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Pristiq
Pristiq (generic name: desvenlafaxine) is a prescription antidepressant that belongs to the class of serotonin-norepinephrine reuptake inhibitors (SNRIs). It is used to treat major depressive disorder (MDD) in adults by helping to restore the balance of neurotransmitters in the brain, specifically serotonin and norepinephrine. Pristiq can help improve mood, energy levels, and overall well-being in individuals suffering from depression.
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Frequently Asked Questions
How long does it take for Pristiq to start working?
Pristiq may take 2 to 4 weeks to start improving symptoms of depression, although some individuals may experience improvements sooner. Full effects may take up to 6 to 8 weeks.
Can Pristiq cause weight gain?
While weight changes are possible, Pristiq is generally associated with weight loss more often than weight gain. However, individual experiences may vary.
What should I do if I miss a dose of Pristiq?
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next scheduled dose. Do not double up on doses to make up for a missed one.
Can Pristiq be taken with other antidepressants?
Pristiq should not be taken with other antidepressants without the guidance of your healthcare provider, especially monoamine oxidase inhibitors (MAOIs), as this may increase the risk of serotonin syndrome.
Is Pristiq safe during pregnancy?
Pristiq should only be used during pregnancy if clearly needed. There may be risks associated with its use during pregnancy, especially in the third trimester. Discuss the potential risks and benefits with your doctor.
Comprehensive Drug Guide
How Does Pristiq Work?
Pristiq works by inhibiting the reuptake of serotonin and norepinephrine in the brain. These neurotransmitters play a key role in regulating mood and emotions. By increasing their availability, Pristiq helps reduce symptoms of depression, such as persistent sadness, lack of interest in daily activities, and fatigue. It also helps improve overall mood and cognitive function.
Common Dosages
- 25 mg extended-release tablets
- 50 mg extended-release tablets
- 100 mg extended-release tablets
Typical Dosing
- The usual starting dose of Pristiq is 50 mg once daily, taken with or without food.
- Depending on the patient's response, the dose may be increased to a maximum of 100 mg once daily.
- Pristiq tablets should be swallowed whole and should not be crushed, chewed, or split.
Typical Dosing
FDA Approved Indications
- Major Depressive Disorder (MDD) in adults.
Who Shouldn't Take Pristiq?
- Known hypersensitivity to desvenlafaxine, venlafaxine, or any component of the formulation.
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI due to the risk of serotonin syndrome.
Advice From The Pharmacist
- Take Pristiq at the same time each day, with or without food. If you experience nausea, taking it with food may help.
- Swallow the tablet whole; do not crush, chew, or split it, as this can affect how the medication is absorbed.
- It may take several weeks before you start to notice an improvement in your symptoms. Continue taking the medication as prescribed, even if you feel better, unless advised otherwise by your healthcare provider.
- Do not stop taking Pristiq suddenly, as this can lead to withdrawal symptoms such as irritability, dizziness, nausea, or headache. Always follow your doctor’s instructions for tapering off the medication.
- Store Pristiq at room temperature, away from moisture and heat.
Side Effects of Pristiq
Common Side Effects
- Nausea
- Dizziness
- Dry mouth
- Increased sweating
- Constipation
- Decreased appetite
Uncommon/Severe Side Effects
- Serotonin syndrome, characterized by symptoms such as confusion, agitation, rapid heart rate, high blood pressure, and muscle stiffness.
- Increased risk of suicidal thoughts or behaviors, especially in young adults, adolescents, and children.
- Elevated blood pressure or heart rate, which may require monitoring.
- Seizures in individuals with a history of seizure disorders.
Risks and Warnings of Pristiq
- Serotonin Syndrome: The combination of Pristiq with other serotonergic medications, such as other antidepressants, triptans, or certain pain medications, can increase the risk of serotonin syndrome. Symptoms include agitation, confusion, sweating, rapid heart rate, and muscle twitching. Seek medical attention immediately if these symptoms occur.
- Blood Pressure Elevation: Pristiq may raise blood pressure in some individuals, especially at higher doses. Regular blood pressure monitoring is recommended, particularly in patients with a history of hypertension.
- Increased Risk of Suicidal Thoughts: Like other antidepressants, Pristiq may increase the risk of suicidal thoughts and behaviors in adolescents, young adults, and children. Close monitoring is important during the early stages of treatment.
- Discontinuation Syndrome: Abruptly stopping Pristiq may lead to withdrawal symptoms, including irritability, nausea, dizziness, and fatigue. Gradual dose reduction under medical supervision is recommended.
Interactions with Pristiq
Common Drug Interactions
- MAO inhibitors: Taking Pristiq with monoamine oxidase inhibitors (MAOIs) can lead to serious interactions, including serotonin syndrome. Allow at least 14 days between stopping an MAOI and starting Pristiq.
- Other serotonergic drugs: Combining Pristiq with other drugs that increase serotonin levels, such as SSRIs, triptans, or tramadol, can increase the risk of serotonin syndrome.
- NSAIDs or blood thinners: Pristiq may increase the risk of bleeding when taken with nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, or anticoagulants like warfarin.
- Alcohol: Drinking alcohol while taking Pristiq can increase the risk of side effects, such as dizziness and impaired cognitive function.
Alternatives to Pristiq
- Effexor XR (venlafaxine): Another SNRI that is used to treat depression, anxiety, and panic disorders.
- Cymbalta (duloxetine): An SNRI used for depression, anxiety, and chronic pain management.
- Zoloft (sertraline): A selective serotonin reuptake inhibitor (SSRI) used for depression and anxiety.
- Lexapro (escitalopram): An SSRI used to treat depression and generalized anxiety disorder.
