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EC-Naproxen
EC-Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation caused by various conditions, such as arthritis, muscle aches, tendonitis, bursitis, menstrual cramps, and gout. It works by reducing hormones that cause inflammation and pain in the body. The "EC" stands for enteric-coated, which means the medication is coated to prevent it from dissolving in the stomach, reducing the risk of stomach irritation. EC-Naproxen is often prescribed when long-term treatment is needed or for patients who are sensitive to stomach side effects from NSAIDs.
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Frequently Asked Questions
Can I take EC-Naproxen with food?
Yes, it is recommended to take EC-Naproxen with food or a full glass of water to reduce the risk of stomach upset.
How long does it take for EC-Naproxen to work?
EC-Naproxen may take 30 minutes to an hour to start relieving pain and inflammation.
Can I take EC-Naproxen with other NSAIDs like ibuprofen?
No, taking multiple NSAIDs at the same time increases the risk of gastrointestinal bleeding and other side effects.
Is EC-Naproxen safe for long-term use?
While EC-Naproxen can be used long-term for conditions like arthritis, it should be done under close medical supervision due to the risk of side effects such as gastrointestinal bleeding and kidney damage.
What should I do if I miss a dose?
If you miss a dose of EC-Naproxen, take it as soon as you remember, unless it is almost time for your next dose. Do not double up to make up for a missed dose.
Comprehensive Drug Guide
How Does EC-Naproxen Work?
EC-Naproxen works by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals in the body that cause inflammation, pain, and fever. By blocking these enzymes, EC-Naproxen reduces inflammation and pain in the affected areas.
Common Dosages
- 250 mg enteric-coated tablet
- 375 mg enteric-coated tablet
- 500 mg enteric-coated tablet
Typical Dosing
- For arthritis: The typical dose is 500 mg to 1000 mg per day, divided into two doses. For long-term use, the enteric-coated version is often used to minimize stomach irritation.
- For gout: The initial dose is typically 750 mg, followed by 250 mg every 8 hours until the attack subsides.
- For pain or menstrual cramps: A starting dose of 500 mg followed by 250 mg every 6-8 hours as needed is common.
Typical Dosing
FDA Approved Indications
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Gout
- Tendinitis and bursitis
- Dysmenorrhea (menstrual cramps)
- Mild to moderate pain such as from muscle aches, headaches, or toothaches
Who Shouldn't Take EC-Naproxen?
- Patients with aspirin-sensitive asthma or known allergy to NSAIDs
- Active stomach ulcers or history of gastrointestinal bleeding
- Severe kidney or liver impairment
- Patients undergoing coronary artery bypass graft (CABG) surgery
Advice From The Pharmacist
- Take EC-Naproxen with food or a full glass of water to reduce the risk of stomach upset.
- Do not crush or chew the enteric-coated tablets, as this can reduce the protective coating and increase stomach irritation.
- Avoid alcohol while taking this medication, as it can increase the risk of gastrointestinal bleeding.
- Monitor for signs of stomach ulcers, such as dark stools or stomach pain, and contact your healthcare provider if these occur.
- Do not take EC-Naproxen with other NSAIDs, such as ibuprofen, as this increases the risk of side effects.
Side Effects of EC-Naproxen
Common Side Effects
- Stomach upset, nausea, or heartburn
- Dizziness or headache
- Diarrhea or constipation
Uncommon/Severe Side Effects
- Gastrointestinal bleeding or ulcers
- Kidney damage with long-term use
- Increased risk of heart attack or stroke with prolonged use, particularly in higher doses
- Severe allergic reactions, including rash, swelling, or difficulty breathing
Risks and Warnings of EC-Naproxen
- Gastrointestinal Risks: Long-term use of EC-Naproxen, especially in higher doses, can increase the risk of stomach ulcers, bleeding, and perforation, which can be life-threatening. The enteric coating reduces but does not eliminate this risk.
- Cardiovascular Risks: Prolonged use of NSAIDs, including EC-Naproxen, may increase the risk of serious cardiovascular events like heart attack or stroke, particularly in those with preexisting heart conditions.
- Kidney Damage: NSAIDs can cause kidney damage over time, especially in patients with preexisting kidney conditions or those taking higher doses.
Interactions with EC-Naproxen
Common Drug Interactions
- Blood thinners (anticoagulants): Using EC-Naproxen with blood thinners like warfarin can increase the risk of bleeding.
- Corticosteroids: Combining NSAIDs with corticosteroids can increase the risk of gastrointestinal bleeding.
- Diuretics: NSAIDs can reduce the effectiveness of diuretics like furosemide and increase the risk of kidney problems.
- Antihypertensive drugs: NSAIDs may reduce the effectiveness of blood pressure medications, such as ACE inhibitors and beta-blockers.
Alternatives to EC-Naproxen
- Ibuprofen (Advil, Motrin): Another NSAID used for pain relief and inflammation.
- Meloxicam (Mobic): A once-daily NSAID with fewer gastrointestinal side effects in some patients.
- Celecoxib (Celebrex): A selective COX-2 inhibitor that is less likely to cause gastrointestinal issues than traditional NSAIDs.
- Acetaminophen (Tylenol): An over-the-counter pain reliever that does not have anti-inflammatory effects but is gentler on the stomach.
