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EC-Naprosyn

EC-Naprosyn (enteric-coated naproxen) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, inflammation, and fever associated with conditions like arthritis, musculoskeletal disorders, menstrual pain, and acute gout. The enteric coating allows the medication to pass through the stomach and be absorbed in the small intestine, which helps reduce stomach irritation often associated with NSAID use.



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Frequently Asked Questions

How long does it take for EC-Naprosyn to start working?
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Pain relief from EC-Naprosyn typically begins within 30 minutes to 1 hour after taking the medication. Full anti-inflammatory effects may take several days of consistent use.

Can I take EC-Naprosyn with food?
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Yes, EC-Naprosyn can be taken with food or milk to reduce the risk of stomach upset. The enteric coating is designed to protect the stomach, but taking it with food may provide additional protection.

What should I do if I miss a dose of EC-Naprosyn?
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If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose, skip the missed dose and take the next one as scheduled. Do not double up on doses.

Is EC-Naprosyn safe for long-term use?
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Long-term use of EC-Naprosyn may increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular events. It should only be used long-term under the supervision of a healthcare provider.

Can EC-Naprosyn be used for fever?
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Yes, EC-Naprosyn can be used to reduce fever, but it is primarily used for pain and inflammation. Always follow your healthcare provider's instructions for dosing and duration of use.

Comprehensive Drug Guide

How Does EC-Naprosyn Work?

EC-Naprosyn works by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are involved in the production of prostaglandins, chemicals responsible for pain, inflammation, and fever. By blocking these enzymes, EC-Naprosyn helps reduce inflammation and relieve pain.



Common Dosages

  • Enteric-coated tablets: 375 mg, 500 mg

Typical Dosing

  • For arthritis and chronic pain: The usual dose is 500 mg to 1,000 mg daily, divided into two doses (one dose every 12 hours).
  • For acute pain and menstrual cramps: 500 mg initially, followed by 250 mg every 6 to 8 hours as needed.

Typical Dosing

FDA Approved Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Acute gout
  • Mild to moderate pain
  • Menstrual pain


Who Shouldn't Take EC-Naprosyn?

  • Known hypersensitivity to naproxen or other NSAIDs
  • History of gastrointestinal bleeding or peptic ulcers
  • Severe liver or kidney impairment
  • Asthma triggered by NSAIDs


Advice From The Pharmacist

  • Take EC-Naprosyn with a full glass of water and avoid lying down for at least 10 minutes after taking it to prevent irritation of the esophagus.
  • Avoid taking EC-Naprosyn on an empty stomach. Although the enteric coating is designed to reduce stomach irritation, taking it with food or milk may help further minimize gastrointestinal discomfort.
  • Avoid alcohol while taking EC-Naprosyn, as it can increase the risk of stomach bleeding.
  • Do not exceed the recommended dose to prevent serious side effects such as gastrointestinal bleeding or kidney damage.


Side Effects of EC-Naprosyn

Common Side Effects

  • Nausea
  • Stomach pain
  • Heartburn
  • Headache
  • Dizziness


Uncommon/Severe Side Effects

  • Gastrointestinal bleeding (black stools, vomiting blood)
  • Severe allergic reactions (rash, swelling, difficulty breathing)
  • Kidney or liver damage (reduced urine output, jaundice)

Risks and Warnings of EC-Naprosyn

  • Gastrointestinal Risks: Although EC-Naprosyn is enteric-coated to reduce stomach irritation, it still carries a risk of gastrointestinal bleeding, ulcers, and perforation, particularly in individuals with a history of gastrointestinal disorders.
  • Cardiovascular Risks: Long-term use of EC-Naprosyn may increase the risk of heart attack or stroke, especially in patients with pre-existing cardiovascular conditions or those taking it for an extended period.
  • Kidney and Liver Damage: Prolonged use of EC-Naprosyn can impair kidney and liver function, especially in individuals with pre-existing kidney or liver issues.

Interactions with EC-Naprosyn

Common Drug Interactions

  • Anticoagulants: EC-Naprosyn can increase the risk of bleeding when taken with blood thinners like warfarin.
  • Other NSAIDs: Taking EC-Naprosyn with other NSAIDs (e.g., ibuprofen, aspirin) increases the risk of gastrointestinal bleeding and ulcers.
  • Diuretics and ACE inhibitors: Combining EC-Naprosyn with diuretics or ACE inhibitors may reduce the effectiveness of these medications and increase the risk of kidney damage.

Alternatives to EC-Naprosyn

  • Ibuprofen (Advil, Motrin): A commonly used NSAID for pain and inflammation.
  • Celecoxib (Celebrex): A COX-2 selective NSAID with fewer gastrointestinal side effects compared to non-selective NSAIDs.
  • Acetaminophen (Tylenol): An analgesic and antipyretic used for pain relief and fever reduction, with less risk of gastrointestinal side effects.