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niMODipine
Nimodipine is a type of medication known as a calcium channel blocker. It's specifically designed to reduce the severity and duration of ischemic deficits in adult patients following a subarachnoid hemorrhage (bleeding into the space surrounding the brain). Some common side effects include headache, nausea, or general discomfort, but your doctor will usually make sure the benefits outweigh these issues.
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Frequently Asked Questions
Can I stop taking Nimodipine on my own?
Don't stop taking nimodipine without talking to your doctor first. Stopping suddenly may make your condition worse or cause a heart attack.
Can I take Nimodipine if I have liver problems?
It's generally not recommended if you have severe liver problems. Talk to your doctor about alternative treatments.
What should I do if I miss a dose?
Take it as soon as you can, but if it's almost time for your next dose, skip the one you missed. Do not take double or extra doses.
Will Nimodipine treat my headache?
Nimodipine is not a headache medicine. It's used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm.
Comprehensive Drug Guide
How Does niMODipine Work?
Nimodipine is a dihydropyridine calcium channel blocker. It inhibits the influx of extracellular calcium ions into myocardial and smooth muscle cells, preventing muscle contraction and thereby dilating coronary and systemic arteries.
What is niMODipine Used For?
FDA indications: Nimodipine is used to improve neurological outcomes following subarachnoid hemorrhage.
Offlabel uses: It's also been used for the offlabel treatment of cerebral vasospasm and ischemic strokes.
Common Dosages
Tablets: 30mg
Oral solution: 10mg/mL
Typical Dosing
FDA Approved Indications
- For FDAapproved indications:
- Subarachnoid Hemorrhage: 60mg every 4 hours
Off-Label Uses
- For offlabel uses:
- Cerebral Vasospasm: 30 to 120mg every 2 to 4 hours
Who Shouldn't Take niMODipine?
- Have severe liver problems.
- Have had an allergic reaction to a class of medicines known as dihydropyridines.
- Are currently taking strong inhibitors of CYP3A4 (like some antifungal medication)
Advice From The Pharmacist
- Take this medication with a full glass of water.
- Your doctor might advise you to avoid eating grapefruits or drinking grapefruit juice while taking this medication; it can increase the amount of nimodipine in your blood.
- Your blood pressure should be closely monitored while on this medication.
- Avoid consuming alcohol, as it can increase certain side effects of nimodipine
Side Effects of niMODipine
Common Side Effects
- You may feel dizzy or lightheaded, or have a slower heart rate.
- You might endure nausea or diarrhea.
- You might experience sweating or flushing.
Uncommon/Severe Side Effects
- Rare side effects:
- You may experience difficulty in breathing or wheezing.
- Severe side effects:
- If your heartbeat is fast or uneven contact your doctor right away.
- If you experience swelling in your ankles or feet seek immediate attention.
- If you have symptoms of liver problems such as dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, and yellowing eyes/skin, get medical help immediately.
Risks and Warnings of niMODipine
- Remember that Nimodipine, despite its many benefits, is not for everyone. It can lead to troubling side effects in certain situations and should not be used if you have severe liver problems or a previous allergic reaction to a class of medications known as dihydropyridines.
- If you're currently taking strong inhibitors of CYP3A4 (like some types of antifungal medication), avoid taking nimodipine.
- Blood pressure issues? Nimodipine can lower blood pressure, hence should be used with caution if you're suffering from low blood pressure.
- To folks with heart issues such as angina or heart failure, tread carefully. Nimodipine can trigger or worsen these conditions.
Interactions with niMODipine
Common Drug Interactions
- Rifampin
- St. John's Wort
- CYP3A4 inhibitors (like ketoconazole, itraconazole, and some types of antibiotics).
Alternatives to niMODipine
- Amlodipine
- Felodipine
- Nifedipine
- Diltiazem
- Verapamil
