Calcipotriene-Betameth Diprop

Plaque Psoriasis

Ointment/Gel/Foam: Apply a thin layer to the affected areas once daily for up to 4 weeks or as directed by a healthcare provider. Treatment duration may vary depending on the form and severity of the condition.

Calcipotriene-Betamethasone Dipropionate is contraindicated in patients with:

• Known hypersensitivity to calcipotriene, betamethasone, or any other components of the formulation.
• Hypercalcemia (high levels of calcium in the blood) or evidence of vitamin D toxicity.
• Use on the face, groin, or axillae, as these areas are more prone to corticosteroid-induced side effects such as skin thinning.
• Skin infections at the treatment site, as corticosteroids can exacerbate infections.

Patients using Calcipotriene-Betamethasone Dipropionate should be advised to:

• Apply the medication exactly as prescribed and not exceed the recommended amount or duration of use to avoid potential side effects, particularly from the corticosteroid component.
• Avoid prolonged exposure to sunlight or artificial UV light on treated areas, as calcipotriene can increase the skin's sensitivity to UV rays.
• Inform their healthcare provider if they experience any signs of skin irritation, such as burning, stinging, or redness, especially if it persists or worsens.
• Be cautious when using this medication on large areas of the body or for extended periods, as this can increase the risk of systemic absorption of betamethasone, leading to potential side effects such as adrenal suppression.
• Report any signs of hypercalcemia, such as nausea, vomiting, weakness, or confusion, to their healthcare provider immediately.

• Skin irritation at the site of application (such as redness, itching, or dryness)
• Burning or stinging sensation
• Peeling or scaling of the skin
• Mild rash

Serious side effects can include:

• Hypercalcemia: Although rare, overuse of calcipotriene can lead to elevated levels of calcium in the blood. Symptoms include nausea, vomiting, constipation, and confusion.
• Adrenal Suppression: Prolonged use of betamethasone, especially on large body areas, can suppress adrenal gland function, leading to symptoms such as fatigue, weight loss, and low blood pressure.
• Severe Skin Irritation: If irritation is severe or does not improve with continued use, the medication should be discontinued, and the healthcare provider should be consulted.

Hypercalcemia: Patients using large amounts of Calcipotriene-Betamethasone Dipropionate or applying it to large body areas are at risk of developing hypercalcemia. Blood calcium levels should be monitored, especially if high doses or prolonged treatment is required.

Adrenal Suppression: Long-term use or application on large areas of the body can lead to systemic absorption of betamethasone, potentially causing adrenal suppression. This can result in symptoms like fatigue, weight loss, and hypotension.

Skin Atrophy: Prolonged use of topical corticosteroids like betamethasone can lead to thinning of the skin, stretch marks, and increased risk of skin infections.

Calcipotriene-Betamethasone Dipropionate may interact with other medications, including:

• Topical Corticosteroids: Avoid using additional topical corticosteroids on the same treatment areas to prevent additive effects that could increase the risk of side effects.
• Calcium Supplements or Vitamin D Analogs: Concomitant use with other vitamin D products or calcium supplements may increase the risk of hypercalcemia.
• Phototherapy: If undergoing phototherapy for psoriasis, consult with a healthcare provider, as Calcipotriene can increase photosensitivity.

Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.

Alternative treatments for plaque psoriasis include:

• Topical Corticosteroids: Used alone or in combination with other agents to reduce inflammation and itching.
• Topical Retinoids: Such as Tazarotene, which can also normalize skin cell growth.
• Coal Tar Preparations: Which help to slow down the rapid growth of skin cells and reduce scaling.
• Phototherapy: Treatment with ultraviolet light under medical supervision can be effective in reducing psoriasis symptoms.
• Systemic Treatments: Such as methotrexate, cycloSPORINE, or biologic agents for more severe cases.

The choice of treatment depends on the severity of the psoriasis, patient preferences, and the response to previous treatments.