than Tri-Mix or other ED treatments.
Who Shouldn't Take Super Quad-Mix?
- Hypersensitivity to any of the ingredients
- Conditions that predispose to priapism (e.g., sickle cell anemia or leukemia)
- Penile anatomical abnormalities like Peyronie’s disease
- Active penile infection or inflammation
Advice From The Pharmacist
- Be sure to receive proper instruction on the injection technique before using Super Quad-Mix at home.
- Rotate injection sites with each use to avoid scar tissue formation.
- If an erection lasts longer than 4 hours, seek immediate medical help to avoid permanent damage.
- Store Super Quad-Mix in the refrigerator, and allow it to reach room temperature before administering.
- Discard used syringes and needles safely and never reuse them.
Side Effects of Super Quad-Mix
Common Side Effects
- Mild pain or bruising at the injection site
- Temporary swelling or redness at the injection site
- Prolonged erection (priapism)
- Dizziness or low blood pressure
Uncommon/Severe Side Effects
- Priapism (erections lasting longer than 4 hours)
- Penile fibrosis (scar tissue formation)
- Infection at the injection site
Risks and Warnings of Super Quad-Mix
- Risk of Priapism: Super Quad-Mix can cause erections that last too long, which may result in permanent tissue damage. Seek medical attention if an erection lasts more than 4 hours.
- Injection Site Issues: Regularly rotating injection sites is important to prevent scar tissue formation and fibrosis.
- Cardiovascular Risks: Patients with heart conditions should use Super Quad-Mix cautiously, as it may lower blood pressure.
Interactions with Super Quad-Mix
Common Drug Interactions
- Blood pressure medications: Super Quad-Mix can interact with medications that lower blood pressure, increasing the risk of dizziness or fainting.
- Anticoagulants: Increased risk of bleeding or bruising at the injection site when used with blood thinners.
- Other ED medications: Super Quad-Mix should not be combined with other ED treatments unless directed by your healthcare provider.
Alternatives to Super Quad-Mix
- Caverject (alprostadil): A single-agent injectable treatment for erectile dysfunction.
- Edex (alprostadil): Another injectable ED treatment containing only alprostadil.
- Tri-Mix: A similar compounded formulation with three active ingredients (without atropine).
- Oral PDE5 inhibitors: Such as sildenafil (Viagra) or tadalafil (Cialis), which may be considered if suitable.
