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Naprelan
Naprelan, the brand name for naproxen sodium, is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and swelling. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, tendinitis, and bursitis. It is also effective for treating acute pain such as muscle strains, sprains, and menstrual cramps. Naprelan provides extended pain relief with a once-daily dosing option due to its extended-release formulation.
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Frequently Asked Questions
How long does it take for Naprelan to start working?
Naprelan typically begins to relieve pain within 1 hour after the first dose. Its extended-release formulation provides consistent pain relief for up to 24 hours.
Can I take Naprelan long-term?
Naprelan can be taken long-term for conditions like arthritis, but regular monitoring by your healthcare provider is important due to the risk of side effects such as gastrointestinal bleeding, heart attack, or kidney problems.
Can I take Naprelan with other pain relievers?
You should avoid taking Naprelan with other NSAIDs (e.g., ibuprofen or aspirin) to reduce the risk of gastrointestinal bleeding. However, it may be safe to take acetaminophen (Tylenol) with Naprelan for additional pain relief. Always check with your healthcare provider before combining medications.
What should I do if I miss a dose of Naprelan?
If you miss a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for a missed one.
Can I drink alcohol while taking Naprelan?
It is best to avoid alcohol while taking Naprelan, as alcohol can increase the risk of gastrointestinal bleeding.
Comprehensive Drug Guide
How Does Naprelan Work?
Naprelan (naproxen sodium) works by inhibiting the activity of the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, substances that cause inflammation, pain, and fever. By blocking COX enzymes, Naprelan reduces the production of prostaglandins, resulting in decreased inflammation and pain. Its extended-release formulation allows for consistent and prolonged pain relief throughout the day.
Common Dosages
- 375 mg extended-release tablets
- 500 mg extended-release tablets
- 750 mg extended-release tablets
Typical Dosing
- For arthritis (osteoarthritis, rheumatoid arthritis, ankylosing spondylitis): The typical dose is 750 mg to 1000 mg once daily. Some patients may require an additional dose of 250 mg to 500 mg if necessary.
- For acute pain and menstrual cramps: The typical starting dose is 500 mg to 1000 mg once daily, with an additional 250 mg if needed, but not exceeding 1250 mg per day.
Dosing may vary depending on the patient's condition, and it should always be taken as directed by a healthcare provider.
Typical Dosing
FDA Approved Indications
- Treatment of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
- Management of acute pain due to muscle strains, sprains, tendinitis, bursitis, and menstrual cramps.
- Treatment of gout attacks.
Who Shouldn't Take Naprelan?
- Allergy to naproxen or other NSAIDs (e.g., aspirin).
- Active gastrointestinal bleeding or a history of peptic ulcers.
- Severe kidney or liver impairment.
- History of asthma, urticaria, or allergic-type reactions after taking NSAIDs.
- Coronary artery bypass graft (CABG) surgery: Naprelan should not be used in the peri-operative period of CABG due to an increased risk of cardiovascular events.
Advice From The Pharmacist
- Take Naprelan with food or milk to minimize the risk of stomach upset or gastrointestinal side effects.
- Do not exceed the prescribed dose. Taking higher doses increases the risk of serious side effects, including gastrointestinal bleeding, heart attack, and stroke.
- Avoid alcohol while taking Naprelan, as it can increase the risk of stomach bleeding.
- If you are using blood thinners (e.g., warfarin), talk to your healthcare provider before using Naprelan, as NSAIDs can increase the risk of bleeding.
- Monitor for gastrointestinal symptoms such as stomach pain, black or tarry stools, or vomiting blood, and seek medical attention if these occur.
Side Effects of Naprelan
Common Side Effects
- Stomach pain or discomfort
- Nausea
- Heartburn
- Headache
- Dizziness or drowsiness
Uncommon/Severe Side Effects
- Gastrointestinal bleeding: Symptoms include black or tarry stools, vomiting blood, or severe stomach pain.
- Heart attack or stroke: NSAIDs may increase the risk of cardiovascular events, especially in people with heart disease or long-term use.
- Kidney problems: Symptoms include reduced urination, swelling in the legs or feet, and unusual fatigue.
Risks and Warnings of Naprelan
- Gastrointestinal risks: Naprelan increases the risk of gastrointestinal bleeding, ulcers, and perforation of the stomach or intestines. These effects can occur without warning, particularly in older adults or those with a history of gastrointestinal issues.
- Cardiovascular risks: Naprelan can increase the risk of heart attack or stroke, particularly in individuals with cardiovascular disease or risk factors such as high blood pressure or smoking.
- Kidney and liver impairment: Long-term use of NSAIDs can affect kidney and liver function. Patients with pre-existing kidney or liver disease should be closely monitored.
- Use in the elderly: Older adults may be more sensitive to the side effects of Naprelan, particularly gastrointestinal bleeding and kidney issues.
Interactions with Naprelan
Common Drug Interactions
- Anticoagulants (blood thinners): Naprelan can increase the risk of bleeding when used with blood thinners like warfarin or aspirin.
- Other NSAIDs: Combining Naprelan with other NSAIDs (e.g., ibuprofen or aspirin) increases the risk of gastrointestinal side effects and kidney problems.
- ACE inhibitors and diuretics: Naprelan may reduce the effectiveness of certain blood pressure medications, including ACE inhibitors and diuretics, and increase the risk of kidney problems.
- Corticosteroids: Taking corticosteroids with Naprelan may increase the risk of gastrointestinal bleeding.
Alternatives to Naprelan
- Ibuprofen (Advil, Motrin): Another NSAID used for pain relief, inflammation, and fever reduction.
- Celecoxib (Celebrex): A selective COX-2 inhibitor that provides anti-inflammatory effects with fewer gastrointestinal side effects.
- Meloxicam (Mobic): Another NSAID often prescribed for long-term management of arthritis symptoms.
- Acetaminophen (Tylenol): A non-NSAID pain reliever that may be safer for individuals at risk of gastrointestinal side effects.
