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Fenoprofen Calcium
Fenoprofen Calcium is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and swelling associated with conditions like osteoarthritis, rheumatoid arthritis, and acute musculoskeletal pain. It works by reducing the production of chemicals in the body that cause inflammation and pain. Fenoprofen is often used to provide relief from mild to moderate pain and to help manage chronic conditions involving joint inflammation.
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Frequently Asked Questions
How long does it take for Fenoprofen to work?
Fenoprofen typically starts to relieve pain and inflammation within 30 to 60 minutes of taking the medication.
Can I take Fenoprofen with other pain relievers?
You can take Fenoprofen with acetaminophen (Tylenol), but avoid taking it with other NSAIDs like ibuprofen or naproxen, as this increases the risk of gastrointestinal bleeding.
What should I do if I miss a dose of Fenoprofen?
If you miss a dose, take it as soon as you remember. If it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Is Fenoprofen safe for long-term use?
Long-term use of fenoprofen is associated with an increased risk of cardiovascular events, kidney damage, and gastrointestinal bleeding. It is important to use the lowest effective dose for the shortest duration possible, and to undergo regular monitoring if used long-term.
Can I take Fenoprofen if I have high blood pressure?
Fenoprofen, like other NSAIDs, may increase blood pressure and should be used with caution in patients with hypertension. Consult your healthcare provider if you have high blood pressure before starting fenoprofen.
Comprehensive Drug Guide
How Does Fenoprofen Calcium Work?
Fenoprofen works by inhibiting the enzyme cyclooxygenase (COX), specifically COX-1 and COX-2, which are responsible for producing prostaglandins—chemicals that cause inflammation, pain, and fever. By blocking the production of prostaglandins, fenoprofen reduces inflammation, alleviates pain, and lowers fever.
What is Fenoprofen Calcium Used For?
Common Dosages
The typical dosage for Fenoprofen Calcium is:
- For arthritis (osteoarthritis or rheumatoid arthritis): The usual dose is 400 mg to 600 mg three or four times daily, depending on the severity of the condition and the patient’s response to the medication.
- For mild to moderate pain: The usual dose is 200 mg to 400 mg every 4 to 6 hours, as needed.
Typical Dosing
- For arthritis: The standard dose is 400 mg to 600 mg three or four times a day, taken with food or milk to reduce the risk of stomach upset.
- For acute pain: The dose is 200 mg to 400 mg every 4 to 6 hours, not exceeding a total daily dose of 2400 mg.
Typical Dosing
FDA Approved Indications
- Osteoarthritis: To relieve the pain, swelling, and stiffness associated with joint inflammation.
- Rheumatoid arthritis: For reducing inflammation and pain in joints affected by rheumatoid arthritis.
- Mild to moderate pain: For treating pain due to musculoskeletal conditions, such as strains, sprains, or other acute injuries.
Off-Label Uses
Who Shouldn't Take Fenoprofen Calcium?
- Known hypersensitivity to fenoprofen or any other NSAID.
- Active gastrointestinal bleeding, peptic ulcers, or a history of gastrointestinal perforation or bleeding.
- Severe kidney disease.
- Coronary artery bypass graft (CABG) surgery, as NSAIDs are contraindicated for the management of perioperative pain in this setting.
- Asthma, hives, or allergic reactions triggered by aspirin or other NSAIDs.
Advice From The Pharmacist
- Take fenoprofen with food or milk to reduce the risk of stomach upset or gastrointestinal irritation.
- Avoid alcohol while taking fenoprofen, as it can increase the risk of stomach bleeding.
- Fenoprofen may increase the risk of heart attack, stroke, or gastrointestinal bleeding, especially if used long-term. Use the lowest effective dose for the shortest duration necessary.
- If you experience unexplained stomach pain, black stools, or vomiting blood, seek medical attention immediately.
- Fenoprofen can cause fluid retention and swelling; inform your healthcare provider if you notice swelling in your hands or feet, or if you have difficulty breathing.
Side Effects of Fenoprofen Calcium
Common Side Effects
- Nausea
- Heartburn
- Stomach pain
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding (bloody or black stools, vomiting blood)
- Liver damage (yellowing of the skin or eyes, dark urine, fatigue)
- Kidney problems (reduced urination, swelling, fatigue)
- Heart attack or stroke (chest pain, shortness of breath, weakness on one side of the body)
- Severe allergic reactions (rash, hives, difficulty breathing)
Risks and Warnings of Fenoprofen Calcium
- Gastrointestinal Risk: Fenoprofen increases the risk of serious gastrointestinal adverse events, including bleeding, ulceration, and perforation of the stomach or intestines. These events can occur at any time during use and without warning. Elderly patients are at higher risk for these serious gastrointestinal events.
- Cardiovascular Risk: NSAIDs like fenoprofen increase the risk of serious cardiovascular events, including heart attack and stroke, especially with prolonged use or in patients with existing heart disease.
- Kidney Risk: Fenoprofen can cause kidney damage, especially in individuals with pre-existing kidney problems or in those taking other medications that affect the kidneys (e.g., diuretics, ACE inhibitors).
- Liver Toxicity: Regular monitoring of liver function is recommended, as fenoprofen can cause liver damage in some individuals.
Interactions with Fenoprofen Calcium
Common Drug Interactions
- Anticoagulants (e.g., warfarin): Fenoprofen can increase the risk of bleeding when taken with blood thinners.
- Other NSAIDs or aspirin: Combining fenoprofen with other NSAIDs or aspirin can increase the risk of gastrointestinal bleeding.
- Diuretics (e.g., furosemide): Fenoprofen may reduce the effectiveness of diuretics and other blood pressure medications, leading to fluid retention or worsening of kidney function.
- Corticosteroids (e.g., prednisone): Concomitant use with corticosteroids can increase the risk of gastrointestinal side effects.
Alternatives to Fenoprofen Calcium
- Ibuprofen (Advil, Motrin): A commonly used NSAID that treats pain and inflammation.
- Naproxen (Aleve): Another NSAID used to treat pain and inflammation with a longer duration of action compared to ibuprofen.
- Celecoxib (Celebrex): A COX-2 inhibitor that may have fewer gastrointestinal side effects compared to non-selective NSAIDs like fenoprofen.
- Acetaminophen (Tylenol): An alternative for pain relief without anti-inflammatory effects, often used in patients who cannot tolerate NSAIDs.
