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Relafen DS
Relafen DS (nabumetone) is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to relieve pain and inflammation associated with conditions such as osteoarthritis and rheumatoid arthritis. It works by inhibiting the production of prostaglandins, which are chemicals in the body that promote inflammation, pain, and fever.
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Frequently Asked Questions
How quickly does Relafen DS start to work?
Patients may begin to feel relief from pain and inflammation within a few days of starting treatment, but optimal effects may take longer to achieve.
Can I stop taking Relafen DS suddenly?
It is generally safe to discontinue Relafen DS without tapering, but consult your healthcare provider if you have concerns about your treatment.
Are there any specific dietary restrictions while taking Relafen DS?
There are no specific dietary restrictions, but maintaining a balanced diet can support overall health.
What should I do if I miss a dose of Relafen DS?
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Is Relafen DS safe for long-term use?
Relafen DS can be used long-term under medical supervision, but regular monitoring is essential to assess effectiveness and any potential side effects, particularly concerning gastrointestinal and cardiovascular health.
Comprehensive Drug Guide
How Does Relafen DS Work?
Nabumetone, the active ingredient in Relafen DS, works by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). By blocking these enzymes, nabumetone reduces the synthesis of prostaglandins, which leads to decreased inflammation, pain, and fever.
Common Dosages
- Tablets: 500 mg and 750 mg.
Typical Dosing
- The usual starting dose for adults is 1000 mg (two 500 mg tablets) taken once daily or 500 mg twice daily. The dosage may be adjusted based on the patient's response, with a maximum daily dose not exceeding 2000 mg.
Typical Dosing
FDA Approved Indications
- Relief of signs and symptoms of osteoarthritis.
- Relief of signs and symptoms of rheumatoid arthritis.
Who Shouldn't Take Relafen DS?
- Known hypersensitivity to nabumetone or any components of the formulation.
- Active gastrointestinal bleeding or peptic ulcer disease.
- History of asthma, urticaria, or other allergic reactions after taking NSAIDs.
- Severe liver or kidney disease.
Advice From The Pharmacist
- Take Relafen DS exactly as prescribed, and do not exceed the recommended dose to minimize the risk of gastrointestinal or cardiovascular side effects.
- Monitor for any signs of gastrointestinal bleeding (such as black or bloody stools) or severe allergic reactions (such as rash, itching, or difficulty breathing).
- Regular follow-ups with your healthcare provider may be necessary to monitor kidney function and overall health during long-term use.
Side Effects of Relafen DS
Common Side Effects
- Nausea
- Diarrhea or constipation
- Abdominal pain
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulcers
- Severe allergic reactions (such as rash, itching, or difficulty breathing)
- Liver or kidney problems
Risks and Warnings of Relafen DS
- Cardiovascular Risk: NSAIDs, including nabumetone, may increase the risk of serious cardiovascular events, including heart attack and stroke, particularly with prolonged use.
- Gastrointestinal Risk: Prolonged use of NSAIDs can lead to serious gastrointestinal side effects, including bleeding, ulceration, and perforation.
- Renal Impairment: Use caution in patients with renal impairment, as NSAIDs can further decrease renal function.
Interactions with Relafen DS
Common Drug Interactions
- Other NSAIDs: Concurrent use of other NSAIDs may increase the risk of gastrointestinal side effects.
- Anticoagulants: Caution is advised when used with anticoagulants, as this may increase the risk of bleeding.
- Diuretics: NSAIDs can reduce the effectiveness of certain diuretics and may lead to renal impairment in susceptible individuals.
Alternatives to Relafen DS
- Other NSAIDs: Such as ibuprofen or naproxen, which may be considered for similar indications.
- Corticosteroids: For inflammatory conditions, corticosteroids may be used in specific cases where NSAIDs are contraindicated or insufficient.