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Eliquis
Eliquis is an anticoagulant medication, which means it's designed to prevent the formation of blood clots. It's primarily used in cases of atrial fibrillation (a type of irregular heartbeat) and after hip or knee replacement surgeries. Some possible side effects include minor bleeding, nausea, and minor headaches, but your healthcare provider will weigh these against the benefits of blood clot prevention.
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Frequently Asked Questions
Is Eliquis a blood thinner?
Yep, it sure is. It belongs to a group of drugs called anticoagulants, which work by reducing the body's ability to form clots.
I accidentally missed a dose, what should I do?
If it's close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take more than 1 dose at the same time to make up for missed doses.
Can Eliquis cause bleeding?
Yes, bleeding is one of the major side effects of Eliquis. This can range from minor bleeding like nosebleeds to severe bleeding that requires immediate medical attention.
Can I drink alcohol while I'm taking Eliquis?
While it's not directly contraindicated, it's always a good idea to discuss your alcohol consumption with your healthcare provider. Alcohol can increase the risk of bleeding, particularly in the stomach and intestines, which may be more problematic when taking a blood thinner like Eliquis.
Is it dangerous to stop taking Eliquis suddenly?
Stopping Eliquis can increase your risk of developing a blood clot. Always talk to your healthcare provider before making any changes to how you take your medications.
Comprehensive Drug Guide
How Does Eliquis Work?
Eliquis is a Factor Xa inhibitor that disrupts the blood coagulation cascade, preventing thrombus formation by specifically blocking the enzymatic activity of Factor Xa.
What is Eliquis Used For?
FDA indications: Eliquis is used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It's also used for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE) in patients who have undergone hip or knee replacement surgery.
Off-label uses: It's been used for the treatment of venous thromboembolism and the prevention of recurrent DVT and PE.
Common Dosages
Tablets: 2.5mg, 5mg
Typical Dosing
FDA Approved Indications
- For FDA-approved indications:
- Stroke prevention in nonvalvular atrial fibrillation: 5mg twice daily.
- Prevention of DVT and PE after hip or knee replacement surgery: 2.5mg twice daily beginning 12 to 24 hours post-operation.
Off-Label Uses
- For off-label uses:
- Treatment of DVT and PE: 10mg twice daily for seven days, followed by 5mg twice daily.
- Prevention of recurrent DVT and PE: 2.5mg twice daily after at least six months of anticoagulation therapy.
Who Shouldn't Take Eliquis?
- Have an artificial heart valve.
- Have severe kidney or liver disease.
- Have an increased risk of bleeding due to a bleeding disorder or the use of other medications that increase bleeding risk.
- Are pregnant, planning to become pregnant, or are breastfeeding (consult with a healthcare provider).
- Have had a severe allergic reaction to Eliquis in the past.
Advice From The Pharmacist
- Avoid activities that can increase your risk of bleeding.
- Always take Eliquis with a full glass of water.
- You can take this medication with or without food, whatever is more comfortable for you.
- Do not stop taking Eliquis unless directed by your healthcare provider. If you stop this medication suddenly, it may increase your risk of a blood clot.
- Regular follow-up with your healthcare provider is necessary to monitor your progress.
Side Effects of Eliquis
Common Side Effects
- Common side effects: Minor bleeding, such as nosebleeds or bleeding gums, nausea, and minor headaches.
Uncommon/Severe Side Effects
- Rare side effects: Severe bleeding, signs of liver disease (yellowing of the skin or the whites of the eyes), and symptoms of blood clots (unexpected swelling and pain).
- Severe side effects: If you experience severe bleeding, signs of liver disease, or symptoms of blood clots, seek medical help immediately.
Risks and Warnings of Eliquis
- People with active bleeding from surgery, injury, or other cause should avoid Eliquis.
- Not recommended for those with artificial heart valves, as a serious type of blood clot could occur.
- It should be used under a healthcare provider's supervision if you have a kidney or liver disease.
Interactions with Eliquis
Common Drug Interactions
- Drugs affecting coagulation (like heparin, warfarin, and other anticoagulants)
- Antiplatelet drugs
- Strong inhibitors of both CYP3A4 and P-gp
- Strong inducers of both CYP3A4 and P-gp
Alternatives to Eliquis
- Rivaroxaban
- Dabigatran
- Warfarin
- Edoxaban
- Heparin
