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Relafen
Relafen, the brand name for nabumetone, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation caused by conditions such as osteoarthritis and rheumatoid arthritis. It works by reducing the production of substances in the body that cause inflammation, pain, and fever. Relafen helps relieve symptoms such as joint stiffness, swelling, and discomfort, improving daily functioning in individuals with arthritis.
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Frequently Asked Questions
How long does it take for Relafen to start working?
Relafen typically begins to relieve pain and inflammation within 1-2 hours of taking a dose. However, it may take a few days of regular use to experience the full benefits for conditions like arthritis.
Can I take Relafen long-term?
Relafen can be taken long-term for chronic conditions like osteoarthritis or rheumatoid arthritis, but regular monitoring by your healthcare provider is important to check for potential side effects such as gastrointestinal bleeding or kidney problems.
Can I take Relafen with other pain relievers?
You should avoid taking Relafen with other NSAIDs (such as ibuprofen or aspirin) to reduce the risk of gastrointestinal bleeding. However, it may be safe to take acetaminophen (Tylenol) with Relafen for additional pain relief. Always check with your healthcare provider before combining medications.
What should I do if I miss a dose of Relafen?
If you miss a dose of Relafen, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Can I drink alcohol while taking Relafen?
It is best to avoid alcohol while taking Relafen, as alcohol can increase the risk of gastrointestinal bleeding.
Comprehensive Drug Guide
How Does Relafen Work?
Relafen (nabumetone) works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins—chemicals in the body that cause inflammation, pain, and fever. By blocking COX-2 (and to some extent COX-1), nabumetone reduces inflammation and pain in the joints and tissues, helping to improve mobility and comfort in patients with arthritis.
Common Dosages
- 500 mg tablets
- 750 mg tablets
Typical Dosing
- The typical starting dose of Relafen is 1000 mg once daily, usually taken before bedtime. Depending on the patient's response, the dose may be increased to 1000-2000 mg per day, divided into one or two doses.
- The dose may be adjusted based on the severity of symptoms and patient tolerability. Taking Relafen with food can help reduce stomach upset.
Typical Dosing
FDA Approved Indications
- Relief of the signs and symptoms of osteoarthritis.
- Relief of the signs and symptoms of rheumatoid arthritis.
Who Shouldn't Take Relafen?
- Known hypersensitivity to nabumetone, aspirin, or other NSAIDs.
- Active gastrointestinal bleeding or peptic ulcers.
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs.
- Severe kidney or liver impairment.
- Coronary artery bypass graft (CABG) surgery: Relafen should not be used in the peri-operative period of CABG due to an increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Relafen with food or milk to help reduce stomach irritation and minimize the risk of gastrointestinal side effects such as nausea or stomach pain.
- Do not take more than the prescribed dose. High doses of NSAIDs can increase the risk of side effects, including gastrointestinal bleeding or ulcers.
- Avoid alcohol while taking Relafen, as it may increase the risk of stomach bleeding.
- If you are taking blood thinners (e.g., warfarin), consult your healthcare provider before using Relafen, as NSAIDs can increase the risk of bleeding.
- Monitor for signs of gastrointestinal problems such as stomach pain, black or tarry stools, or vomiting blood, and seek medical attention immediately if these occur.
Side Effects of Relafen
Common Side Effects
- Stomach pain or discomfort
- Diarrhea or constipation
- Nausea
- Heartburn
- Dizziness or headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding: Symptoms may include black or tarry stools, vomiting blood, or severe stomach pain.
- Heart attack or stroke: NSAIDs, including Relafen, may increase the risk of heart attack or stroke, particularly with long-term use or in individuals with cardiovascular risk factors.
- Kidney problems: Symptoms may include reduced urination, swelling in the legs or feet, and unusual fatigue.
Risks and Warnings of Relafen
- Gastrointestinal risks: Like other NSAIDs, Relafen increases the risk of gastrointestinal bleeding, ulcers, and perforation of the stomach or intestines. These events can occur at any time and without warning, especially in older adults.
- Cardiovascular risks: NSAIDs, including Relafen, can increase the risk of heart attack or stroke. This risk may be higher in individuals with pre-existing heart disease or risk factors such as smoking or high blood pressure.
- Kidney and liver effects: Relafen may impair kidney or liver function, especially in individuals with pre-existing kidney or liver conditions. Regular monitoring of kidney and liver function may be needed.
- Allergic reactions: Some individuals may develop severe allergic reactions, including anaphylaxis, after taking Relafen. Discontinue use and seek medical attention if symptoms such as rash, swelling, or difficulty breathing occur.
Interactions with Relafen
Common Drug Interactions
- Anticoagulants (blood thinners): Using Relafen with blood thinners like warfarin or aspirin may increase the risk of bleeding.
- Other NSAIDs: Taking Relafen with other NSAIDs (e.g., ibuprofen or naproxen) increases the risk of gastrointestinal bleeding and kidney problems.
- Diuretics and ACE inhibitors: Relafen may reduce the effectiveness of certain blood pressure medications, such as diuretics or ACE inhibitors, and increase the risk of kidney problems.
- Corticosteroids: Concurrent use of corticosteroids with Relafen may increase the risk of gastrointestinal side effects.
Alternatives to Relafen
- Ibuprofen (Advil, Motrin): Another NSAID used for the relief of pain and inflammation.
- Celecoxib (Celebrex): A COX-2 inhibitor that provides anti-inflammatory effects with potentially fewer gastrointestinal side effects.
- Meloxicam (Mobic): Another NSAID used for the treatment of osteoarthritis and rheumatoid arthritis.
- Acetaminophen (Tylenol): A non-NSAID pain reliever that does not have anti-inflammatory properties but may be safer for individuals at risk of gastrointestinal side effects.
