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Gloperba
Gloperba (colchicine oral solution) is a medication used to treat gout flares and manage familial Mediterranean fever. Colchicine works by decreasing inflammation, thereby relieving pain and swelling associated with gout attacks. It is also effective in preventing attacks in patients with a history of recurrent gout.
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Frequently Asked Questions
How quickly does Gloperba work for gout flares?
Patients may notice relief within hours after the initial dose, but individual responses can vary.
Can I take Gloperba if I am pregnant?
Consult your healthcare provider for guidance if you are pregnant or planning to become pregnant, as the benefits must be weighed against potential risks.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember unless it is almost time for your next scheduled dose. Do not double up on doses.
Are there any specific storage instructions for Gloperba?
Store at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
Is Gloperba safe for long-term use?
While effective for managing gout, long-term use should be monitored by a healthcare provider to prevent potential side effects.
Comprehensive Drug Guide
How Does Gloperba Work?
Gloperba works by inhibiting the migration of leukocytes to inflamed areas and disrupting the inflammatory process associated with gout attacks. By reducing the inflammatory response, colchicine alleviates the symptoms of pain and swelling.
Common Dosages
Gloperba is available in the following form:
- Oral solution: Typically available in a concentration of 0.6 mg per 5 mL.
Typical Dosing
The typical dosing for Gloperba is:
- For Acute Gout Flares: The initial dose is usually 1.2 mg (10 mL) at the first sign of a flare, followed by 0.6 mg (5 mL) one hour later if needed. The maximum dose should not exceed 1.8 mg in one hour.
- For Prophylaxis: The dose may be adjusted based on the patient's history and response.
Typical Dosing
FDA Approved Indications
- Treatment of acute gout flares.
- Prophylaxis of gout flares in patients with a history of recurrent gout.
- Management of familial Mediterranean fever.
Who Shouldn't Take Gloperba?
- Hypersensitivity: Known hypersensitivity to colchicine or any components of the formulation.
- Severe Renal or Hepatic Impairment: Use with caution and under medical supervision in patients with significant renal or liver disease.
Advice From The Pharmacist
- How to Take: Measure the dose carefully using the provided dosing syringe. Shake the bottle well before use to ensure proper mixing.
- Monitor Symptoms: Keep track of any side effects, particularly gastrointestinal symptoms such as diarrhea, and report them to your healthcare provider.
- Avoid Grapefruit: Grapefruit and grapefruit juice may interact with colchicine and increase the risk of side effects.
Side Effects of Gloperba
Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
Uncommon/Severe Side Effects
- Myopathy or neuropathy: Rare but serious muscle or nerve issues.
- Severe allergic reactions: Such as rash, itching, or difficulty breathing.
Risks and Warnings of Gloperba
- Gastrointestinal Issues: Diarrhea is common; if severe, consider contacting a healthcare provider for possible dose adjustment.
- Drug Interactions: Be cautious with other medications that can affect liver metabolism, as they may increase colchicine levels.
Interactions with Gloperba
Common Drug Interactions
- Drug Interactions: Inform your healthcare provider about all medications you are taking, especially those affecting CYP3A4 and P-glycoprotein.
- Food Interactions: Avoid grapefruit products while taking Gloperba, as they can increase the risk of side effects.
Alternatives to Gloperba
- Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Such as ibuprofen or naproxen.
- Other Antigout Medications: Such as allopurinol for long-term management of uric acid levels.
