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Dabigatran Etexilate Mesylate
Dabigatran Etexilate Mesylate is an anticoagulant (blood thinner) used to reduce the risk of stroke and blood clots in patients with non-valvular atrial fibrillation. It is also used to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE). Dabigatran works by inhibiting thrombin, an enzyme involved in blood clot formation. It is commonly prescribed for patients who require long-term anticoagulation therapy, particularly those at higher risk for blood clots or stroke.
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Frequently Asked Questions
How long does it take for Dabigatran to start working?
Dabigatran begins to reduce the risk of blood clotting within a few hours of taking the first dose.
Can I stop taking Dabigatran if I feel fine?
No, do not stop taking Dabigatran without consulting your doctor, even if you feel fine. Stopping suddenly can increase your risk of stroke or blood clots.
What should I do if I miss a dose of Dabigatran?
If you miss a dose, take it as soon as you remember. If it's within 6 hours of the next dose, skip the missed dose and take your next dose at the usual time. Do not double up doses.
Does Dabigatran require regular blood tests like warfarin?
No, Dabigatran does not require routine blood monitoring like warfarin, making it more convenient for long-term use.
Can I take NSAIDs or aspirin with Dabigatran?
Avoid using NSAIDs or aspirin while taking Dabigatran, as they may increase the risk of bleeding. Consult your doctor before taking any new medications.
Comprehensive Drug Guide
How Does Dabigatran Etexilate Mesylate Work?
Dabigatran inhibits thrombin, the enzyme that converts fibrinogen to fibrin during the clotting process. By blocking thrombin, dabigatran prevents the formation of blood clots, thereby reducing the risk of stroke, DVT, and PE.
What is Dabigatran Etexilate Mesylate Used For?
- Reduction of stroke and systemic embolism in patients with non-valvular atrial fibrillation
- Treatment and prevention of deep vein thrombosis (DVT)
- Treatment and prevention of pulmonary embolism (PE)
- Prevention of DVT and PE after hip replacement surgery
Common Dosages
Dabigatran Etexilate Mesylate is available by prescription in capsule form and is not classified as a controlled substance.
- 75 mg and 150 mg strengths
Typical Dosing
FDA Approved Indications
- For non-valvular atrial fibrillation, the typical dose is 150 mg taken twice daily.
- For DVT or PE treatment, 150 mg twice daily after 5 to 10 days of initial treatment with a parenteral anticoagulant.
- Dosing may vary based on kidney function, age, and other individual factors. Always follow your healthcare provider’s instructions.
Off-Label Uses
Who Shouldn't Take Dabigatran Etexilate Mesylate?
Dabigatran Etexilate Mesylate should not be used in individuals with:
- Active bleeding or conditions that increase the risk of bleeding
- Known hypersensitivity to dabigatran or any other components of the drug
- Mechanical heart valves (use in this population is contraindicated)
Advice From The Pharmacist
- Take Dabigatran exactly as prescribed, at the same time each day.
- Do not stop taking this medication without consulting your doctor, as it may increase the risk of stroke or blood clots.
- Store the capsules in the original packaging (do not transfer them to pill organizers), and keep the bottle tightly closed to protect from moisture.
- Swallow the capsule whole with a glass of water. Do not crush, chew, or break the capsule.
- If you miss a dose, take it as soon as you remember, but if it's within 6 hours of the next dose, skip the missed dose. Do not take two doses at once.
Side Effects of Dabigatran Etexilate Mesylate
Common Side Effects
- Indigestion
- Stomach pain
- Nausea
- Minor bleeding (e.g., gums, nosebleeds)
Uncommon/Severe Side Effects
- Unexplained bleeding or bruising
- Blood in urine or stools
- Severe headache or dizziness
- Signs of stroke (e.g., sudden numbness, difficulty speaking)
Risks and Warnings of Dabigatran Etexilate Mesylate
- Bleeding Risk: Dabigatran increases the risk of bleeding, including serious or fatal bleeding. Patients with conditions such as ulcers, kidney disease, or a history of bleeding should use it with caution.
- Discontinuation: Stopping dabigatran suddenly without a replacement anticoagulant may increase the risk of stroke or blood clots. Consult your doctor before stopping this medication.
- Surgery: Inform your healthcare provider or surgeon if you are scheduled for surgery, as dabigatran may need to be stopped several days prior to reduce the risk of excessive bleeding.
Interactions with Dabigatran Etexilate Mesylate
Common Drug Interactions
- NSAIDs (e.g., ibuprofen, aspirin) can increase the risk of bleeding when taken with dabigatran.
- Antiplatelet agents (e.g., clopidogrel) and other anticoagulants may increase bleeding risk when combined with dabigatran.
- P-glycoprotein inhibitors (e.g., ketoconazole, amiodarone) may increase dabigatran levels in the blood.
Alternatives to Dabigatran Etexilate Mesylate
- Warfarin: A traditional anticoagulant that requires regular blood monitoring.
- Rivaroxaban (Xarelto): A direct factor Xa inhibitor used for similar indications.
- Apixaban (Eliquis): Another direct factor Xa inhibitor for stroke prevention and blood clot treatment.
- Edoxaban: A newer anticoagulant with fewer dietary restrictions compared to warfarin.
