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Etodolac ER
Etodolac ER (extended-release) is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and decrease swelling in various conditions such as osteoarthritis and rheumatoid arthritis. By blocking the production of prostaglandins (chemicals that cause inflammation), Etodolac ER helps to manage chronic pain and inflammatory conditions, making it easier for patients to move and function.
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Frequently Asked Questions
How long does it take for Etodolac ER to work?
You may start to feel pain relief within a few hours of taking Etodolac ER, but full anti-inflammatory effects may take up to a week of regular use.
Can I take Etodolac ER long-term?
Etodolac ER can be used long-term under the supervision of a healthcare provider. However, long-term use increases the risk of gastrointestinal issues, heart problems, and kidney damage. Regular monitoring by your doctor is recommended.
What should I do if I miss a dose of Etodolac ER?
Take the missed dose as soon as you remember, unless it’s almost time for the next dose. If it’s close to the next dose, skip the missed dose and continue with your regular schedule. Do not double up doses to make up for the missed one.
Can I take Etodolac ER with other pain relievers?
Avoid taking other NSAIDs or aspirin with Etodolac ER, as this increases the risk of side effects. However, acetaminophen (Tylenol) can be taken with Etodolac ER, as it works differently and doesn’t increase the risk of gastrointestinal bleeding.
Is Etodolac ER safe for people with heart disease?
People with heart disease should use Etodolac ER cautiously, as NSAIDs can increase the risk of heart attack or stroke. Consult your healthcare provider to discuss the risks and benefits before starting this medication.
Comprehensive Drug Guide
How Does Etodolac ER Work?
Etodolac ER works by inhibiting the enzyme cyclooxygenase (COX), specifically COX-2, which is involved in the production of prostaglandins. Prostaglandins are responsible for causing inflammation, pain, and fever. By blocking COX-2, etodolac reduces inflammation and pain while helping to restore normal function and mobility.
Common Dosages
- Adults: The usual dose for managing arthritis is 400 mg to 1000 mg once daily, depending on the severity of the condition. Higher doses should be used with caution to avoid potential side effects.
- Elderly patients: May require a lower starting dose due to increased risk of side effects like gastrointestinal bleeding or kidney issues.
Typical Dosing
FDA Approved Indications
- Osteoarthritis: To reduce pain and inflammation in joints.
- Rheumatoid arthritis: For managing pain and swelling associated with this autoimmune condition.
- Chronic pain: Management of long-term musculoskeletal pain.
Off-Label Uses
- Known hypersensitivity to etodolac, aspirin, or other NSAIDs.
- History of asthma, urticaria, or allergic-type reactions after taking NSAIDs or aspirin.
- Active gastrointestinal bleeding or peptic ulcers.
- Severe kidney or liver disease.
- Heart failure or recent heart attack.
Pediatric Dosing
Advice From The Pharmacist
- Take Etodolac ER with food or milk to reduce the risk of stomach upset or gastrointestinal irritation.
- Do not crush or chew the extended-release tablets, as this will interfere with the time-release mechanism and may cause more side effects.
- Avoid alcohol while taking this medication, as it increases the risk of gastrointestinal bleeding.
- Inform your healthcare provider if you experience any signs of gastrointestinal bleeding (e.g., black or bloody stools, vomiting blood), as this is a serious side effect of NSAIDs.
- Patients with a history of heart disease should use this medication cautiously and under the supervision of a healthcare provider, as NSAIDs can increase the risk of heart attack or stroke, particularly with long-term use.
Side Effects of Etodolac ER
Common Side Effects
- Stomach pain or discomfort
- Nausea
- Diarrhea or constipation
- Dizziness
- Headache
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulcers (black or bloody stools, vomiting blood)
- Heart attack or stroke (chest pain, shortness of breath, weakness on one side of the body)
- Kidney problems (changes in urination, swelling in feet or ankles)
- Severe allergic reactions (hives, swelling of the face or throat, difficulty breathing)
Risks and Warnings of Etodolac ER
- Gastrointestinal Risk: Long-term use of NSAIDs, including Etodolac ER, can lead to stomach ulcers or gastrointestinal bleeding, especially in older adults or those with a history of ulcers.
- Cardiovascular Risk: NSAIDs may increase the risk of heart attack or stroke, particularly with prolonged use or in individuals with pre-existing heart conditions.
- Kidney Damage: NSAIDs can reduce blood flow to the kidneys, leading to kidney problems, especially in patients with pre-existing kidney disease or those taking other nephrotoxic medications.
- Liver Toxicity: Rarely, Etodolac ER can cause liver damage. Symptoms of liver problems include yellowing of the skin or eyes (jaundice), dark urine, and upper abdominal pain.
Interactions with Etodolac ER
Common Drug Interactions
- Anticoagulants (e.g., warfarin): Etodolac may increase the risk of bleeding when taken with blood thinners.
- Other NSAIDs or aspirin: Avoid taking multiple NSAIDs together, as this increases the risk of gastrointestinal bleeding.
- Corticosteroids: Concomitant use may further increase the risk of gastrointestinal issues.
- Blood pressure medications: NSAIDs can reduce the effectiveness of ACE inhibitors, ARBs, or diuretics.
Alternatives to Etodolac ER
- Ibuprofen (Advil, Motrin): Another NSAID used to treat similar conditions, available in both OTC and prescription strengths.
- Naproxen (Aleve, Naprosyn): Another NSAID used to treat arthritis and pain.
- Celecoxib (Celebrex): A COX-2 selective NSAID that may have fewer gastrointestinal side effects compared to non-selective NSAIDs.
- Acetaminophen (Tylenol): An alternative for pain relief with less risk of gastrointestinal side effects, though it lacks anti-inflammatory properties.
