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Fesoterodine Fumarate ER
Fesoterodine Fumarate ER is a medication used to treat overactive bladder (OAB), characterized by symptoms such as urinary urgency, frequency, and urge incontinence (leakage). It belongs to a class of drugs known as anticholinergics or antimuscarinics, which work by relaxing the muscles of the bladder to reduce spasms, thereby increasing the bladder's capacity to hold urine and decreasing the frequency and urgency of urination. The extended-release (ER) formulation ensures a gradual release of the medication throughout the day, allowing for once-daily dosing.
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Frequently Asked Questions
How long does it take for Fesoterodine Fumarate ER to work?
It may take 1 to 2 weeks for symptoms to improve, with full benefits usually seen after 8 weeks of continuous use.
Can I stop taking Fesoterodine Fumarate ER if I feel better?
No, it is important to continue taking the medication as prescribed to maintain symptom control. Stopping the medication may lead to a return of overactive bladder symptoms.
What should I do if I miss a dose of Fesoterodine?
Take the missed dose as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double up on doses.
Can Fesoterodine Fumarate ER cause dry mouth?
Yes, dry mouth is a common side effect of fesoterodine. Sipping water, using sugar-free gum, or using lozenges may help alleviate the discomfort.
Is Fesoterodine safe for older adults?
While Fesoterodine is generally safe for older adults, it may increase the risk of cognitive impairment and urinary retention. Close monitoring by a healthcare provider is recommended for elderly patients.
Comprehensive Drug Guide
How Does Fesoterodine Fumarate ER Work?
Fesoterodine works by blocking muscarinic receptors in the bladder, which reduces involuntary bladder contractions. By relaxing the bladder muscles, it increases bladder capacity and delays the urge to urinate. This action helps to relieve symptoms of overactive bladder, such as frequent urination, urgency, and incontinence.
Common Dosages
For overactive bladder: Start with 4 mg once daily, with the option to increase to 8 mg once daily if needed. Fesoterodine ER should be taken with water, and the tablet should be swallowed whole—do not crush or chew the tablet.
Typical Dosing
FDA Approved Indications
- Overactive bladder (OAB) with symptoms of urinary urgency, frequency, and urge incontinence.
Who Shouldn't Take Fesoterodine Fumarate ER?
- Urinary retention.
- Gastrointestinal obstruction (e.g., paralytic ileus).
- Uncontrolled narrow-angle glaucoma.
- Known hypersensitivity to fesoterodine or its ingredients.
Advice From The Pharmacist
- Take Fesoterodine Fumarate ER once daily, with or without food, and try to take it at the same time each day.
- Do not crush or chew the extended-release tablets, as this can interfere with the medication's release mechanism.
- If you experience dry mouth, which is a common side effect, try sipping water throughout the day or using sugar-free lozenges to keep your mouth moist.
- Avoid alcohol while taking this medication, as it may increase drowsiness or dizziness.
- Monitor for urinary retention, especially if you already have difficulty emptying your bladder. Inform your doctor if you notice a significant decrease in urination.
Side Effects of Fesoterodine Fumarate ER
Common Side Effects
- Dry mouth
- Constipation
- Blurred vision
- Drowsiness
- Dizziness
- Dry eyes
Uncommon/Severe Side Effects
- Severe allergic reactions (swelling of the face, lips, or throat, difficulty breathing).
- Urinary retention, where the bladder cannot empty fully.
- Severe constipation.
- Cognitive impairment, especially in older adults, as anticholinergics can cause confusion or memory issues.
Risks and Warnings of Fesoterodine Fumarate ER
- Urinary Retention: Fesoterodine can cause or worsen urinary retention, especially in patients with existing bladder outflow obstruction.
- Cognitive Impairment: Anticholinergics, including fesoterodine, can cause confusion, drowsiness, and memory problems, especially in older adults. Patients should be monitored for changes in cognitive function.
- Heat Prostration: Fesoterodine may reduce sweating, leading to an increased risk of heat prostration in hot weather or during exercise. Stay hydrated and avoid overheating.
Interactions with Fesoterodine Fumarate ER
Common Drug Interactions
- Other anticholinergic medications: Combining fesoterodine with other anticholinergic drugs can increase the risk of side effects, such as dry mouth, constipation, or confusion.
- CYP3A4 inhibitors: Medications such as ketoconazole, itraconazole, or clarithromycin can increase the levels of fesoterodine in the blood, raising the risk of side effects. Your doctor may lower your dose if you're taking these medications.
- Alcohol: May increase the risk of drowsiness or dizziness when combined with fesoterodine.
Alternatives to Fesoterodine Fumarate ER
- Tolterodine (Detrol LA): Another antimuscarinic medication used for overactive bladder, available in extended-release form.
- Oxybutynin (Ditropan XL): An antimuscarinic that can be used for overactive bladder.
- Solifenacin (Vesicare): An antimuscarinic with a similar mechanism to fesoterodine, used for managing overactive bladder.
- Mirabegron (Myrbetriq): A beta-3 adrenergic agonist that treats overactive bladder by relaxing bladder muscles but does not have anticholinergic side effects.
