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Sulfacetamide-prednisoLONE
Sulfacetamide-Prednisolone is a combination ophthalmic (eye) solution used to treat inflammatory conditions of the eye that are also associated with bacterial infections. The solution contains two medications:
- Sulfacetamide sodium, a sulfonamide antibiotic that inhibits bacterial growth.
- Prednisolone, a corticosteroid that reduces inflammation, redness, and swelling.
This combination is often prescribed for conditions such as conjunctivitis, blepharitis, and corneal injuries where inflammation is accompanied by a bacterial infection.
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Frequently Asked Questions
How long does it take for Sulfacetamide-Prednisolone to work?
You may start to see improvement in symptoms within 1-2 days of starting treatment, but it's essential to complete the full course as prescribed to prevent recurrence of the infection.
Can I use Sulfacetamide-Prednisolone if I wear contact lenses?
No, it is recommended to remove contact lenses before using Sulfacetamide-Prednisolone, and wait at least 15 minutes after applying the drops before reinserting your lenses.
What should I do if I miss a dose?
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Can I use other eye drops while using Sulfacetamide-Prednisolone?
Yes, but it's important to wait at least 5 to 10 minutes between different eye medications to allow proper absorption. Always consult your doctor before using multiple eye treatments.
How long can I use Sulfacetamide-Prednisolone?
Your doctor will prescribe the duration of use, which may vary depending on the condition being treated. Prolonged use of corticosteroids like prednisolone can lead to serious side effects, so regular monitoring is essential.
Comprehensive Drug Guide
How Does Sulfacetamide-prednisoLONE Work?
- Sulfacetamide sodium works by interfering with the ability of bacteria to synthesize folic acid, which is necessary for bacterial growth and multiplication. This helps to control the bacterial infection.
- Prednisolone acts by suppressing the immune response that causes inflammation. It reduces swelling, redness, and irritation in the eye by inhibiting the release of inflammatory mediators.
Common Dosages
- Sulfacetamide 10% with Prednisolone 0.2% The typical dosing schedule involves applying the solution to the affected eye(s) multiple times per day, usually:
- 1-2 drops every 4 to 6 hours or as directed by a healthcare provider.
Typical Dosing
- For mild infections or inflammation: 1-2 drops in the affected eye(s) every 4-6 hours.
- For more severe infections or inflammation: The frequency of administration may be increased to every 2 hours, followed by a gradual reduction as symptoms improve.
Typical Dosing
FDA Approved Indications
- Bacterial conjunctivitis (pink eye)
- Blepharitis (inflammation of the eyelids)
- Keratitis (corneal inflammation)
- Corneal ulcers (open sores on the cornea)
- Post-surgical inflammation of the eye
Who Shouldn't Take Sulfacetamide-prednisoLONE?
- Viral or fungal eye infections (e.g., herpes simplex keratitis or fungal keratitis).
- Known hypersensitivity to sulfacetamide, prednisolone, or other sulfonamides or corticosteroids.
- Untreated purulent (pus-filled) bacterial infections.
- Tuberculosis of the eye.
Advice From The Pharmacist
- Shake well before use: If the ophthalmic solution contains a suspension (prednisolone acetate), shake the bottle well before applying the drops.
- Avoid contact lenses: Do not wear contact lenses while using Sulfacetamide-Prednisolone, as the medication may adhere to the lenses and cause irritation. Wait at least 15 minutes after applying the drops before putting in contact lenses.
- Complete the full course: Even if symptoms improve, continue using the drops for the full prescribed duration to ensure that the infection is completely cleared.
- Proper administration: Wash your hands before applying the drops. Tilt your head back, pull down the lower eyelid, and place the drops into the pocket formed. Avoid touching the dropper to your eye or any surface to prevent contamination.
Side Effects of Sulfacetamide-prednisoLONE
Common Side Effects
- Mild eye burning or stinging upon application
- Blurred vision for a few minutes after administration
- Increased sensitivity to light
- Dryness or redness of the eyes
Uncommon/Severe Side Effects
- Increased intraocular pressure: Prolonged use of corticosteroids like prednisolone can lead to an increase in eye pressure, potentially leading to glaucoma.
- Cataract formation: Long-term use of corticosteroids may increase the risk of developing cataracts.
- Allergic reactions: Rash, itching, or swelling (especially of the face, tongue, or throat) may indicate an allergic reaction and require immediate medical attention.
- Worsening of infections: In some cases, prolonged use may suppress the immune response, allowing infections (such as fungal or viral) to worsen.
Risks and Warnings of Sulfacetamide-prednisoLONE
- Prolonged use: Extended use of corticosteroids in the eye can lead to serious side effects, including glaucoma, cataracts, and secondary infections. Regular follow-up visits with an ophthalmologist are essential for monitoring.
- Do not use in viral or fungal infections: Sulfacetamide-Prednisolone is not effective against viral or fungal eye infections and may worsen these conditions.
- Risk of antibiotic resistance: Overuse or inappropriate use of sulfacetamide may contribute to the development of antibiotic resistance.
Interactions with Sulfacetamide-prednisoLONE
Common Drug Interactions
- Topical NSAIDs: Using nonsteroidal anti-inflammatory drugs (NSAIDs), such as ketorolac, concurrently with corticosteroids may delay healing or mask the symptoms of an infection.
- Systemic corticosteroids: Patients using other corticosteroids (oral or inhaled) may experience additive effects, such as increased intraocular pressure or weakened immune response.
Alternatives to Sulfacetamide-prednisoLONE
- Tobradex (Tobramycin and Dexamethasone): Another combination antibiotic-steroid eye drop used to treat bacterial eye infections with inflammation.
- Maxitrol (Neomycin, Polymyxin B, and Dexamethasone): An alternative combination for bacterial infections with inflammation of the eye.
- Lotemax (Loteprednol): A steroid ophthalmic solution with fewer side effects related to intraocular pressure, used to treat inflammation of the eye.
- Vigamox (Moxifloxacin): A fluoroquinolone antibiotic eye drop for bacterial eye infections.