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Monurol
Monurol, the brand name for fosfomycin, is an antibiotic used primarily for the treatment of urinary tract infections (UTIs), specifically acute uncomplicated cystitis in women caused by certain bacteria such as Escherichia coli (E. coli) and Enterococcus faecalis. It works by killing the bacteria responsible for the infection. Monurol is unique in that it is typically given as a single-dose treatment, making it convenient for patients.
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Frequently Asked Questions
How long does it take for Monurol to work?
Monurol typically starts working within 24-48 hours. Symptom relief may begin within this time frame, but complete symptom resolution may take up to 3 days.
Can I take Monurol with food?
It is recommended to take Monurol on an empty stomach for better absorption. Taking it with food may reduce its effectiveness.
What should I do if I still have symptoms after taking Monurol?
If your symptoms persist or worsen after 3 days, contact your healthcare provider. Additional treatment may be necessary, as Monurol may not cover all bacteria causing UTIs.
Is Monurol safe for use during pregnancy?
Monurol is classified as pregnancy category B, meaning it is generally considered safe during pregnancy. However, always consult with your healthcare provider before taking any medication during pregnancy.
Can Monurol treat complicated UTIs?
Monurol is primarily used for acute uncomplicated cystitis in women. It is not typically recommended for complicated UTIs or infections involving the kidneys (pyelonephritis). Consult your healthcare provider for appropriate treatment in these cases.
Comprehensive Drug Guide
How Does Monurol Work?
Monurol (fosfomycin) works by inhibiting the bacterial enzyme enolpyruvyl transferase, which is necessary for the synthesis of the bacterial cell wall. By disrupting the cell wall, fosfomycin kills the bacteria, effectively treating the infection. It is bactericidal (kills bacteria), and its unique mechanism of action makes it effective against bacteria that may be resistant to other antibiotics.
Common Dosages
- 3 g single-dose sachet
Typical Dosing
- The standard dose of Monurol is 3 grams (one sachet) taken as a single dose.
- To administer, dissolve the contents of the sachet in 3-4 ounces of water (do not use hot water), stir, and drink immediately. It is typically taken once and does not require a prolonged course of treatment.
Typical Dosing
FDA Approved Indications
- Treatment of acute uncomplicated urinary tract infections (cystitis) in women caused by susceptible strains of Escherichia coli and Enterococcus faecalis.
Who Shouldn't Take Monurol?
- Known hypersensitivity or allergy to fosfomycin or any component of the formulation.
- Severe renal impairment or those undergoing hemodialysis, as the drug may not be cleared properly from the body.
Advice From The Pharmacist
- Take Monurol on an empty stomach or at least 2-3 hours after a meal for better absorption. Avoid taking it with food, as food may reduce its effectiveness.
- Dissolve the entire sachet in water and drink immediately after mixing. Do not take it dry or without diluting it first.
- Complete the entire course (one dose). There is no need for follow-up doses unless instructed by your healthcare provider.
- If you experience symptoms of a recurring UTI after completing Monurol, consult your healthcare provider, as additional treatment may be necessary.
Side Effects of Monurol
Common Side Effects
- Diarrhea
- Nausea
- Headache
- Vaginitis (inflammation of the vagina)
- Stomach upset
Uncommon/Severe Side Effects
- Severe allergic reactions: Rash, itching, swelling, or difficulty breathing.
- Clostridioides difficile-associated diarrhea: Severe diarrhea that may occur after antibiotic use.
Risks and Warnings of Monurol
- Allergic reactions: Monurol may cause allergic reactions, especially in individuals who have had reactions to other antibiotics. Seek medical attention if you experience any symptoms of an allergic reaction.
- Superinfection: Prolonged use of antibiotics, including Monurol, can lead to the development of drug-resistant bacteria or fungal infections. If symptoms worsen or new infections develop, contact your healthcare provider.
Interactions with Monurol
Common Drug Interactions
- Metoclopramide: This drug, used to treat nausea and gastroparesis, can reduce the absorption of fosfomycin, lowering its effectiveness. Avoid using metoclopramide around the time of taking Monurol.
- Antacids: Antacids containing calcium, magnesium, or aluminum may reduce the effectiveness of fosfomycin. It's best to avoid taking antacids around the same time as Monurol.
Alternatives to Monurol
- Nitrofurantoin (Macrobid): Another commonly used antibiotic for treating uncomplicated UTIs.
- Trimethoprim-sulfamethoxazole (Bactrim): A combination antibiotic used for UTIs but may not be effective against resistant bacteria.
- Ciprofloxacin (Cipro): A fluoroquinolone antibiotic used to treat complicated and uncomplicated UTIs.
